Narcolepsy

1. Front Matter

   Pages i-xxii

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2. Etiology

   1. Front Matter

      Pages 1-1

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   2. Narcolepsy: Genetic Predisposition and Pathophysiology

      • Emmanuel Mignot

      Pages 3-21

   3. Animal Models of Narcolepsy: Development, Findings and Perspectives

      • Christopher M. Sinton

      Pages 23-37

   4. Neuroimaging of Narcolepsy

      • Eric A. Nofzinger

      Pages 39-43

3. Clinical Considerations

   1. Front Matter

      Pages 46-46

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   2. Epidemiology of Narcolepsy

      • Lauren Hale

      Pages 47-53

   3. Narcolepsy in Childhood

      • Suresh Kotagal, Shalini Paruthi

      Pages 55-67

   4. Narcolepsy in the Older Adult

      • Hrayr Attarian

      Pages 69-76

   5. Diurnal and Nocturnal Sleep in Narcolepsy with Cataplexy

      • Yves Dauvilliers, Giuseppe Plazzi

      Pages 77-85

   6. Hypnagogic Hallucinations and Sleep Paralysis

      • Armando D’Agostino, Ivan Limosani

      Pages 87-97

   7. REM Sleep Behavior Disorder in Narcolepsy with Cataplexy

      • Giuseppe Plazzi, Yves Dauvilliers

      Pages 99-103

   8. Narcolepsy and Other Comorbid Medical Illnesses

      • Lori A. Panossian, Alon Y. Avidan

      Pages 105-113

   9. Humor Processing in Human Narcolepsy with Cataplexy

      • Aurélie Ponz, Sophie Schwartz

      Pages 115-124

   10. Dreams in Patients with Narcolepsy

       • Michael Schredl

       Pages 125-127

   11. Psychoanalysis and Narcolepsy

       • J. F. Pagel, Lawrence Scrima

       Pages 129-134

   12. Symptomatic Narcolepsy or Hypersomnia, with and Without Hypocretin (Orexin) Deficiency

       • T. Kanbayashi, M. Nakamura, T. Shimizu, S. Nishino

       Pages 135-165

   13. Hypersomnias Other than Narcolepsy: Differential Diagnosis

       • Michel Billiard

       Pages 167-178

4. Psychosocial Considerations

   1. Front Matter

      Pages 180-180

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   2. Psychosocial Impact of Narcolepsy in Children and Adolescents

      • Gregory Stores

      Pages 181-187

Narcolepsy serves as a prototype of how the interaction of high quality clinical research and groundbreaking basic science can collaborate to defne the cause of a disease and change forever how we evaluate and treat it. There is scarcely a topic in this book that would have been covered in the same way 10 years ago as it is d- cussed today. We are also fortunate that many of the players in this dramatic tu- around have contributed to this volume, so that the result is a tapestry of the events that have transformed the feld over the last decade that is both authentic and detailed. The frst section of the book provides much of the basic science background. As described in the frst two chapters, the dramatic convergence of lines of evidence from two different laboratories frst demonstrated in 1999 that narcolepsy is a disease of loss of neurotransmission by lateral hypothalamic neurons making the peptides that have been called orexins or hypocretins. These fndings did much to clarify and unify a feld that had puzzled for decades over the fundamental nature of this puzzling disease, as refected in the chapters that review its epidemiology and neuroanatomical and imaging fndings.

• attention
• cataplexy
• daytime sleepiness
• diagnosis
• hypersomnias
• hypnagogic
• hypnopompic hallucinations
• modafinil
• narcolepsy
• psychoanalysis
• sleep medicine
• sleep paralysis
• sodium oxybate

From the reviews: “This book brings together prominent clinicians and scientists from a variety of disciplines to discuss current issues and future directions in a specific area of sleep medicine, narcolepsy. … The book is targeted primarily at sleep clinicians and researchers, psychiatrists, neurologists, psychologists, social workers, behavioral scientists, and graduate medical students … . a significant contribution to the field of sleep medicine. It is one of the first books to bring together prominent clinicians and researchers in the field to focus specifically and comprehensively on narcolepsy.” (M. Isabel L. Crisostomo, Doody’s Review Service, July, 2010)

• Narcolepsy Institute, Montefiore Medical Center, Bronx, U.S.A.

  Meeta Goswami

• Dept. Pharmacology, Columbia University, New York, U.S.A.

  S. R. Pandi-Perumal

• Sleep-Wake Disorders Center, Montefiore Hospital, Bronx, U.S.A.

  Michael J. Thorpy

Meeta Goswami, BDS, PhD, MPH, has been the director of the Narcolepsy Institute since its inception in 1985 and serves as an Assistant Professor of Neurology, Albert Einstein College of Medicine. Her general area of research interest includes narcolepsy and psychosocial issues.

S.R. Pandi-Perumal, M.Sc, is the President and Chief Executive Officer of Somnogen Inc, a New York Corporation. He is a well-recognized sleep researcher both nationally and internationally, and has authored many publications. His general area of research interest includes sleep and biological rhythms. He is a well-known editor in the field of sleep medicine and has edited over 15 volumes dealing with various sleep-related topics.

Michael J Thorpy, MD, has won many awards for his research including one of the sleep field's highest honors: the Nathaniel Kleitman Award. He is a well-published researcher and a board-certified sleep physician. He serves as a Professor of Neurology at Albert Einstein College of Medicine and the Director of the Sleep-Wake Disorders Center at Montefiore Medical Center, Bronx, New York.

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