Recent Advances in Schizophrenia

1. Front Matter

   Pages i-xxv

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2. Conceptualization of Schizophrenia

   1. Front Matter

      Pages 1-1

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   2. Schizophrenia: Historical Perspectives

      • Anthony Kales, Joyce D. Kales, Antonio Vela-Bueno

      Pages 3-23

   3. On the Concept of Schizophrenia

      • Costas N. Stefanis

      Pages 25-57

   4. Modular Disjunction in Schizophrenia: A Framework for a Pathological Psychophysiology

      • John M. Cleghorn, Martin L. Albert

      Pages 59-80

   5. Meaning of Structural Changes in the Brain in Schizophrenia

      • Timothy J. Crow

      Pages 81-94

   6. Conceptual Approaches to the Study of Schizophrenia

      • William T. Carpenter Jr., Brian Kirkpatrick, Robert W. Buchanan

      Pages 95-113

3. Recent Advances in the Diagnosis and Treatment of Schizophrenia

   1. Front Matter

      Pages 115-115

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   2. Risk Factors in Schizophrenia: Interaction Between Genetic Liability and Environmental Factors

      • Fini Schulsinger, Josef Parnas

      Pages 117-129

   3. The Role of Molecular Genetics in Psychiatry: Unraveling the Etiology for Schizophrenia

      • Lynn E. Delisi, Michael Lovett

      Pages 131-161

   4. Diagnostic Advances in Anatomical and Functional Brain Imaging in Schizophrenia

      • Jörg J. Pahl, Victor W. Swayze, Nancy C. Andreasen

      Pages 163-189

   5. Risk Factors and Prevention in Schizophrenia

      • Michael J. Goldstein

      Pages 191-212

   6. Psychosocial Interventions in Schizophrenia

      • Kim T. Mueser, Robert P. Liberman, Shirley M. Glynn

      Pages 213-234

   7. Clozapine: Mechanism of Action in Relation to its Clinical Advantages

      • Herbert Y. Meltzer

      Pages 237-256

   8. Psychopharmacologic Treatment of Schizophrenia

      • John M. Kane

      Pages 257-276

4. Delivery Systems for Managing Schizophrenic Patients

   1. Front Matter

      Pages 277-277

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   2. Current Perspectives in the United States on the Chronically Mentally Ill

      • John A. Talbott

      Pages 279-295

   3. Policy on Chronic Mental Illness in Canada: Current Status and Future Directions

      • Gaston P. Harnois

      Pages 297-314

   4. Psychiatric Reform in Italy: Implications for the Treatment of Long-Term Schizophrenic Patients

      • Michele Tansella

      Pages 315-329

   5. Mental Health Services and New Research in England: Implications for the Community Management of Schizophrenia

      • Nicholas Tarrier, Christine Barrowclough

      Pages 331-351

I am honored to introduce readers to this extraordinary volume, the first in the annual International Perspectives Series: Psychiatry, Psychology, and Neurosciences. This particular volume on the Recent Advances In Schizophrenia stems from the Third Annual Pennsylvania Conference on Schizophrenia, held in March, 1988. At that international meeting, some of the most esteemed researchers in the field surveyed our current under­ standing of schizophrenia. Collectively, their presentations capture the excitement of a research field launching into a stage of rapid worldwide advancement. The last decade has seen an enormous refocusing of scientific effort on schizophrenia, directed, in large measure, by the National Institute of Mental Health (NIMH). Our understanding of this mysterious, disabling disorder in all its diversity has been enhanced by a host of technologies, including new neuroimaging techniques, cognitive psychology, molecular genetics, and anatomical, biochemical, and molecular neuropathology. The resulting growth spurt in our knowledge constitutes the essence of the conference and of this volume. As the following pages amply docu­ ment, it has been a decade of great progress, one in which we can take great pride. The science of our field has matured to the point that a major research thrust is now feasible-one likely to have enormous benefits for schizophrenic patients and their families. It is a very exciting time to be in this field and to participate in accelerating its advances.

• Syndrome
• behavior
• diagnosis
• psychiatry
• therapy

• Department of Psychiatry, Pennsylvania State University College of Medicine, Hershey, USA

  Anthony Kales

• Central Pennsylvania Psychiatric Institute, Pennsylvania State University College of Medicine, Hershey, USA

  Anthony Kales

• Department of Psychiatry, Athens University Medical School, Athens, Greece

  Costas N. Stefanis

• World Psychiatric Association, USA

  Costas N. Stefanis

• Department of Psychiatry, University of Maryland, School of Medicine, Baltimore, USA

  John A. Talbott

• Institute of Psychiatry and Human Behavior, University of Maryland Medical System, Baltimore, USA

  John A. Talbott

Policies and ethics