Polyploidization and Cancer

1. Front Matter

   Pages i-xv

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2. Polyploidy, Aneuploidy and the Evolution of Cancer

   • Lauren M.F. Merlo, Li-san Wang, John W. Pepper, Peter S. Rabinovitch, Carlo C. Maley

   Pages 1-13

3. Molecular Mechanisms and Function of the Spindle Checkpoint, a Guardian of the Chromosome Stability

   • Daisuke Ito, Tomohiro Matsumoto

   Pages 15-26

4. Understanding Cytokinesis Failure

   • Guillaume Normand, Randall W. King

   Pages 27-55

5. DNA Damage and Polyploidization

   • Jeremy P.H. Chow, Randy Y.C. Poon

   Pages 57-71

6. Role of the p53 Family in Stabilizing the Genome and Preventing Polyploidization

   • Flaminia Talos, Ute M. Moll

   Pages 73-91

7. Centrosomes, Polyploidy and Cancer

   • Anette Duensing, Stefan Duensing

   Pages 93-103

8. Polyploidy: Mechanisms and Cancer Promotion in Hematopoietic and Other Cells

   • Hao G. Nguyen, Katya Ravid

   Pages 105-122

9. Polyploidization of liver cells

   • Séverine Celton-Morizur, Chantal Desdouets

   Pages 123-135

10. Analysis of Cellular DNA Content by Flow and Laser Scanning Cytometry

    • Zbigniew Darzynkiewicz, H. Dorota Halicka, Hong Zhao

    Pages 137-147

11. Back Matter

    Pages 149-151

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Limiting genome replication to once per cell cycle is vital for maintaining genome stability. Although polyploidization is of physiologically importance for several specialized cell types, inappropriate polyploidization is believed to promote aneuploidy and transformation. A growing body of evidence indicates that the surveillance mechanisms that prevent polyploidization are frequently perturbed in cancers. Progress in the past several years has unraveled some of the underlying principles that maintain genome stability. This book brings together leaders of the field to overview subjects relating to polyploidization and cancer.

• Chromosom
• DNA
• carcinogenesis
• cell
• cytokines
• esophagus
• laser
• liver
• proteins
• tumor
• tumorigenesis

• Department of Biochemistry, Hong Kong University of Science and Technology Clear Water Bay, Hong Kong, China

  Randy Y. C. Poon

Randy Y.C. Poon is a professor of Biochemistry at the Hong Kong University of Science and Technology. He was educated at Tonbridge School and received his Master of Arts degree from St. Catharine’s College at the University of Cambridge. He then studied for a Doctor of Philosophy degree at the University of Cambridge and Cancer Research UK with Tim Hunt, FR S. Dr. Poon conducted postdoctoral training at the Salk Institute with Tony Hunter, FR S. Dr. Poon is a member of Editorial Board of numerous international journals, including the Biochemical Journal and Cancer Biology and Therapy. His research interests focus on understanding the molecular basis of cell cycle control in normal and cancer cells.

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