Overview
- Presents a series of essays on cellular models that have been studied
- Gives a brief historical background, summarizes the elements of integrin structure and outlines the main biological problems that involve signal transduction between the cell adhesion machinery and ion channels
- Provides a primer to the structure and physiology of the most relevant ion channel types
- Surveys recent views about intracellular signaling triggered by integrin activation, with special emphasis on tyrosine phosphorylation cascades and the relationship with growth factors and cytokines
- Reviews current technology for studying the molecular complexes formed by integral membrane proteins
Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 674)
Access this book
Tax calculation will be finalised at checkout
Other ways to access
Table of contents (10 chapters)
-
Front Matter
-
Back Matter
Keywords
About this book
Editors and Affiliations
About the editors
ANDREA BECCHETTI, PhD, is Professor of General, Comparative and Cellular Physiology at the Department of Biotechnology and Biosciences of the University of Milano-Bicocca, Italy. After receiving his academic degrees at the University of Milan, he has spent prolonged research sojourns at the Department of General Pathology of the University of Florence, Italy, the Department of Physiology at Emory University in Atlanta, Georgia, USA, the Department of Physiological Sciences of the University of Newcastle upon Tyne, UK, and the Biophysics Sector of the International School for Advanced Studies (ISAS-SISSA), in Trieste, Italy.
His current research interests include the role of ion channels in cell adhesion and proliferation, the nicotinic modulation of synaptic transmission in the mammalian cerebral cortex and the pathogenesis of sleep-related epileptic forms linked to mutant human nicotinic receptors. Andrea Becchetti is member of the Society of General Physiologists, Biophysical Society, Society for Neuroscience and the Italian Physiological Society.
ANNAROSA ARCANGELI, MD, PhD is Professor of General Pathology and Immunology at the Department of Experimental Pathology and Oncology of the University of Firenze (Florence, Italy). She is the Scientific Director of the Laboratory of Genetic Engineering for the Production of Animal Models of the University of Firenze. After receiving her MD degree at the University of Firenze, she spent several research sojourns at the Department of Physiology of the University of Milano, at the Institut d’Embriologie Cellulaire et Moleculaire, Nogent sur Marne, Paris, France and at the MRC-LMB Centre of Cambridge, UK. Her main research interests include the role of ion channels, in particular potassium channels, in the regulation of different aspects of tumor cell behaviour, including the cross talk with adhesion receptors, as well as the identification of ion channels as novel targetsfor cancer therapy. Annarosa Arcangeli is member of the Italian Society of Pathology, the Association of Cell Biology and Differentiation (ABCD), the American Society of Hematology.
Bibliographic Information
Book Title: Integrins and Ion Channels
Book Subtitle: Molecular Complexes and Signaling
Editors: Andrea Becchetti, Annarosa Arcangeli
Series Title: Advances in Experimental Medicine and Biology
DOI: https://doi.org/10.1007/978-1-4419-6066-5
Publisher: Springer New York, NY
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 2010
Hardcover ISBN: 978-1-4419-6065-8Published: 12 April 2010
Softcover ISBN: 978-1-4614-2583-0Published: 27 May 2012
eBook ISBN: 978-1-4419-6066-5Published: 28 December 2010
Series ISSN: 0065-2598
Series E-ISSN: 2214-8019
Edition Number: 1
Number of Pages: XX, 124
Number of Illustrations: 23 b/w illustrations
Topics: Biomedicine general