Skip to main content
SpringerLink
Log in

Somatostatin

  • Textbook
  • © 2004

Overview

Editors:
  1. Coimbatore B. Srikant

    1. Department of Medicine, McGill University Heath Center, Montréal, Canada

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Since the discovery of somatostatin barely 30 years ago, the mechanism of action of this ubiquitous peptide has been rigorously investigated.
  • This volume contains a comprehensive tour de force of advances in molecular, cellular, and physiologic aspects of somatostatin function and action, will be a useful resource for understanding current concepts of this hormone action, and also illuminates future directions for further investigation in this important area of peptide biology

Part of the book series: Endocrine Updates (ENDO, volume 24)

This is a preview of subscription content, log in via an institution to check access.

Access this book

Log in via an institution
eBook USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 54.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

Licence this eBook for your library

Institutional subscriptions

Table of contents (19 chapters)

  1. Front Matter

    Pages i-xvi
    Download chapter PDF

  2. Somatostatin-General Biology

    1. Somatostatin Gene Structure and Regulation

      • Mario Vallejo
      Pages 1-16

    2. Processing and Intracellular Targeting of Somatostatin

      • Rania Mouchantaf, Yogesh C. Patel, Ujendra Kumar
      Pages 17-27

    3. Cortistatin- A Novel Member of the Somatostatin Gene Family

      • Véronique Fabre, Avron D. Spier, Raphaëlle Winsky-Sommerer, José R. Criado, Luis de Lecea
      Pages 29-45

    4. Molecular Evolution of Somatostatin Genes

      • Hervé Tostivint, Michele Trabucchi, Mauro Vallarino, J. Michael Conlon, Isabelle Lihrmann, Hubert Vaudry
      Pages 47-64

    5. Altered Patterns of Growth Hormone Secretion in Somatostatin Knockout Mice

      • Malcolm J. Low, Marcelo Rubinstein, Veronica Otero-Corchon
      Pages 65-80

  3. Expression and Function of Somatostatin Receptors

    1. Somatostatin Receptor Gene Family - Subtype Selectivity for Ligand Binding

      • Jason P. Hannon, Christian Bruns, Gisbert Weckbecker, Daniel Hoyer
      Pages 81-106

    2. Expression of Somatostatin Receptors in Human Tissues in Health and Disease

      • Jean Claude Reubi, Beatrice Waser, Jean-Claude Schaer
      Pages 107-121

    3. Coexpression of Multiple Somatostatin Receptors in Individual Cells

      • Robert Gardette, Florence Petit, Stéphane Peineau, Christophe Lanneau, Jacques Epelbaum
      Pages 123-142

    4. Somatostatin Receptor Subtype Selectivity for Cytotoxic and Cytostatic Signaling

      • Coimbatore B. Srikant
      Pages 143-157

    5. Somatostatin Receptor Signaling via Protein Tyrosine Phosphatases

      • Hicham Lahlou, Julie Guillermet, Fabienne Vernejoul, Stéphane Pyronnet, Corinne Bousquet, Louis Buscail et al.
      Pages 159-167

    6. Expression and Function of Somatostatin and its Receptors in Immune Cells

      • David E. Elliott
      Pages 169-184

    7. Physiology of Somatostatin Receptors: From Genetics to Molecular Analysis

      • Hans-Jürgen Kreienkamp, Chong Wee Liew, Dietmar Bächner, Marie-Germaine Mameza, Michaela Soltau, Arne Quitsch et al.
      Pages 185-202

  4. Applications in Disease

    1. Somatostatin Receptor Imaging

      • Dik J. Kwekkeboom, Marion de Jong, Eric P. Krenning
      Pages 203-214

    2. Somatostatin Analogs in the Treatment of Pituitary Tumors

      • Annamaria Colao
      Pages 215-231

    3. Somatostatin Receptor Targeted-Radio-Ablation of Tumors

      • Marion de Jong, Roelf Valkema, Dik J Kwekkeboom, Eric P Krenning
      Pages 233-249

    4. Somatostatin Analogue Therapy of Neuro-Endocrine Gastro-Entero Pancreatic Tumors

      • Kjell Öberg
      Pages 251-270

    5. Vascular Effects of Somatostatin

      • Pekka Häyry, Einari Aavik
      Pages 271-288

    6. The Use of Somatostatin Analogues in Diabetic Retinopathy

      • Lois E. H. Smith, Maria B. Grant
      Pages 289-295

  5. The Future

    1. Somatostatin and its Receptors: Past, Present and the Future

      • Coimbatore B. Srikant
      Pages 297-302
Back to top

Keywords

About this book

Thirty years have passed since somatostatin was discovered and its hormonal function defined [1,2]. The wide range of anatomical distribution and actions of somatostatin and its receptors stimulated intense scientific and clinical interest, and fostered extensive research into all aspects of its biology including regulation of its gene expression, processing of its precursor, biological and cellular actions relating to regulation cell secretion, motility and proliferation. The development of metabolically stable peptide analogs helped define its usefulness in the treatment of endocrine diseases and cancer. The heterogeneity of somatostatin receptors recognized in 1981 [3] was later shown to result from the existence and variable expression of five distinct subtypes that constitutes two distinct subfamilies with distinguishing pharmacological characteristics [4,5]. The molecular cloning of these receptor subtypes reignited the interest in this field leading to a major increase in our insight into the biology of somatostatin and its receptor subtypes, and has led to the design and development of subtype-selective peptide and non-peptide agonists and antagonists. Significant progress has been made in both basic and clinical research on somatostatin. Noteworthy developments include the role of somatostatin in neuronal patterning, delineation of subtype-selective cytostatic / cytotoxic antiproliferative actions, manipulation of cellular signaling by oligomeric association of somatostatin receptor subtypes amongst themselves or with other G protein-coupled receptors, application of radionuclide-tagged derivatives to localize somatostatin receptor positive tumors and their treatment through targeted delivery of radionuclide or chemotoxin tagged agonists through receptor-mediated endocytosis.

Reviews

"Since the discovery of somatostatin barely 30 years ago, the mechanism of action of this ubiquitous peptide has been rigorously investigated. This volume contains a comprehensive tour de force of advances in molecular, cellular, and physiologic aspects of somatostatin function and action, will be a useful resource for understanding current concepts of this hormone action, and also illuminates future directions for further investigation in this important area of peptide biology."
(Shlomo Melmed, M.D., Series Editor, Endocrine Updates)

Editors and Affiliations

  • Department of Medicine, McGill University Heath Center, Montréal, Canada

    Coimbatore B. Srikant

Bibliographic Information

  • Book Title: Somatostatin

  • Editors: Coimbatore B. Srikant

  • Series Title: Endocrine Updates

  • DOI: https://doi.org/10.1007/b112847

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 2004

  • Hardcover ISBN: 978-1-4020-7799-9Published: 17 June 2004

  • Softcover ISBN: 978-1-4419-5440-4Published: 06 December 2010

  • eBook ISBN: 978-1-4020-8033-3Published: 11 April 2006

  • Series ISSN: 1566-0729

  • Edition Number: 1

  • Number of Pages: XVI, 311

  • Number of Illustrations: 28 b/w illustrations, 3 illustrations in colour

  • Topics: Pharmacology/Toxicology, Oncology

Publish with us

Policies and ethics

Back to top

Search

Navigation