Overview
- Introduction to current knowledge of extracellular and intracellular NCAM ligands and the structural basis of NCAM interactions with the fibroblast growth factor (FGF) receptor
- Chapters are grouped into sections reflecting various aspects of NCAM structure and function, making for a straightforward approach to NCAM
- Explores new therapeutic potential of NCAM mimetics
Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 663)
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Table of contents (26 chapters)
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Front Matter
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Structure and Ligands of NCAM
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Front Matter
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NCAM-Mediated Signal Transduction
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Front Matter
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NCAM-mediated Signal Transduction
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NCAM Metabolism
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Front Matter
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Keywords
About this book
Adhesive interactions are important for cell trafficking, differentiation, function and tissue formation. In the nervous system, many cell adhesion molecules (CAMs) are involved in migration of neuroblasts, outgrowth and fasciculation of neuronal processes, formation of synapses and rearrangements of synaptic contacts associated with plasticity including learning and memory. More than eighty CAMs were found to be localized at synaptic sites, where they in a regulated manner bridge pre- and postsynaptic specializations thereby modulating synaptic function. Structure and Function of the Neural Cell Adhesion Molecule NCAM describes recent developments concerning structural, functional and possible therapeutic aspects of one particular CAM, the neural cell adhesion molecule (NCAM). NCAM is one of the first identified and most studied CAMs, and this book is the first attempt to collectively summarize our current knowledge of this important cell adhesion molecule.
Editors and Affiliations
Bibliographic Information
Book Title: Structure and Function of the Neural Cell Adhesion Molecule NCAM
Editors: Vladimir Berezin
Series Title: Advances in Experimental Medicine and Biology
DOI: https://doi.org/10.1007/978-1-4419-1170-4
Publisher: Springer New York, NY
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 2010
Hardcover ISBN: 978-1-4419-1169-8Published: 22 December 2009
Softcover ISBN: 978-1-4614-2545-8Published: 25 February 2012
eBook ISBN: 978-1-4419-1170-4Published: 17 December 2009
Series ISSN: 0065-2598
Series E-ISSN: 2214-8019
Edition Number: 1
Number of Pages: XVI, 434
Number of Illustrations: 22 b/w illustrations, 45 illustrations in colour
Topics: Neurosciences, Human Physiology, Neurobiology, Neurochemistry