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  • © 2009

Mechanosensitivity of the Nervous System

  • For the first time one volume brings together a comprehensive up-to-date description of mechanosensitive ion channels in the nervous cells
  • For the first time one volume provides a throughout review of mechanosensitivity of the receptors, present in the nervous system
  • For the first time it gives a reader a complete overview of biomechanics of the nervous system
  • First of a kind, it gives a wide and detailed coverage of mechanosensitivity of neurovascular system
  • This is the only single source which provides the most modern vision of known mechanosensitive signaling cascades in the nervous system

Part of the book series: Mechanosensitivity in Cells and Tissues (MECT, volume 2)

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Table of contents (15 chapters)

  1. Front Matter

    Pages I-XXII
  2. Mechanosensitivity of Nervous Cells

    1. Front Matter

      Pages 1-1
    2. Ion Channels with Mechanosensitivity in the Nervous System

      • Gehoon Chung, Seog Bae Oh
      Pages 23-49
    3. Mechanosensitive Cation Currents and their Molecular Counterparts in Mammalian Sensory Neurons

      • Jizhe Hao, Matthieu Raoux, Nathalie Azorin, Lise Rodat-Despoix, Aurélie Giamarchi, François Maingret et al.
      Pages 51-67
  3. Mechanosensitivity of the Receptors

    1. Front Matter

      Pages 105-105
    2. Mechanosensitivity of the Cochlea

      • Keiji Tabuchi, Akira Hara
      Pages 107-113
    3. Osmoreceptors in Cochlear Outer Hair Cells

      • Narinobu Harada
      Pages 115-131
    4. Are Stretch-Activated Channels an Ocular Barometer?

      • James C.H. Tan, Minas T. Coroneo
      Pages 133-144
    5. Neuromodulation of Mechanosensory Input to the Insect CNS

      • Belauh Leitch, Robert M. Pitman
      Pages 145-170
  4. Biomechanic of Nervous System

    1. Front Matter

      Pages 171-171
    2. Biomechanics of the CNS

      • Kristian Franze, Andreas Reichenbach, Josef Käs
      Pages 173-213
    3. Mechanical Properties of Brain Tissue: Characterisation and Constitutive Modelling

      • J.A.W. van Dommelen, M. Hrapko, G.W.M. Peters
      Pages 249-279
    4. Role of Falx on Brain Stress-Strain Responses

      • Narayan Yoganandan, Jianrong Li, Jiangyue Zhang, Frank A. Pintar
      Pages 281-297
    5. Exercise and Nervous System

      • Kazuhiro Imai, Hiroyuki Nakajima
      Pages 299-318
  5. Mechanosensitivity of Neurovascular System

    1. Front Matter

      Pages 319-319

About this book

This book presents the latest findings in mechanosensitivity of the nervous system. The nervous system stands out from a number of tissues because besides reacting to the mechanical stress it is transmitting its own response to other organs and tissues, which are located downstream of its signaling pathway. For this reason any type of mechanical stimulation of the nervous system, which is capable of triggering a physiological response, has high scientific and practical significance, since it allows its use beyond a particular experimental model anywhere where it is contributing to a particular pathological condition.

This book is a unique collection of reviews outlining the current knowledge and the future developments in this rapidly growing field. Currently, investigations of the effects of mechanical stress on the nervous system are focused on several issues. The majority of studies investigate the effects of mechanical stimulation on mechanosensitive channels, as its primary target and interactive agent, and aim on description of downstream intracellular signaling pathways together with addressing general issues of biomechanics of the nervous system. Knowledge of biomechanics, and mechanisms, which underlie it on organism, organ, tissue and cellular level, is necessary for understanding of the normal functioning of living organisms and allows to predict changes which arise due to alterations of their environment, and possibly will allow to develop new methods of artificial intervention.

The book brings up the problem closer to the experts in related medical and biological sciences as well as practicing doctors besides just presenting the latest achievements in the field.

Editors and Affiliations

  • Dept. Fundamental & Applied Physiology, Russian State Medical University, Russia 117997

    Andre Kamkim, Irina Kiseleva

Bibliographic Information

Buy it now

Buying options

eBook USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access