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Pathobiology of the Human Atherosclerotic Plaque

  • Conference proceedings
  • © 1990

Overview

Editors:
  1. Seymour Glagov

    1. The University of Chicago Hospital, Chicago, USA

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  2. William P. Newman

    1. Department of Pathology, Louisiana State University, New Orleans, USA

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  3. Sheldon A. Schaffer

    1. Colestech Corporation, Hayward, USA

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Table of contents (63 papers)

  1. Front Matter

    Pages i-xxxi
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  2. Introduction

    1. Front Matter

      Pages xxxi-xxxi
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    2. Questions About the Natural History of Human Atherosclerosis

      • Henry C. McGill Jr
      Pages 1-11

  3. Cellular Contents

    1. Front Matter

      Pages 1-1
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    2. Arterial Endothelial Structure and Permeability as It Relates to Susceptibility to Atherogenesis

      • Ross G. Gerrity
      Pages 13-45

    3. Second Messengers in Human Vascular Endothelial Cells: Regulation of Endothelial Monolayer Formation and Repair

      • Vladimir N. Smirnov, Alexander S. Antonov, Matvey E. Lukashev, Yuri A. Romanov, J. Frederic Cornhill, Ross G. Gerrity
      Pages 47-62

    4. Cytoskeletal Characterization of Smooth Muscle Cells of Human and Experimental Atherosclerotic Plaques

      • G. Gabbiani
      Pages 63-68

    5. Phenotypic Changes in Smooth Muscle Cells of Human Atherosclerotic Plaques

      • G. R. Campbell, J. H. Campbell, A. H. Ang, I. L. Campbell, S. Horrigan, J. A. Manderson et al.
      Pages 69-92

    6. Changes in the Cells of Atherosclerotic Lesions as Advanced Lesions Evolve in Coronary Arteries of Children and Young Adults

      • H. C. Stary
      Pages 93-106

    7. Inflammatory Components of the Human Atherosclerotic Plaque

      • Colin J. Schwartz, Eugene A. Sprague, Anthony J. Valente, Jim L. Kelley, Ellen H. Edwards, C. Alan Suenram
      Pages 107-120

    8. The Role of Macrophages in Human Atherosclerosis

      • Malcolm J. Mitchinson, Keri L. H. Carpenter, Richard Y. Ball
      Pages 121-128

    9. Recent Observations on Human Atherosclerotic Lesions, and their Possible Significance

      • M. Daria Haust
      Pages 129-144

  4. Tissue Organization and Architecture

    1. Front Matter

      Pages 3-3
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    2. Intimal Lipids and Associated Changes in Intimal Composition

      • Elspeth B. Smith
      Pages 145-153

    3. Evolution of the Atherosclerotic Plaque—A Physico—chemical Approach to Lipid Deposition

      • Donald M. Small
      Pages 155-166

    4. Modification of Collagen and Elastin in the Human Atherosclerotic Plaque

      • William D. Wagner
      Pages 167-188

    5. Nature and Importance of Proteoglycans in the Atherosclerotic Plaque

      • G. S. Berenson, B. Radhakrishnamurthy, S. R. Sinivasan, P. Vijayagopal, E. R. Dalferes Jr.
      Pages 189-208

    6. Biochemical and Immunological Evidence for the Presence of Lipoprotein-Antilipoprotein Immune Complexes in Human Atherosclerotic Plaques

      • William Hollander, Antonio Lazzari, Carl Franzblau
      Pages 209-234

    7. Mechanisms of Calcification in Atherosclerosis

      • H. C. Anderson, D. H. McGregor, A. Tanimura
      Pages 235-249

    8. Characterization of Nucleating Proteolipids from Calcified and Non-Calcified Atherosclerotic Lesions

      • Rosemarie Romeo, Joan M. Augustyn, Gretchen Mandel, Assaad S. Daoud
      Pages 251-262
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Keywords

About this book

Seymour Glagov The last meeting, devoted exclusively to an examination of the atherosclerotic plaque, took place in Chicago 25 years ago under the joint auspices of the Council on Arteriosclerosis of the American Heart Association and the Chicago Heart Association. The proceedings were published subsequently in a volume entitled "Evolution of the Atherosclerotic Plaque", edited by Richard J. Jones (1). Both experimental and human lesions were considered and several provocative new approaches to the disorder were discussed. The electron microscope was being applied systematically to the study of blood vessels at that time, so that details of the infrastructure and cellular composition of the artery wall and of atherosclerotic lesions were presented in some detail. There was, as one result of these explorations, considerable discussion of morphologic evidence suggesting that the principal cell involved in the atherogenic process was neither the fibroblast nor the macrophage, as had been supposed, but the smooth muscle cell. In particular, the findings indicated that this cell could incorporate lipid and become a foam cell.

Editors and Affiliations

  • The University of Chicago Hospital, Chicago, USA

    Seymour Glagov

  • Department of Pathology, Louisiana State University, New Orleans, USA

    William P. Newman

  • Colestech Corporation, Hayward, USA

    Sheldon A. Schaffer

Bibliographic Information

  • Book Title: Pathobiology of the Human Atherosclerotic Plaque

  • Editors: Seymour Glagov, William P. Newman, Sheldon A. Schaffer

  • DOI: https://doi.org/10.1007/978-1-4612-3326-8

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag New York Inc. 1990

  • Softcover ISBN: 978-1-4612-7968-6Published: 30 September 2011

  • eBook ISBN: 978-1-4612-3326-8Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XXXI, 923

  • Topics: Cardiology, Pathology

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