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Polyploidization and Cancer

  • Book
  • © 2010

Overview

Editors:
  1. Randy Y. C. Poon

    1. Department of Biochemistry, Hong Kong University of Science and Technology Clear Water Bay, Hong Kong, China

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  • Gives overview on subjects related to polyploidization and cancer
  • Examples of polyploidization including hematopoietic cells and liver cells
  • State-of-the-art methodologies on how ploidy can be measured

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 676)

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Table of contents (9 chapters)

  1. Front Matter

    Pages i-xv
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  2. Polyploidy, Aneuploidy and the Evolution of Cancer

    • Lauren M.F. Merlo, Li-san Wang, John W. Pepper, Peter S. Rabinovitch, Carlo C. Maley
    Pages 1-13

  3. Molecular Mechanisms and Function of the Spindle Checkpoint, a Guardian of the Chromosome Stability

    • Daisuke Ito, Tomohiro Matsumoto
    Pages 15-26

  4. Understanding Cytokinesis Failure

    • Guillaume Normand, Randall W. King
    Pages 27-55

  5. DNA Damage and Polyploidization

    • Jeremy P.H. Chow, Randy Y.C. Poon
    Pages 57-71

  6. Role of the p53 Family in Stabilizing the Genome and Preventing Polyploidization

    • Flaminia Talos, Ute M. Moll
    Pages 73-91

  7. Centrosomes, Polyploidy and Cancer

    • Anette Duensing, Stefan Duensing
    Pages 93-103

  8. Polyploidy: Mechanisms and Cancer Promotion in Hematopoietic and Other Cells

    • Hao G. Nguyen, Katya Ravid
    Pages 105-122

  9. Polyploidization of liver cells

    • Séverine Celton-Morizur, Chantal Desdouets
    Pages 123-135

  10. Analysis of Cellular DNA Content by Flow and Laser Scanning Cytometry

    • Zbigniew Darzynkiewicz, H. Dorota Halicka, Hong Zhao
    Pages 137-147

  11. Back Matter

    Pages 149-151
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Keywords

About this book

Limiting genome replication to once per cell cycle is vital for maintaining genome stability. Although polyploidization is of physiologically importance for several specialized cell types, inappropriate polyploidization is believed to promote aneuploidy and transformation. A growing body of evidence indicates that the surveillance mechanisms that prevent polyploidization are frequently perturbed in cancers. Progress in the past several years has unraveled some of the underlying principles that maintain genome stability. This book brings together leaders of the field to overview subjects relating to polyploidization and cancer.

Editors and Affiliations

  • Department of Biochemistry, Hong Kong University of Science and Technology Clear Water Bay, Hong Kong, China

    Randy Y. C. Poon

About the editor

Randy Y.C. Poon is a professor of Biochemistry at the Hong Kong University of Science and Technology. He was educated at Tonbridge School and received his Master of Arts degree from St. Catharine’s College at the University of Cambridge. He then studied for a Doctor of Philosophy degree at the University of Cambridge and Cancer Research UK with Tim Hunt, FR S. Dr. Poon conducted postdoctoral training at the Salk Institute with Tony Hunter, FR S. Dr. Poon is a member of Editorial Board of numerous international journals, including the Biochemical Journal and Cancer Biology and Therapy. His research interests focus on understanding the molecular basis of cell cycle control in normal and cancer cells.

Bibliographic Information

  • Book Title: Polyploidization and Cancer

  • Editors: Randy Y. C. Poon

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-1-4419-6199-0

  • Publisher: Springer New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 2010

  • Hardcover ISBN: 978-1-4419-6198-3Published: 21 May 2010

  • Softcover ISBN: 978-1-4939-5143-7Published: 23 August 2016

  • eBook ISBN: 978-1-4419-6199-0Published: 11 January 2011

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: XV, 151

  • Topics: Biomedicine general

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