GHRH, GH, and IGF-I

1. Front Matter

   Pages i-xix

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2. Overview of Physiology of the GHRH-Somatostatin-GH-IGF-I Axis

   1. Front Matter

      Pages 1-1

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   2. Physiology of the Growth Hormone Releasing Hormone-Somatostatin-Growth Hormone-Insulin-Like Growth Factor I Axis

      • Lawrence A. Frohman

      Pages 3-10

   3. Role of Somatostatin in the Regulation of Growth Hormone Secretion

      • Seymour Reichlin

      Pages 11-18

   4. Growth Hormone Releasing Hormone and Growth Hormone Releasing Peptides

      • Mary Lee Vance, Joseph A. Aloi, Mark L. Hartman, Susan E. Kirk, Michael O. Thorner

      Pages 19-24

   5. GH Binding Protein, GH Receptors, and Domains Involved in Signal Transduction

      • P. A. Kelly, J. Finidori, M.-C. Postel-Vinay, M. Edery, L. Goujon, A. Sotiropoulos et al.

      Pages 25-37

   6. Insulin-Like Growth Factors During Development

      • Derek LeRoith, Stefan Neuenschwander, Antolii Koval, Charyse Sindler, Charles T. Roberts Jr.

      Pages 38-48

3. Effects of Recombinant Human GH and/or IGF-I in Catabolic Illness

   1. Front Matter

      Pages 49-49

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   2. Anabolic Effects of Recombinant Human Growth Hormone and Insulin-Like Growth Factor I in Human Disease

      • Raymond L. Hintz

      Pages 51-55

   3. Growth Hormone in Children with Chronic Renal Disease: Some Metabolic Considerations

      • D. F. Geary, K. Welch

      Pages 56-60

   4. Growth Hormone: The Visible Difference in Burn Care

      • Michael J. Muller, Thomas C. Rutan, David N. Herndon

      Pages 61-74

   5. Effects of Recombinant Human Growth Hormone on Body Composition and Metabolism in HIV-Associated Wasting

      • K. Mulligan, C. Grunfeld, M. K. Hellerstein, R. A. Neese, M. Schambelan

      Pages 75-90

   6. Administration of Growth Hormone as an Adjunct to Nutritional Support in Critical Illness

      • Thomas R. Ziegler

      Pages 91-109

   7. Strategies for the Use of Recombinant Human Growth Hormone and Insulin-Like Growth Factor I in Amyotrophic Lateral Sclerosis

      • Barry W. Festoff, Shi X. Yang, David Stong

      Pages 110-128

4. Contemporary Issues in Growth and Development

   1. Front Matter

      Pages 129-129

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   2. Contemporary Issues in Growth and Development: An Overview

      • George A. Werther

      Pages 131-135

   3. Use of Recombinant IGF-I in Syndromes of GH Insensitivity

      • Ron G. Rosenfeld, Arlan L. Rosenbloom, Jaime Guevara-Aguirre

      Pages 136-142

   4. Use of Growth Hormone in Non-Growth-Hormone-Deficient Children: Physiologic, Pharmacologic, and Ethical Issues

      • Barry B. Bercu, Howard J. Heinze, Richard F. Walker

      Pages 143-168

   5. Growth Hormone Treatment of Nonelderly Adults with GH Deficiency

      • Jens S. Christiansen, Jens O. L. Jørgensen, Nina Vahl, Anders Juul, Jørn Müller, Niels E. Skakkebæk

      Pages 169-175

5. Effects of rhGH and IGF-I on Intermediary and Bone Metabolism

   1. Front Matter

      Pages 177-177

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Recent research suggests that adult growth hormone (GH) deficiency, whether of pathological or physiological origin, is associated with a dis­ tinct syndrome that includes alterations in body composition, endocrine­ metabolic function, immune competence, and physical and psychosocial well-being. Not surprisingly, substantial investigative effort is currently focused on validating the above hypothesis and on determining whether restoration of a normal GH-IGF-I axis in various states of adult GH deficiency is clinically useful, safe, and cost-beneficial. This book contains the proceedings from the Symposium on GHRH, GH, and IGF-I: Basic and Clinical Advances, held December 9 to 12, 1993, in San Diego, California, and sponsored by Serono Symposia USA, Inc. The conference was meant to highlight selected novel and exciting clinical research developments related to possible therapeutic uses of recombinant human GH and IGF-I, GHRH, GH releasing peptides, and related GH secretagogues. This meeting occurred only one year after a similar Serono symposium that was somewhat more oriented to novel basic science discoveries, thus attesting to the current scientific and clinical interest in this area.

• Amino acid
• Diabetes
• Diabetes mellitus
• Lipid
• bone
• growth factor
• insulin-like
• metabolism
• physiology
• signal transduction

• Division of Endocrinology and Metabolism Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, USA

  Marc R. Blackman

• Division of Geriatric Medicine and Gerontology Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, USA

  Jesse Roth, Jay R. Shapiro

• Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, USA

  S. Mitchell Harman

Policies and ethics