Newcastle Disease

1. Front Matter

   Pages i-xiii

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2. Historical Aspects

   • D. J. Alexander

   Pages 1-10

3. Newcastle Disease Virus — an Avian Paramyxovirus

   • D. J. Alexander

   Pages 11-22

4. Virus Structure

   • A. C. R. Samson

   Pages 23-44

5. Newcastle Disease Virus Replication

   • Mark E. Peeples

   Pages 45-78

6. Molecular Cloning and Nucleotide Sequencing of Newcastle Disease Virus

   • Neil S. Millar, Peter T. Emmerson

   Pages 79-97

7. Molecular Basis of Infectivity and Pathogenicity of Newcastle Disease Virus

   • Rudolf Rott, Hans-Dieter Klenk

   Pages 98-112

8. Heterogeneity within Strains of Newcastle Disease Virus: Key to Survival

   • Robert P. Hanson

   Pages 113-130

9. Monoclonal Antibodies in Research, Diagnosis and Epizootiology of Newcastle Disease

   • P. H. Russell

   Pages 131-146

10. Newcastle Disease Diagnosis

    • D. J. Alexander

    Pages 147-160

11. Newcastle Disease

    • J. B. McFerran, R. M. McCracken

    Pages 161-183

12. Panzootic Newcastle Disease Virus in Pigeons

    • H. Vindevogel, J. P. Duchatel

    Pages 184-196

13. Newcastle Disease in Free-Living and Pet Birds

    • Erhard F. Kaleta, Christine Baldauf

    Pages 197-246

14. Geographical Distribution

    • P. B. Spradbrow

    Pages 247-255

15. Newcastle Disease : Methods of Spread

    • D. J. Alexander

    Pages 256-272

16. Newcastle Disease in Tropical and Developing Countries

    • D. A. Higgins, K. F. Shortridge

    Pages 273-302

17. Newcastle Disease : Control Policies

    • G. Bennejean

    Pages 303-317

18. Control by Vaccination

    • G. Meulemans

    Pages 318-332

19. Newcastle Disease — Vaccine Production

    • Garry M. Cross

    Pages 333-346

20. Quality Control of Vaccines

    • Denise H. Thornton

    Pages 347-365

Most of the chapters of this book were written during 1987 which was the Diamond Jubilee year of the publication of the first reports of Newcastle disease in 1927. During the intervening years the nature of the Poultry Industry throughout the World has changed, or is in the process of changing, dramatically from one based on small village or farm flocks, frequently kept as a sideline, to an industry based on large flocks, sometimes consisting of hundreds of thousands of birds, run by multinational companies. To all these flocks, both large and small, Newcastle disease poses a considerable threat to their well-being and profitability and it is not unreasonable to state that hardly a single commercial flock of poultry is raised in the world without Newcastle disease having some effect due to actual disease, prophylactic vaccination or restrictions placed on rearing, movement, processing, sale or export of birds and products. In addition, recent years have produced developments in virology and associated biological technology which would have been unbelievable when Newcastle disease virus was first isolated. The economic importance of Newcastle disease virus and its use as a laboratory model has meant that major advances have been quickly applied to the field situation whenever possible and, as a result, a much fuller understanding, not only of the biochemistry and basic virology of the virus but also the ecology, epizootiology, antigenicity, immunology and other important aspects in the control of the disease has been achieved.

• antibody
• antigen
• diagnosis
• ecology
• immunology
• vaccination
• vaccine
• virology
• virus

`The book is a must for all those interested in Newcastle disease, be it in the diagnosis and control of an economically important disease of poultry or as a useful laboratory model and Dr. Alexander and his contributors are to be congratualted.'
J.K.A. Cook, The Veterinary Record, April 1989.

• Central Veterinary Laboratory, New Haw, Weybridge, Surrey, UK

  D. J. Alexander

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