Overview
- Editors:
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Thomas R. Ziegler
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Department of Medicine, Emory University School of Medicine, Atlanta, USA
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Glenn F. Pierce
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Department of Preclinical Development, PRIZM Pharmaceuticals, San Diego, USA
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David N. Herndon
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Shriners Burns Institute, The University of Texas Medical Branch, Galveston, USA
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Table of contents (20 chapters)
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Front Matter
Pages i-xviii
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General Concepts
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- Stephanie Rohovsky, Patricia A. D’Amore
Pages 8-26
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- John F. Hansbrough, Hans Oliver Rennekampff
Pages 37-55
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- Arvind Y. Krishna, Lawrence S. Phillips
Pages 56-76
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Role of Nutrients in Wound Healing Responses
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- Michael R. Schäffer, Adrian Barbul
Pages 79-91
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- Anders E. Ulland, Michael D. Caldwell
Pages 92-103
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- Thomas R. Ziegler, Alan B. Puckett, Daniel P. Griffith, John L. Galloway
Pages 104-147
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Endogenous Growth Factors and Wound Healing
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Front Matter
Pages 149-149
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- David M. Ornitz, Gabriel Waksman
Pages 151-174
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- Wes J. Arlein, Michael D. Caldwell
Pages 186-205
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- Roy W. Tarnuzzer, Shawn P. Macauley, Bruce A. Mast, Jane S. Gibson, Michael C. Stacey, Naomi Trengrove et al.
Pages 206-228
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Clinical Application of Growth Hormone and IGF-I Therapy
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Front Matter
Pages 229-229
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- David N. Herndon, Edgar J. Pierre, J. Keith Rose, Karina N. Stokes, Robert E. Barrow
Pages 231-244
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- Rafael Vara-Thorbeck, Estrella Ruiz-Requena, José Antonio Guerrero
Pages 245-259
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About this book
The biology of wound healing and tissue repair are increasingly being defined. At the same time, the availability of recombinant peptide growth factors for clinical investigation has prompted numerous trials of growth factor administration as adjunctive therapy to enhance the rate and quality of acute and chronic wound repair. New basic science information on growth factor function and regulation obtained in the research laboratory is actively being applied in animal studies and in clinical research settings. In addition to studies of surface wounds, an increasing number of investiga tions on growth factor administration have focused on healing and repair in nondermal tissues such as the intestinal tract and other organs. While the amount of new information on the molecular biology of growth factor expression, signaling, and function has been exponential in recent years, results of many clinical trials on growth factor administration in wound healing have been disappointing. This maybe due, in part, to the heterogeneity of clinical wounds and the patients who harbor them, less than adequate standardization of care in experimental and control groups, issues related to drug dosing, and inadequate control for important issues relevant to healing such as nutrient intake and underlying nutritional status.
Editors and Affiliations
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Department of Medicine, Emory University School of Medicine, Atlanta, USA
Thomas R. Ziegler
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Department of Preclinical Development, PRIZM Pharmaceuticals, San Diego, USA
Glenn F. Pierce
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Shriners Burns Institute, The University of Texas Medical Branch, Galveston, USA
David N. Herndon
