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  • Book
  • © 2006

Statistics Applied to Clinical Trials

  • The authors have both medical and mathematical backgrounds
  • Based on famous modules from the Socrates educational project Eudipharm of the EC
  • Innovative because of the explanatory rather than mathematical approach
  • Emphasizes non-classical but increasingly frequently used methods such as equivalence testing, interaction assessment and analysis of genetic data
  • Not equivalent to any current textbook on statistics

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Table of contents (31 chapters)

  1. Front Matter

    Pages i-xv
  2. Hypotheses, Data, Stratification

    • Ton J. Cleophas, Aeilko H. Zwinderman, Toine F. Cleophas
    Pages 1-16
  3. The Analysis of Efficacy Data of Drug Trials

    • Ton J. Cleophas, Aeilko H. Zwinderman, Toine F. Cleophas
    Pages 17-39
  4. The Analysis of Safety Data of Drug Trials

    • Ton J. Cleophas, Aeilko H. Zwinderman, Toine F. Cleophas
    Pages 41-58
  5. Equivalence Testing

    • Ton J. Cleophas, Aeilko H. Zwinderman, Toine F. Cleophas
    Pages 59-65
  6. Statistical Power and Sample Size

    • Ton J. Cleophas, Aeilko H. Zwinderman, Toine F. Cleophas
    Pages 67-78
  7. Interim Analyses

    • Ton J. Cleophas, Aeilko H. Zwinderman, Toine F. Cleophas
    Pages 79-85
  8. Multiple Statistical Inferences

    • Ton J. Cleophas, Aeilko H. Zwinderman, Toine F. Cleophas
    Pages 87-96
  9. Controlling the Risk of False Positive Clinical Trials

    • Ton J. Cleophas, Aeilko H. Zwinderman, Toine F. Cleophas
    Pages 97-101
  10. The Interpretation of the P-Values

    • Ton J. Cleophas, Aeilko H. Zwinderman, Toine F. Cleophas
    Pages 103-115
  11. Research Data Closer to Expectation than Compatible with Random Sampling

    • Ton J. Cleophas, Aeilko H. Zwinderman, Toine F. Cleophas
    Pages 117-123
  12. Principles of Linear Regression

    • Ton J. Cleophas, Aeilko H. Zwinderman, Toine F. Cleophas
    Pages 125-140
  13. Subgroup Analysis Using Multiple Linear Regression: Confounding, Interaction, Synergism

    • Ton J. Cleophas, Aeilko H. Zwinderman, Toine F. Cleophas
    Pages 141-150
  14. Curvilinear Regression

    • Ton J. Cleophas, Aeilko H. Zwinderman, Toine F. Cleophas
    Pages 151-163
  15. Logistic and Cox Regression, Problems with Regression Modeling, Markow Models

    • Ton J. Cleophas, Aeilko H. Zwinderman, Toine F. Cleophas
    Pages 165-178
  16. Regression Modeling for Improved Precision

    • Ton J. Cleophas, Aeilko H. Zwinderman, Toine F. Cleophas
    Pages 179-185
  17. Post-Hoc Analyses in Clinical Trials, a Case for Logistic Regression Analysis

    • Ton J. Cleophas, Aeilko H. Zwinderman, Toine F. Cleophas
    Pages 187-191
  18. Interaction Effects in Clinical Trials

    • Ton J. Cleophas, Aeilko H. Zwinderman, Toine F. Cleophas
    Pages 193-204
  19. Meta-Analysis

    • Ton J. Cleophas, Aeilko H. Zwinderman, Toine F. Cleophas
    Pages 205-218
  20. Crossover Studies with Continuous Variables: Power Analysis

    • Ton J. Cleophas, Aeilko H. Zwinderman, Toine F. Cleophas
    Pages 219-228

Reviews

From the reviews of the fourth edition:

"Readership: Students, physicians and investigators interested in statistical methods for clinical trials. This book was originally written for a course in medical statistics given in the EU sponsored program European Interuniversity Diploma of Pharmaceutical Medicine starting in the year 2000. … it has been expanded and updated in order to serve as a guide and reference-text to students, physicians and investigators." (Andreas Rosenblad, International Statistical Review, Vol. 77 (3), 2009)

Authors and Affiliations

  • European Interuniversity College of Pharmaceutical Medicine Lyon, France

    Ton J. Cleophas

  • Department Medicine, Albert Schweitzer Hospital, Dordrecht, The Netherlands

    Ton J. Cleophas

  • Department Biostatistics and Epidemiology, Academic Medical Center Amsterdam, The Netherlands

    Aeilko H. Zwinderman

  • Technical University, Delft, The Netherlands

    Toine F. Cleophas

Bibliographic Information

Buy it now

Buying options

eBook USD 99.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Other ways to access