Hormones and Cancer

1. Front Matter

   Pages i-xix

   PDF

2. Underlying Mechanisms and Principles

   1. Front Matter

      Pages 1-2

      PDF

   2. Neoplastic Transformation: Oncogenes, Tumor Suppressors, Cyclins, and Cyclin-Dependent Kinases

      • Candace M. Howard, Antonio Giordano

      Pages 3-41

   3. TGF-β Inhibition of Intestinal Epithelial Cell Proliferation: G1 Cyclins, Cyclin-Dependent Kinases, and Cyclin Kinase Inhibitors

      • E. Aubrey Thompson, Tien C. Ko, R. Daniel Beauchamp

      Pages 43-71

   4. RET Proto-Oncogene and Its Role in Multiple Endocrine Neoplasia and Medullary Thyroid Cancer

      • Paul Goodfellow, Jeffrey F. Moley

      Pages 73-89

   5. The Nuclear Hormone Receptor Superfamily: Structure and Function

      • Xiaohua Leng, Sophia Y. Tsai, Ming-Jer Tsai

      Pages 91-126

   6. Retinoids: Concepts for Separation of Desirable and Undesirable Effects in the Treatment or Prevention of Cancer

      • Magnus Pfahl

      Pages 127-146

3. Breast Cancer

   1. Front Matter

      Pages 147-148

      PDF

   2. Clinical Aspects of Breast Cancer

      • William J. Gradishar, Monica Morrow

      Pages 149-195

   3. Genetics of Breast Cancer

      • Steven M. Hill, Diane M. Klotz, Claudia S. Cohn

      Pages 197-224

   4. Growth Factors and Modulation of Endocrine Response in Breast Cancer

      • Robert I. Nicholson, Julia M. W. Gee

      Pages 225-259

   5. Role of Altered Estrogen Receptors in Breast Cancer

      • Sami G. Diab, Carl G. Castles, Suzanne A. W. Fuqua

      Pages 261-281

   6. Progestins, Progesterone Receptors, and Breast Cancer

      • Kathryn B. Horwitz, Lin Tung, Glenn S. Takimoto

      Pages 283-306

   7. Molecular, Cellular, and Systemic Mechanisms of Antiestrogen Action

      • William H. Catherino, V. Craig Jordan

      Pages 307-355

   8. Aromatase Inhibitors and Breast Cancer

      • Angela M. H. Brodie

      Pages 357-376

4. Prostate Cancer

   1. Front Matter

      Pages 377-378

      PDF

   2. Current Concepts in the Treatment of Cancer of the Prostate

      • Joseph A. Smith Jr.

      Pages 379-394

   3. Tumor Suppressor Genes and Oncogenes in Human Prostate Cancer

      • Jill A. Macoska

      Pages 395-414

   4. Prostatic Growth Factors, Cancer, and Steroid Hormone Activity

      • Donna M. Peehl

      Pages 415-444

   5. Androgen Receptors in Human Prostate Cancer: Heterogeneous Expression, Gene Mutations, and Polymorphic Variants

      • Janette M. Hakimi, Rachel H. Rondinelli, Mark P. Schoenberg, Evelyn R. Barrack

      Pages 445-492

The series, Hormones in Health and Disease, was launched in 1993 to provide a scientific platform for investigators engaged in research on the biological actions of hormones and to anticipate relevance for their findings in clinical applications. The first volume of the series was dedicated to the discussion and understanding of molecular mechanisms by which steroid hormones influence target cells in normal and pathological conditions. With the diversity of information and the vast amount of literature on steroid hormone physiology, a more thorough treatment of Hormones and Cancer was identified as a timely topic. In this second volume in the series, Dr. Wayne V. Vedeckis has success­ fully undertaken the monumental task of editing the findings of the leading investigators in hormone and cancer research. Dr. Vedeckis brings to this project two decades of research experience in hormone action; he is actively engaged in elucidating hormone and cancer interrelations. It is a pleasure to welcome him to the series as an editor and congratulate him and all contribu­ tors in presenting this comprehensive treatise. The 20 chapters include discussions on contemporary topics relating control of cell division and signal transduction to the basic mechanisms of carcinogenesis by cloning patient genes, and recognizing the importance of steroid receptors in treatment protocols of various endocrine abnormalities.

• apoptosis
• biology
• cell division
• genes
• genetics
• molecular biology
• molecular mechanisms
• signal transduction
• therapy

• Department of Biochemistry and Molecular Biology, Louisiana State University Medical Center, New Orleans, USA

  Wayne V. Vedeckis

• Stanley S. Scott Cancer Center, New Orleans, USA

  Wayne V. Vedeckis

Policies and ethics