Neuroactive Steroids in Brain Function, Behavior and Neuropsychiatric Disorders

1. Front Matter

   Pages i-xx

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2. Neuroactive Steroids and Brain Functions

   1. Neurosteroid: Molecular Mechanisms of Action on the GABAA Receptor

      • Ming-De Wang, Mozibur Rahman, Jessica Strömberg, Per Lundgren, David Haage, Inga-Maj Johansson et al.

      Pages 3-42

   2. Steroid Metabolism in Glial Cells

      • Roberto C. Melcangi, Luis Miguel Garcia-Segura

      Pages 43-59

   3. Involvement of Neuroactive Steroids in Hippocampal Disorders: Lessons from Animal Models

      • Alejandro F. De Nicola, Luciana Pietranera, Juan Beauquis, Françoise Homo-Delarche, Flavia E. Saravia

      Pages 61-87

   4. Estrogen Modulation of Visceral Nociception

      • Victor V. Chaban

      Pages 89-102

   5. Neuroactive Steroids: Effects on Cognitive Functions

      • Torbjörn Bückström, Vita Birzniece, Guillén Fernández, Inga-Maj Johansson, Kristiina Kask, Charlotte Lindblad et al.

      Pages 103-121

   6. Estrogen, Cholinergic System and Cognition

      • Sonsoles de Lacalle, Bryan Hyler, Thomas Borowski

      Pages 123-141

   7. Local Production of Estrogen and its Rapid Modulatory Action on Synaptic Plasticity

      • Suguru Kawato, Yasushi Hojo, Hideo Mukai, Gen Murakami, Mari Ogiue-Ikeda, Hirotaka Ishii et al.

      Pages 143-169

   8. Effects of Estradiol and DHEA on Morphological Synaptic Plasticity

      • Tibor Hajszan, Zsofia Hoyk, Luis Miguel Garcia-Segura, Arpad Parducz

      Pages 171-185

   9. Pregnane Steroids and Short-Term Neural Plasticity

      • Yuri B. Saalmann, Mike B. Calford

      Pages 187-200

   10. Steroidogenesis and Neuroplasticity in the Songbird Brain

       • Colin J. Saldanha, Barney A. Schlinger

       Pages 201-216

   11. Dehydroepiandrosterone, as Endogenous Inhibitor of Neuronal Cell Apoptosis: Potential Therapeutic Implications in Neurodegenerative Diseases

       • Ioannis Charalampopoulos, Christos Tsatsanis, Andrew N. Margioris, Elias Castanas, Achille Gravanis

       Pages 217-225

   12. DHEA and DHEA-S, and their Functions in the Brain and Adrenal Medulla

       • Alexander W. Krug, Christian G. Ziegler, Stefan R. Bornstein

       Pages 227-239

   13. Neurosteroids in the Aging Brain

       • Rael D. Strous

       Pages 241-248

3. Neuroactive Steroids and Neuropsychiatric Disorders

   1. Dehydroepiandrosterone and Pregnenolone Alterations in Schizophrenia

      • Michael S. Ritsner, Anatoly Gibel, Yael Ratner, Abraham Weizman

      Pages 251-297

   2. Neurosteroids in Cortical Development and the Etiology of Schizophrenia

      • Samantha S. Gizerian

      Pages 299-324

   3. Neurosteroid Perturbation and Neuropsychiatric Symptoms in Schizophrenia: From the Mechanisms to the Treatment

      • Flavia di Michele, Carlo Caltagirone, Gianfranco Spalletta

      Pages 325-335

   4. Dehydroepiandrosterone Administration in Treating Medical and Neuropsychiatric Disorders

      • Michael S. Ritsner

      Pages 337-368

   5. Allopregnanolone and Pregnenolone Alterations Following Pharmacological Agents in Rodents and Clinic Populations

      • Victoria M. Payne, Jason D. Kilts, Jennifer C. Naylor, Jennifer L. Strauss, Patrick S. Calhoun, Roger D. Madison et al.

      Pages 369-383

   6. Reconsidering Classifi cations of Depression Syndromes: Lessons from Neuroactive Steroids and Evolutionary Sciences

      • Bernardo Dubrovsky

      Pages 385-421

Over the past few decades the involvement of neurosteroids in brain function and mental health has attracted much interest, not only from a neuroscience perspective, but also from clinical and therapeutic aspects. In recent years, much of the research has focused on the multifunctional position of neurosteroids in the nervous system. The areas that have been explored, in particular, are the cellular and molecular mechanisms involved in the activity of neurosteroids in the brain, the role of neurosteroids in brain development, neurodegeneration and neuroplasticity, and their pharmacological properties. The large increase in the number of publications highlights this amplified interest in neurosteroids. Over the last 7 years at least 400 papers have been published describing the putative role of neurosteroids in the modulation of basic brain function and in the etiology and treatment of psychiatric and neurological disorders. Contributors to this book are amongst the most active basic researchers and c- nicians in the field and provide new perspectives not only clarifying some of the ongoing controversies, but also proposing diverse aspects and new insights. The book is organized in two major sections: “Neuroactive steroids and brain function’, and ‘Neuroactive steroids and neuropsychiatric disorders”. Though the selection of topics has been influenced by the current state of the art and the issues that require further elaboration, one should not assume that these are the only significant issues at this time.

• Depression
• Exploration
• Neurology
• Neuroscience
• Syndrom
• diagnosis
• steroids

From the reviews:

"This is a first rate book on an exciting area: steroids and the brain. … Written and edited by active researchers involved in this area of study, this book is a must for anyone interested in keeping abreast of this exploding field. … The targeted audience includes clinicians, researchers, and students. … This is an excellent, comprehensive book covering an important and emerging area of neuropsychiatric research. Anyone wishing to stay up to date on neurosteroids would benefit from reading it." (Michael J. Schrift, Doody’s Review Service, July, 2008)

"Neuroactive Steroids in Brain Function, Behavior, and Neuropsychiatric Disorders: Novel Strategies for Research and Treatment provides reviews on neurosteroid mechanisms of action, their role in brain function, and their probable therapeutic as well as contributory roles to neurodegenerative and psychiatric disorders. … is recommended for researchers interested in neurosteroids but also for clinicians who are able to devote enough time and attention to the material." (Catherine C. Price, PsycCRITIQUES, Vol. 53 (51), December, 2008)

• Sha'ar Menashe Mental Health Center, Israel

  Michael S. Ritsner

• Geha Mental Health Center, Israel

  Abraham Weizman

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