Ivermectin and Abamectin

1. Front Matter

   Pages i-xx

   PDF

2. Part I

   1. Chemistry

      • M. H. Fisher, H. Mrozik

      Pages 1-23

   2. Isolation and Characterization of the Producing Organism

      • R. W. Burg, E. O. Stapley

      Pages 24-32

   3. Fermentation Development and Process Improvement

      • Mary Nallin Omstead, Louis Kaplan, Barry C. Buckland

      Pages 33-54

   4. Biosynthesis

      • S. T. Chen, O. D. Hensens, M. D. Schulman

      Pages 55-72

   5. Mode of Action of Ivermectin

      • M. J. Turner, J. M. Schaeffer

      Pages 73-88

3. Part II

   1. Toxicology

      • George R. Lankas, Lea R. Gordon

      Pages 89-112

   2. Pharmacokinetics of Ivermectin in Animals and Humans

      • David W. Fink, Arturo G. Porras

      Pages 113-130

   3. Metabolism and Tissue Residues

      • Shuet-Hing Lee Chiu, Anthony Y. H. Lu

      Pages 131-143

   4. Chemical Assay for Ivermectin in Edible Tissues

      • George V. Downing

      Pages 144-148

   5. Safety of Ivermectin in Target Animals

      • J. D. Pulliam, J. M. Preston

      Pages 149-161

   6. Environmental Aspects of Ivermectin Usage in Livestock: General Considerations

      • B. A. Halley, R. J. Nessel, A. Y. H. Lu

      Pages 162-172

   7. Environmental Aspects of Use of Ivermectin and Abamectin in Livestock: Effects on Cattle Dung Fauna

      • R. A. Roncalli

      Pages 173-181

   8. Environmental Aspects of Abamectin Use in Crop Protection

      • P. G. Wislocki, L. S. Grosso, R. A. Dybas

      Pages 182-200

   9. Worker Safety Aspects of Abamectin Use in Crop Protection

      • L. S. Grosso, R. A. Dybas, S. F. Rickard

      Pages 201-214

4. Part III

   1. Use of Ivermectin in Cattle, Sheep, Goats, and Swine

      • G. W. Benz, R. A. Roncalli, S. J. Gross

      Pages 215-229

   2. Use of Abamectin in Cattle

      • G. W. Benz, J. L. Cox

      Pages 230-233

   3. Use of Ivermectin in Horses

      • William C. Campbell, W. H. D. Leaning, R. L. Seward

      Pages 234-244

   4. Use of Ivermectin in Dogs and Cats

      • William C. Campbell

      Pages 245-259

   5. Use of Ivermectin in Laboratory and Exotic Mammals and in Birds, Fish, and Reptiles

      • M. D. Soll

      Pages 260-286

Ivermectin and abamectin, members of the avermectin family of compounds, were introduced to the market in the 1980's as a veterinary antiparasitic drug and agricultural pesticide, respectively. Their acceptance and commercial success have been remarkable; both are highly effective and in worldwide use. The efficacy of ivermectin in river blindness has expanded the interest in its use in human medicine. In response to the intense scientific and industrial interest in ivermectin and abamectin and the likelihood that they will be forerunners of an expanding family of drugs, this comprehensive monograph satisfies the need for a review and synthesis of current knowledge about the use of these substances in crop protection as well as in cattle, sheep, swine, horses, dogs, cats, birds, fish, reptiles, and in man. This overview presents chemical, biochemical, and microbiological data, as well as pharmacological, safety, and environmental aspects and covers practical use of the compounds as antiparasitic and pesticide agents, as well as the available safety data that have emerged from the clinical experience with human applications.

• chemistry
• crop protection
• development
• drug
• fish
• kinetics
• medicine
• metabolism
• parasite
• pesticide
• pharmacokinetics
• reptiles
• toxicology

• Merck Institute for Therapeutic Research, Rahway, USA

  William C. Campbell

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