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  • Book
  • © 2007

Chromatin and Disease

Editors:

  1. Tapas K. Kundu

    1. Jawaharlal Centre for Advanced Scientific Research, Jakkur, India

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  2. R. Bittman

    1. Queens College,City University of New York, New York

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  3. D. Dasgupta

    1. Saha Institute of Nuclear Physics, Calcutta

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  4. H. Engelhardt

    1. Max-Planck-Institute for Biochemistry, Munich

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  5. L. Flohe

    1. MOLISA GmbH, Magdeburg

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  6. H. Herrmann

    1. German Cancer Research Center, Heidelberg

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  7. A. Holzenburg

    1. Texas A & M University, Texas

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  8. H-P. Nasheuer

    1. National University of Ireland, Galway

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  9. S. Rottem

    1. The Hebrew University, Jerusalem

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  10. M. Wyss

    1. DSM Nutritional Products Ltd, Basel

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  11. P. Zwickl

    1. Max-Planck-Institute for Biochemistry, Munich

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  • Includes a collection of articles with the broad theme of disease connection to chromatin structure and function
  • Elaborates on the molecular pharmacology of the drugs targeting chromatin structure and its components
  • Contains up-to-date information about the chromatin structure and chromatin related diseases and drug functions

Part of the book series: Subcellular Biochemistry (SCBI, volume 41)

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Table of contents (18 chapters)

  1. Front Matter

    Pages I-XIII
    PDF

  2. Chromatin Structure, Dynamics and Disease

    1. Front Matter

      Pages 1-1
      PDF

    2. Structural Organization of Dynamic Chromatin

      • Kohji Hizume, Shige H. Yoshimura, Masahiro Kumeta, Kunio Takeyasu
      Pages 3-28

    3. ATP-dependent Chromatin Remodelling

      • Parul Choudhary, Patrick Varga-Weisz
      Pages 29-44

    4. Regulation of Chromatin Structure and Chromatin-Dependent Transcription by Poly(Adp-Ribose) Polymerase-1

      • David A. Wacker, Kristine M. Frizzell, Tong Zhang, W. Lee Kraus
      Pages 45-72

    5. Histone Variant Nucleosomes

      • Mathieu Boulard, Philippe Bouvet, Tapas K. Kundu, Stefan Dimitrov
      Pages 73-92

    6. Histone Variants and Complexes Involved in Their Exchange

      • Thomas Kusch, Jerry L. Workman
      Pages 93-110

    7. Histone Chaperones in Chromatin Dynamics

      • Jayasha Shandilya, Shrikanth Gadad, V. Swaminathan, Tapas K. Kundu
      Pages 111-124

    8. Functions Of The Histone Chaperone Nucleolin In Diseases

      • Sébastien Storck, Manu Shukla, Stefan Dimitrov, Philippe Bouvet
      Pages 125-144

    9. Chromatin as a Target for the DNA-Binding Anticancer Drugs

      • Parijat Majumder, Suman K. Pradhan, Pukhrambam Grihanjali Devi, Sudipta Pal, Dipak Dasgupta
      Pages 145-192

  3. Nonhistone Proteins, Sites for Epigenetic Marks: Link to Disease

    1. Front Matter

      Pages 191-191
      PDF

    2. Reversible Acetylation Of Non Histone Proteins

      • Kiran Batta, Chandrima Das, Shrikanth Gadad, Jayasha Shandilya, Tapas K. Kundu
      Pages 193-214

    3. MARs and MARBPs

      • Samit Chattopadhyay, Lakshminarasimhan Pavithra
      Pages 215-234

  4. Epigenetic Modifications of Chromatin: Implication in disease and therapeutics

    1. Front Matter

      Pages 231-231
      PDF

    2. Aberrant Forms of Histone Acetyltransferases in Human Disease

      • Olivier Van Beekum, Eric Kalkhoven
      Pages 235-268

    3. Chromatin Acetylation Status in the Manifestation of Neurodegenerative Diseases

      • Boutillier Anne-Laurence, Rouaux Caroline, Panteleeva Irina, Loeffler Jean-Philippe
      Pages 269-300

    4. Functions of Myst Family Histone Acetyltransferases and Their Link to Disease

      • Nikita Avvakumov, Jacques Côté
      Pages 301-322

    6. Regulation And Function Of H3K9 Methylation

      • Yoichi Shinkai
      Pages 341-354

    7. Histone Acetylation And Methylation

      • Woojin An
      Pages 355-374
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About this book

It is more evident now than ever before that dynamic organization of human genome into nucleoprotein structure, chromatin confers the unique regulatory mechanisms for most of the cellular phenomena, which include replication, transcription, DNA repair, recombination and also apoptosis. The dynamic nature of the chromatin is regulated by chromatin modifications (epigenetic alterations), remodeling, histone chaperones and functional interactions of different chromatin interacting n- histone proteins. Dysfunction of this highly inter connected machineries disturb the cellular homoeostasis, and thereby causes several diseases. As we advance in our knowledge of chromatin function and also disease mechanisms in more details, their causal relationship is becoming more evident. This has lead to the identification of chromatin function as target for new generation therapeutics. In the light of these advances, it happens to be the right time to explore current insights into various aspect of chromatin and disease connection under one cover. Authors who are actively involved in chromatin research and have made several original contributions to develop latest paradigms in the field have written the chapters of this book. Significantly, the authors’ repertoire is truly international. They come from eight different countries of Asia, Europe and America. The book has been divided into three different parts. Part I introduces the reader to the dynamic nature of chromatin structure and its link to diseases. First two chapters in this part deal with the chromatin architecture, chromatin dynamics in the cell cycle and molecular mechanism of chromatin remodeling.
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Keywords

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Editors and Affiliations

  • Jawaharlal Centre for Advanced Scientific Research, Jakkur, India

    Tapas K. Kundu

  • Queens College,City University of New York, New York

    R. Bittman

  • Saha Institute of Nuclear Physics, Calcutta

    D. Dasgupta

  • Max-Planck-Institute for Biochemistry, Munich

    H. Engelhardt, P. Zwickl

  • MOLISA GmbH, Magdeburg

    L. Flohe

  • German Cancer Research Center, Heidelberg

    H. Herrmann

  • Texas A & M University, Texas

    A. Holzenburg

  • National University of Ireland, Galway

    H-P. Nasheuer

  • The Hebrew University, Jerusalem

    S. Rottem

  • DSM Nutritional Products Ltd, Basel

    M. Wyss

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Bibliographic Information

  • Book Title: Chromatin and Disease

  • Editors: Tapas K. Kundu, R. Bittman, D. Dasgupta, H. Engelhardt, L. Flohe, H. Herrmann, A. Holzenburg, H-P. Nasheuer, S. Rottem, M. Wyss, … P. Zwickl

  • Series Title: Subcellular Biochemistry

  • DOI: https://doi.org/10.1007/1-4020-5466-1

  • Publisher: Springer Dordrecht

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Science+Business Media B.V. 2007

  • Hardcover ISBN: 978-1-4020-5465-5Published: 05 March 2007

  • Softcover ISBN: 978-90-481-7374-7Published: 11 November 2010

  • eBook ISBN: 978-1-4020-5466-2Published: 04 May 2007

  • Series ISSN: 0306-0225

  • Series E-ISSN: 2542-8810

  • Edition Number: 1

  • Number of Pages: XIV, 458

  • Topics: Biochemistry, general, Medical Microbiology, Virology

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Buy it now

eBook USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 219.00
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

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