Genotoxic Effects of Airborne Agents

1. Front Matter

   Pages i-xiii

   PDF

2. Assay and Exposure Technology

   1. Session I: Assay and Exposure Technology of In Vitro Microbial Assay Systems Applied to Airborne Agents

      • Joellen Lewtas

      Pages 1-2

   2. An Exposure System for Quantitative Measurements of the Microbial Mutagenicity of Volatile Liquids

      • Eugene D. Barber, William H. Donish

      Pages 3-18

   3. Review of Fractionation and Bioassay Characterization Techniques for the Evaluation of Organics Associated with Ambient Air Particles

      • Larry D. Claxton

      Pages 19-34

   4. Airborne Particle Collection and Extraction Methods Applicable to Genetic Bioassays

      • Robert H. Jungers, Joellen Lewtas

      Pages 35-47

   5. Session II: Assay and Exposure Technology of In Vitro Mammalian Cell Systems Applied to Airborne Agents

      • Donald E. Rounds

      Pages 49-49

   6. In Vitro Analysis of Mammalian Cells Exposed In Vitro and In Vivo to Airborne Agents

      • R. R. Guerrero, D. E. Rounds

      Pages 51-73

   7. Methods for Detecting Gaseous and Volatile Carcinogens Using Cell Transformation Assays

      • G. G. Hatch, P. D. Mamay, M. L. Ayer, B. C. Casto, S. Nesnow

      Pages 75-90

   8. CHO/HGPRT Mutation Assay: Evaluation of Gases and Volatile Liquids

      • David F. Krahn, Frances C. Barsky, Kevin T. McCooey

      Pages 91-103

   9. Lung Cells Grown on Cellulose Membrane Filters as an In Vitro Model of the Respiratory Epithelium

      • Ronald E. Rasmussen, T. Timothy Crocker

      Pages 105-120

   10. Session III. Plant Bioassays for the Detection of Airborne Genotoxic Agents

       • L. A. Schairer

       Pages 121-122

   11. Monitoring Ambient Air for Mutagenicity Using the Higher Plant Tradescantia

       • L. A. Schairer, R. C. Sautkulis, N. R. Tempel

       Pages 123-140

   12. Environmental Clastogens Detected by Meiotic Pollen Mother Cells of Tradescantia

       • Te-Hsiu Ma, Van A. Anderson, Iftikharuddin Ahmed

       Pages 141-157

   13. Plant Genetic Systems with Potential for the Detection of Atmospheric Mutagens

       • Milton J. Constantin

       Pages 159-177

   14. Session IV: Animal Exposure Technology for the Detection of Genotoxic Agents

       • Robert T. Drew

       Pages 179-179

   15. Systems for Exposure of Animals to Airborne Agents

       • Robert T. Drew

       Pages 181-195

   16. Techniques for the Generation and Monitoring of Vapors

       • Gary O. Nelson

       Pages 197-207

   17. Problems Associated with Assessing the Mutagenicity of Inhalable Particulate Matter

       • Otto G. Raabe

       Pages 209-223

3. Airborne Agents

   1. An Overview of the Problem of Benzene Toxicity and Some Recent Data on the Relationship of Benzene Metabolism to Benzene Toxicity

      • Robert Snyder, David Sammett, Charlotte Witmer, James J. Kocsis

      Pages 225-240

   2. Benzene Metabolites: Evidence for an Epigenetic Mechanism of Toxicity

      • R. D. Irons, R. W. Pfeifer

      Pages 241-256

For at least 40 years there has been a great interest in the problems created by infectious airborne agents and other toxic sub­ stances transported through the air. During the Second World War, this problem grew out of the very high incidence of upper respira­ tory infections appearing in new military recruits who were brought together in very large, open quarters. As a result, very interest­ ing methods were developed to measure these airborne agents, espe­ cially bacteria, and some important methods were refined for their control. These methods primarily concentrated on ultraviolet radia­ tion, propylene glycol and other means to reduce the dust in an en­ vironment. Because of the specialized circumstances at that time the whole consideration of airborne particles became prominent. Now, with the new strides in the recognition of mutagenic and carcinogenic effects attributed to exposure to airborne chemicals from today's technology, the problem has again become quite promi­ nent. The development of experimental chambers has made it possible to conduct studies under carefully controlled conditions.

• Potential
• cancer
• experiment
• metabolism
• microorganism
• mutagenesis
• research
• toxicity

• Brookhaven National Laboratory, Upton, USA

  Raymund R. Tice, Daniel L. Costa, Karen M. Schaich

Policies and ethics