Myosins

1. Front Matter

   Pages I-XII

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2. The Structural And Functional Diversity Of The Myosin Family Of Actin-Based Molecular Motors

   • Mark S. Mooseker, Bernardo J. Foth

   Pages 1-34

3. Myosin Structure

   • Kenneth C. Holmes

   Pages 35-54

4. The Myosin Family: Biochemical And Kinetic Properties

   • Mohammed El-Mezgueldi, Clive R. Bagshaw

   Pages 55-93

5. Myosin I

   • Lynne M. Coluccio

   Pages 95-124

6. Myosin Ii: Sarcomeric Myosins, The Motors Of Contraction In Cardiac And Skeletal Muscles

   • Carlo Reggiani, Roberto Bottinelli

   Pages 125-169

7. Smooth-Muscle Myosin II

   • Christine R. Cremo, David J. Hartshorne

   Pages 171-222

8. Non-Muscle Myosin II

   • Mary Anne Conti, Sachiyo Kawamoto, Robert S. Adelstein

   Pages 223-264

9. Class III Myosins

   • ANDRÉA DOSÉ, Jennifer Lin-Jones, Beth Burnside

   Pages 265-287

10. Myosin V

    • James R. Sellers, Lois S. Weisman

    Pages 289-323

11. Myosin VI: A Multifunctional Motor Protein

    • Folma Buss, John Kendrick-Jones

    Pages 325-352

12. Myosin VII

    • Aziz El-Amraoui, Amel Bahloul, Christine Petit

    Pages 353-373

13. Plant Myosins VIII, XI, And XIII

    • Keiichi Yamamoto

    Pages 375-390

14. Class Ix Myosins

    • Martin BÄhler

    Pages 391-401

15. Myosin X

    • Melinda M. Divito, Richard E. Cheney

    Pages 403-419

16. Myosin Class XIV And Other Myosins In Protists

    • Karine FrÉnal, Bernardo J. Foth, Dominique Soldati

    Pages 421-440

17. Myosin XVA

    • Erich T. Boger, Gregory I. Frolenkov, Thomas B. Friedman, Inna A. Belyantseva

    Pages 441-467

18. Back Matter

    Pages 469-475

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Few would have predicted 20 years ago that myosins constitute a superfamily with at least two-dozen classes and that these molecular motors are involved in a multitude of intracellular activities including cell division, cell movement, intracellular transport and signal transduction. Application of state-of-the-art cellular and molecular biological, structural biological, genetic, biochemical and biophysical techniques has provided and continues to provide critical information regarding the structure–function relationship; and the cellular roles of various myosins in organisms as diverse as protozoa, yeast, plants and higher animals. The association of myosins with diseases including neurological disorders, immu- deficiencies, cardiomyopathies, hearing and vision loss testify to the importance of understanding the biochemical properties and cellular roles of myosins. The 16 chapters in this volume summarize the tremendous progress made in studying members of the myosin superfamily in recent years and offer critical insight into what future research will yield. I would like to express my sincere gratitude to the authors of this volume. It was a pleasure to work with each of you and I thank you for the considerable efforts in making this international endeavor possible. I also thank John Trinick from the University of Leeds, UK, for the elegant montage of images of single molecules of myosins on the cover, which beautifully shows the structures of some of these amazing molecules. The able assistance of Marlies Vlot from Springer and Indumadhi Srinivasan from Integra Software Services for production of the book is greatly appreciated.

• biological functions
• cell division
• migration
• molecular mechanisms
• proteins

• Boston Biomedical Research Institute, Watertown, USA

  Lynne M. Coluccio

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