Molecular Basis of Thyroid Cancer

1. Front Matter

   Pages i-vii

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2. The Origin of Cancer

   • Evan Y. Yu, William C. Hahn

   Pages 1-22

3. The Pathology of Thyroid Cancer

   • Sylvia L. Asa

   Pages 23-68

4. Thyroid Lymphomas

   • Runjan Chetty

   Pages 69-84

5. Molecular Events in Follicular Thyroid Tumors

   • Todd G. Kroll

   Pages 85-106

6. Molecular Epidemiology of Thyroid Cancer

   • Martin Schlumberger

   Pages 107-120

7. Growth Factors and their Receptors in the Genesis and Treatment of Thyroid Cancer

   • Shereen Ezzat

   Pages 121-130

8. Biology of Ras in Thyroid Cells

   • Judy L. Meinkoth

   Pages 131-148

9. P53 and other Cell Cycle Regulators

   • Nadir R. Farid

   Pages 149-164

10. Abnormalities of Nuclear Receptors in Thyroid Cancer

    • Sheue-Yann Cheng

    Pages 165-178

11. Matrix Metalloproteinases in Thyroid Cancer

    • Yufei Shi, Minjing Zou

    Pages 179-190

12. The Molecular Pathways Induced by Radiation and Leading to Thyroid Carcinogenesis

    • Yuri E. Nikiforov

    Pages 191-206

13. TRK Oncogenes in Papillary Thyroid Carcinoma

    • Angela Greco, Emanuela Roccato, Marco A. Pierotti

    Pages 207-219

14. Thyroidal Iodide Transport and Thyroid Cancer

    • Orsolya Dohán, Nancy Carrasco

    Pages 221-236

15. Molecular Signaling in Thyroid Cancer

    • Nicholas J. Sarlis, Salvatore Benvenga

    Pages 237-264

16. Gene Expression in Thyroid Tumors

    • Laszlo Puskas, Nadir R. Farid

    Pages 265-271

17. Animal Models of Thyroid Carcinogenesis

    • Carsten Boltze

    Pages 273-293

18. Diagnostic Molecular Markers in Thyroid Cancer

    • Matthew D. Ringel

    Pages 295-316

19. Thyroid Cancer Imaging

    • T. T. H. Phan, P. L. Jager, K. M. van Tol, T. P. Links

    Pages 317-343

20. Past, Presence and Future of Thyroid-Stimulating Hormone (TSH) Superactive Analogs

    • Mariusz W. Szkudlinski

    Pages 345-356

Thyroid cancer is the fastest growing cancer in the U.S., especially among women. Given the relative success we have had in its treatment, there is a need to capitalize on it by better understanding the factors that underpin this malignancy, and exploring better strategies for diagnosis, treatment, and follow-up. To do so, we must take full advantage of the revolution in modern biology. This comprehensive volume addresses the needs of a broad readership. Against a backdrop of the complexity of the origins of cancer, pathology of thyroid tumors, including lymphomas, is discussed, as are molecular genetic lesions associated with spontaneous and radiation-related thyroid tumors, diagnostic tests available to surmise tumor subtypes (including a review of the potential of DNA micro arrays), advances in therapeutics (including recombinant hTSH superagonists, allowing for better treatment of well differentiated thyroid carcinoma and its imaging), and combinations of drugs that might influence the course of poorly differentiated and anaplastic thyroid cancer. In this book, we glimpse into the promise of gene therapy in the future management of otherwise lethal anaplastic and poorly differentiated thyroid tumors. The molecular genetics of medullary thyroid cancer is considered in depth, and malignancy is used as a showcase for genetic prediction and counseling.

• carcinogenesis
• carcinoma
• cell
• gene therapy
• growth
• growth factor
• hormone
• hormones
• imaging
• lymphoma
• nuclear receptors
• pathology
• protein

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Reviewer’s Expert Opinion: Ronald N Cohen, MD (University of Chicago Medical Center)

This book discusses and evaluates recent advances in the molecular basis of the pathogenesis and treatment of the various forms of thyroid cancer. The purpose is to convey a better understanding of the factors that cause thyroid cancer, as well as to explore novel strategies for its treatment, focusing on recent advances in molecular biology. There is a significant, and rapidly-growing, literature concerning the molecular biology of thyroid cancer, and this book is a welcome addition that allows these novel findings to be placed in perspective. There will be a relatively narrow audience for this book. In particular, it will appeal significantly more to thyroidologists than to general endocrinologists. In addition, it will be interesting to nuclear medicine physicians, pathologists, and oncologists if they have a specific interest in thyroid cancer. The book covers a wide range of topics, ranging from the pathology of thyroid tumors to specific molecular events in the pathogenesis of thyroid cancer. In this process, chapters devoted to specific molecules important in thyroid cancer are included. In addition, information on NIS, and how it relates to thyroid cancer imaging and treatment is discussed in detail. Finally, molecular genetics, for example the genetics of medullary thyroid cancer, is also included. The chapters are well written and informative, though there is occasional overlap. For physicians and scientists with a significant interest in thyroid cancer, this book is a welcome addition. It provides a wealth of interesting information, and I enjoyed it very much.

• Osancor Biotech, Inc., Watford, UK

  Nadir R. Farid

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