Cardiac Markers

1. Front Matter

   Pages i-ix

   PDF

2. Clinical Aspects

   1. Front Matter

      Pages 1-1

      PDF

   2. Introduction to Coronary Artery Disease (CAD) and Biochemical Markers

      • Alan H. B. Wu

      Pages 3-20

   3. Pathophysiology of Acute Coronary Syndromes

      • Satyendra Giri, David D. Waters, Alan H. B. Wu

      Pages 21-44

   4. Pathophysiology and Treatment of Acute Myocardial Ischemia and Infarction

      • Gary B. Green, Edward S. Bessman, Sol F. Green

      Pages 45-74

   5. Markers of Myocardial Injury in the Evaluation of the Emergency Department Patient with Chest Pain

      • Gary B. Green, Sol F. Green

      Pages 75-89

   6. Ultrastructure of the Striated Muscle Cell

      • Robert G. McCord, Allen W. Clark

      Pages 91-100

3. Cytoplasmic Markers

   1. Front Matter

      Pages 101-101

      PDF

   2. Myoglobin and Carbonic Anhydrase III

      • Hemant C. Vaidya, H. Kalervo Vaananen

      Pages 103-112

   3. Creatine Kinase, Isoenzymes, and Variants

      • Alan H. B. Wu

      Pages 113-125

   4. CK-MB Activity Assays

      • Alan H. B. Wu

      Pages 127-142

   5. CK-MB Measurements by Immunoassay

      • Sol F. Green

      Pages 143-157

   6. CK Isoforms

      • Sol F. Green

      Pages 159-170

   7. Lactate Dehydrogenase and its Isoenzymes

      • Shan S. Wong

      Pages 171-190

4. Structural Markers

   1. Front Matter

      Pages 191-191

      PDF

   2. Biochemistry and Molecular Biology of Troponins I and T

      • Kenneth J. Dean

      Pages 193-204

   3. Cardiac Troponin T as a Marker of Myocardial Injury

      • Kenneth J. Dean

      Pages 205-227

   4. Cardiac Troponin I

      • Fred S. Apple

      Pages 229-243

   5. Myosin Light and Heavy Chains

      • Mauro Panteghini

      Pages 245-256

5. Future Assay and Format

   1. Front Matter

      Pages 257-257

      PDF

Cardiac Markers is a comprehensive, up-to-date summary of clinical information on serum cardiac markers for coronary artery disease. This book reviews in detail the biochemistry, clinical significance, and analytical measurements for each marker, as well as the advantages and limitations of existing and proposed markers. Comprehensive descriptions of therapeutic approaches to manage patients are presented. Also included are up-to-date listings of primary references and commercial methodologies, the latest data on the pathophysiology of unstable angina, and a discussion of the new emergency-room chest pain centers. Anyone who needs to know how to examine, diagnose, treat, and manage patients with acute chest pain and heart attacks will find this book indispensable.

• biochemistry
• biology
• cell
• coronary artery disease
• heart
• molecular biology
• pathophysiology
• physiology

"...addresses the need in a variety of disciplines for an understanding of the evolving role of cardiac markers, particularly in relation to the diagnosis and treatment of acute coronary syndromes. The book provides a concise and informative summary of a rapidly developing field and will be a useful addition to the book-shelves of clinical pathologists, emergency physicians, and cardiologists." -New England Journal of Medicine

"...a valuable addition to the compendium of laboratory medicine literature on diagnostic tests and their appropriate clinical application...highly recommended for any individual interested in the state-of-the-art of appropriate laboratory assessment of the acute coronary syndrome patient." -Doody's Health Sciences Book Review Journal

"This comprehensive book not only offers physicians a complete guide to the use of cardiac markers in clinical practice, but also provides clinical laboratories with detailed information on the new markers which are now becoming standard." - Clinical Laboratory International

• Hartford Hospital, Hartford, USA

  Alan H. B. Wu

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