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Regulation of microRNAs

  • Book
  • © 2010

Overview

Editors:
  1. Helge Großhans

    1. Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland

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  • Reveals that the pri-miRNA processing complex undergoes autoregulation
  • Discusses the Trim-NHL protein family
  • Discusses HuR, an RNA-binding protein that regulates mRNAs through a number of mechanisms, including at least one instance in which HuR reverses miRNA-mediated mRNA silencing

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 700)

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Table of contents (12 chapters)

  1. Front Matter

    Pages i-xvi
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  2. microRNA Biogenesis and Function

    • René F. Ketting
    Pages 1-14

  3. Regulation of pri-miRNA Processing Through Smads

    • Akiko Hata, Brandi N. Davis
    Pages 15-27

  4. Stimulation of pri-miR-18a Processing by hnRNP A1

    • Gracjan Michlewski, Sonia Guil, Javier F. Cáceres
    Pages 28-35

  5. KSRP Promotes the Maturation of a Group of miRNA Precuresors

    • Michele Trabucchi, Paola Briata, Witold Filipowicz, Andres Ramos, Roberto Gherzi, Michael G. Rosenfeld
    Pages 36-42

  6. Hormonal Repression of miRNA Biosynthesis Through a Nuclear Steroid Hormone Receptor

    • Sally Fujiyama-Nakamura, Kaoru Yamagata, Shigeaki Kato
    Pages 43-55

  7. Autoregulatory Mechanisms Controlling the Microprocessor

    • Robinson Triboulet, Richard I. Gregory
    Pages 56-66

  8. Regulation of pre-miRNA Processing

    • Nicolas J. Lehrbach, Eric A. Miska
    Pages 67-75

  9. The Effect of RNA Editing and ADARs on miRNA Biogenesis and Function

    • Bret S. E. Heale, Liam P. Keegan, Mary A. O’Connell
    Pages 76-84

  10. miRNAs Need a Trim

    • F. Gregory Wulczyn, Elisa Cuevas, Eleonora Franzoni, Agnieszka Rybak
    Pages 85-105

  11. Properties of the Regulatory RNA-Binding Protein HuR and its Role in Controlling miRNA Repression

    • Nicole-Claudia Meisner, Witold Filipowicz
    Pages 106-123

  12. Turnover of Mature miRNAs and siRNAs in Plants and Algae

    • Heriberto Cerutti, Fadia Ibrahim
    Pages 124-139

  13. MicroRNases and the Regulated Degradation of Mature Animal miRNAs

    • Helge Großhans, Saibal Chatterjee
    Pages 140-155

  14. Back Matter

    Pages 157-161
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Keywords

About this book

Given this pervasiveness and importance of miRNA-mediated gene regulation, it should come as little surprise that miRNAs themselves are also highly regulated. However, the recent explosion of knowledge on this topic has been remarkable, providing a primary motivation for publication of this book. As miRNAs are transcribed by RNA polymerase II, the enzyme that also generates mRNAs, it was perhaps not unexpected that miRNA transcription would be subject to regulation, and we have willfully mitted this aspect from this monograph. However, what has been unexpected is the extent of post-transcriptional regulation of miRNAs that is illustrated in this book.

Editors and Affiliations

  • Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland

    Helge Großhans

About the editor

Helge Großhans, PhD is a research group leader at the Friedrich Miescher Institute for Biomedical Research (FMI), which is part of the Novartis Research Foundation in Basel, Switzerland. His main research interests are in the developmental function, regulation, and mechanism of action of microRNAs. He received his PhD from the University of Heidelberg and did his postdoctoral training at Yale University. He is the winner of a 2009 ERC Award.

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