Overview
- Editors:
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Charles Chalfant
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Department of Biochemistry, Virginia Commonwealth University, Richmond, USA
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Maurizio Del Poeta
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Department of Biochemistry, Medical University of South Carolina, Charleston, USA
- Includes a series of mouse animal models currently available for studying the role of sphingolipids in embryonic development, aging and a series of pathological processes
- Represents a comprehensive review of the current knowledge of sphingolipid signaling and that research scientists can use it as a reference for their studies
- Studies of sphingolipids in different system models
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Table of contents (19 chapters)
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- Christopher R. Gault, Lina M. Obeid, Yusuf A. Hannun
Pages 1-23
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- Laura Riboni, Paola Giussani, Paola Viani
Pages 24-45
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- Jacek Bielawski, Jason S. Pierce, Justin Snider, Barbara Rembiesa, Zdzislaw M. Szulc, Alicja Bielawska
Pages 46-59
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- Johnny Stiban, Rotem Tidhar, Anthony H. Futerman
Pages 60-71
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- Joost C. M. Holthuis, Chiara Luberto
Pages 72-85
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- Mariana N. Nikolova-Karakashian, Krassimira A. Rozenova
Pages 86-108
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- Antonio Gómez-Muñoz, Patricia Gangoiti, MarÃa H. Granado, Lide Arana, Alberto Ouro
Pages 118-130
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- Vania Hinkovska-Galcheva, James A. Shayman
Pages 131-140
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- Graham M. Strub, Michael Maceyka, Nitai C. Hait, Sheldon Milstien, Sarah Spiegel
Pages 141-155
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- Maria C. Messner, Myles C. Cabot
Pages 156-164
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- Sandro Sonnino, Alessandro Prinetti
Pages 165-184
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- Babak Oskouian, Julie D. Saba
Pages 185-205
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- Ryan Rhome, Maurizio Del Poeta
Pages 232-237
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- Kai Zhang, James D. Bangs, Stephen M. Beverley
Pages 238-248
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- Simone Zäuner, Philipp Ternes, Dirk Warnecke
Pages 249-263
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- Eberhard O. Voit, Fernando Alvarez-Vasquez, Yusuf A. Hannun
Pages 264-275
About this book
This book attempts to analyze the latest discoveries in sphingolipid biology and how the alteration of their metabolism leads to altered signaling events and to the development of pathobiological disorders, such as cancer, cardiovascular diseases, asthma, diabetes, inflammation and infectious diseases.
Editors and Affiliations
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Department of Biochemistry, Virginia Commonwealth University, Richmond, USA
Charles Chalfant
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Department of Biochemistry, Medical University of South Carolina, Charleston, USA
Maurizio Del Poeta
About the editors
CHARLES CHALFANT is a tenured Associate Professor of Biochemistry and Molecular Biology at Virginia Commonwealth University-School of Medicine. He is also a Research Career Scientist in the Veterans Administration based at the Hunter Holmes McGuire Veterans Administration Medical Center in Richmond, Virginia. His main research interests lie in lipid signaling, specifically the role of intracellular lipid second messengers (e.g., ceramide-1-phosphate) in regulating eicosanoid synthesis. He also studies the role of oncogenic signaling pathways in regulating the alternative splicing of tumor suppressor genes such as caspase 9. Dr. Chalfant serves on the Editorial Board of The Journal of Lipid Research as well as on several National Panels of Scientific Review including formal membership on the Cancer Molecular Pathobiology Study Section for the National Institutes of Health and the Oncology A Study Section for the Veterans Administration. He received his PhD degree from the University of South Florida-College of Medicine and did his postdoctoral studies at Duke University and the Medical University of South Carolina.
MAURIZIO DEL POETA , MD is a tenured Associate Professor of Biochemistry and Molecular Biology, Microbiology and Immunology, Craniofacial Biology, and for the Division of Infectious Diseases at the Medical University of South Carolina, Charleston, South Carolina, USA. He is also the Director of the Graduate Program in Biochemistry and Molecular Biology at MUSC. Main research interests include the study of the role of sphingolipids in fungal pathogenesis and the development of new diagnostic and therapeutic strategies against fungal infections. He received many awards for his research discoveries and teaching. He is also a member of
many national and international societies such as the American Society for Clinical Investigation (ASCI), the American Society for Biochemistry and Molecular Biology, and the American Society for Microbiology. Dr. Del Poeta isa Burroughs Wellcome New Investigator in the Pathogenesis of Infectious Diseases.
