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Airway Smooth Muscle in Health and Disease

  • Book
  • © 1989

Overview

Editors:
  1. Ronald F. Coburn

    1. Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, USA

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Table of contents (15 chapters)

  1. Front Matter

    Pages i-xvi
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  2. Structure of Airway Smooth Muscle and Its Innervation

    • Giorgio Gabella
    Pages 1-16

  3. Integration of Neural Inputs in Peripheral Airway Ganglia

    • Ronald F. Coburn
    Pages 17-34

  4. Nervous Receptors in the Tracheobronchial Tree

    • John G. Widdicombe
    Pages 35-53

  5. Polypeptide-Containing Neurons and Their Function in Airway Smooth Muscle

    • Sami I. Said
    Pages 55-76

  6. Cell-Surface Receptors in Airway Smooth Muscle

    • Peter J. Barnes
    Pages 77-97

  7. Cellular Control Mechanisms in Airway Smooth Muscle

    • Primal de Lanerolle
    Pages 99-125

  8. Transduction and Signaling in Airway Smooth Muscle

    • Carl B. Baron
    Pages 127-149

  9. Electrical Properties of Airway Smooth Muscle

    • Tadao Tomita
    Pages 151-167

  10. Ion Channels in Airway Smooth Muscle

    • Michael I. Kotlikoff
    Pages 169-182

  11. Coupling Mechanisms in Airway Smooth Muscle

    • Ronald F. Coburn, Kenji Baba
    Pages 183-197

  12. Postulated Mechanisms Underlying Airway Hyperreactivity

    • Douglas W. P. Hay
    Pages 199-235

  13. Airway Epithelial Metabolism and Airway Smooth Muscle Hyperresponsiveness

    • David B. Jacoby, Jay A. Nadel
    Pages 237-266

  14. Airway Hyperreactivity

    • James C. Hogg
    Pages 267-276

  15. Current Concepts of the Pathophysiology of Allergic Asthma

    • Ruth Jacobs, Michael Kaliner
    Pages 277-299

  16. Exercise-Induced Bronchoconstriction

    • Joseph F. Souhrada
    Pages 301-313

  17. Back Matter

    Pages 315-318
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Keywords

About this book

I organized this book because there is a need to put together in book form recent advances in our knowledge of how airway smooth muscle:works in health and in disease. After a period when it seemed that progress was very slow, there has been in the past few years an incredibly rapid gathering of knowledge in this area. In particular, our understanding has improved regarding the cascades of events that follow the initial binding of agonist to plasma membrane receptors and that lead to the cross-bridge movements that determine contraction. This advance in our knowledge was stimulated by use of single-and whole-cell channel recordings of plasma membrane currents and by description of the l3-receptor-GTP-binding protein-adenylate cyclase-cAMP coupling system, which serves as a model for other coupling mechanisms. The discovery of the receptor-activated inositol phospholipid transduction system has greatly stimulated research and led to advances in our understanding of mechanisms involved in smooth muscle con­ traction. Major advances were also triggered by the development of indicators for measuring free cytosolic calcium concentration and starting the unraveling of 2 the events involved in Ca + -dependent activation of contractile proteins. Al­ though most of the studies that led to our current understanding of these areas were performed on nonairway smooth muscle, these studies usually add to our understanding of airway smooth muscle, and there is an enlarging body of data that have been obtained on airway smooth muscle.

Editors and Affiliations

  • Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, USA

    Ronald F. Coburn

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