Calcium and Contractility

1. Front Matter

   Pages i-xx

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2. Structure of Smooth Muscle

   • R. E. Garfield, A. P. Somlyo

   Pages 1-36

3. Calcium Antagonists and Ionophores

   • D. J. Triggle, R. A. Janis

   Pages 37-60

4. Calcium Compartments and Mobilization During Contraction of Smooth Muscle

   • Rodger Loutzenhiser, Paul Leyten, Kooichi Saida, Cornelis van Breemen

   Pages 61-92

5. Mechanisms of Smooth Muscle Relaxation

   • T. Godfraind, R. C. Miller

   Pages 93-117

6. Smooth Muscle Relaxants

   • Charles V. Jackson, John H. McNeill

   Pages 119-141

7. Cell-to-Cell Communication in Smooth Muscle

   • R. E. Garfield

   Pages 143-173

8. Calcium Regulation of Smooth Muscle Actomyosin

   • Samuel Chacko, Arline Rosenfeld, George Thomas

   Pages 175-190

9. Studies on Skinned Fiber Preparations

   • Kaushik D. Meisheri, J. Casper Rüegg, Richard J. Paul

   Pages 191-224

10. Smooth Muscle Subcellular Fractionation

    • A. M. Kidwai

    Pages 225-244

11. Calcium-Handling Studies Using Isolated Smooth Muscle Membranes

    • A. K. Grover

    Pages 245-269

12. Receptor Binding Studies on Smooth Muscle Subcellular Fractions

    • D. J. Crankshaw

    Pages 271-298

13. Calcium-Handling Defects and Smooth Muscle Pathophysiology

    • C. Y. Kwan

    Pages 299-325

14. Adrenergic Interactions in Smooth Muscle Contractility

    • C. R. Triggle

    Pages 327-350

15. Cholinergic Interactions and Vascular Smooth Muscle Tone

    • Tony J-F. Lee

    Pages 351-383

16. Nonadrenergic, Noncholinergic (NANC) Neuronal Inhibitory Interactions with Smooth Muscle

    • E. E. Daniel

    Pages 385-426

17. Nonadrenergic, Noncholinergic (NANC) Neuronal Excitatory Interactions with Smooth Muscle

    • E. E. Daniel

    Pages 427-455

18. Peptide Calcium Interactions in Smooth Muscle

    • J. E. T. Fox

    Pages 457-477

19. Back Matter

    Pages 479-487

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In organizing the present volume, we had two intentions. The first was to present the best current understanding of the mechanisms of calcium mobilization during excitation­ contraction coupling of smooth muscle at a level suited to the needs of professionals interested in smooth muscle pharmacology and pathophysiology, while remaining appreciable by graduate and medical students. The second intention was to provide in­ sight into present-day controversies, as well as the latest ad­ vances achieved by researchers in this field. Thus, we have thor­ oughly discussed both the techniques and the concepts derived from their application. An attempt has also been made here to answer a number of profoundly important questions: What are the mechanisms and agents responsible for the control of contractility? What are the accompanying changes in the state of intracellular calcium ions and the mechanisms responsible for them? How does the regula­ tion of contractility occur directly at the level of the actomyosin activity? What role do gap junctions play in cell-to-cell coupling? What are the roles of cholinergic, adrenergic, peptidergic, and nonadrenergic noncholinergic interactions in calcium mobiliza­ tion in smooth muscle? What changes occur in hypertension? The impact of these recent techniques on future research is also reflected upon.

• ATP
• Calcium
• Nucleotide
• cell membrane
• metabolism
• mitochondria
• pharmacology
• phosphorylation
• protein
• receptor
• synthesis

• McMaster University, Hamilton, Canada

  A. K. Grover, E. E. Daniel

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