Overview
- Editors:
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Clarence J. Gibbs
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Laboratory of Central Nervous System Studies Basic Neurosciences Program Division of Intramural Research, National Institute of Neurological Disorders and Stroke National Institutes of Health, Bethesda, USA
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Table of contents (29 chapters)
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The Potential Risk to Humans of Amyloids in Animals
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Host Range and Pathogenesis
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- Gerald A. H. Wells, Michael Dawson, Stephen A. C. Hawkins, Anthony R. Austin, Robert B. Green, Ian Dexter et al.
Pages 28-44
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Transmission and Pathogenesis of Spongiform Encephalopathies
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- James L. Hourrigan, Albert L. Klingsporn
Pages 59-83
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- Clarence J. Gibbs Jr., Jiri Safar, Michael P. Sulima, Alfred E. Bacote, R. Andres San Martin
Pages 84-91
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- Randall C. Cutlip, Janice M. Miller, Richard E. Race, Allen L. Jenny, Howard D. Lehmkuhl, Mark M. Robinson
Pages 92-96
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- A. A. Schudel, B. J. Carrillo, E. L. Weber, J. Blanco Viera, E. J. Gimeno, C. Van Gelderen et al.
Pages 138-154
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Biochemistry: Protein Chemistry, Molecular Biology, and Molecular Genetics of the Spongiform Encephalopathies
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Front Matter
Pages 177-177
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- Glenn C. Telling, Michael Scott, Stanley B. Prusiner
Pages 202-231
About this book
The very first international working discussion on slow infections of the nervous system was entitled "Slow, Latent, and Temperate Virus Infec tions" and was held at the National Institutes of Health (NIH) in December 1964. The primary impetus was the discovery and investigation of kuru in New Guinea by D. Carleton Gajdusek, M. D. This working discussion brought together investigators in human and veterinary medicine, virolo gists, microbiologists, and neuropathologists actively engaged in laboratory work with viruses that illustrated properties of latency, masking, slowness, or temperateness, with emphasis on subacute and chronic neurologic dis eases of unknown etiology. In the Preface to the monograph of published papers presented at the working discussion, Gajdusek and Gibbs wrote the following: After microbiology had given solution to the etiology of most acute infections of the central nervous system and after fungi and bacteria had been incriminated in impor tant chronic disorders of the nervous system such as torula and tuberculosis men ingitis, we have been left, in neurology, with a wide range of subacute and chronic affections of the central nervous systems of unknown etiology. Some of these diseases, still listed as idiopathic, are among the most prevalent afflictions of the central nervous system. Many others with familial patterns of occurrence do not yet have their basic pathogenesis or underlying metabolic defect elucidated, although we tend to think of them as genetically mediated.
Editors and Affiliations
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Laboratory of Central Nervous System Studies Basic Neurosciences Program Division of Intramural Research, National Institute of Neurological Disorders and Stroke National Institutes of Health, Bethesda, USA
Clarence J. Gibbs
