Overview
- Describes some of the most exciting developments for the discovery of new drugs, such as Fragment-based methods
- Includes supplementary material: sn.pub/extras
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Table of contents (9 chapters)
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Front Matter
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Back Matter
Keywords
About this book
Structure-based drug discovery methods have been transformed in the last 5-10 years and are now having a major impact on the discovery of new drugs. Some of the most exciting developments in the field, such as Fragment-based methods, are described in this book.
The book describes the latest developments in technologies that can be used to obtain the 3-D structures including the high profile structural genomics approaches being utilised worldwide. The use of 3-D protein structures in new, Fragment-based, approaches to drug discovery are described in some detail. This book includes experimental approaches using X-ray crystallography and NMR for Fragment-based screening as well as other biophysical methods for studying protein/ligand interactions. In addition, developments in computational chemistry methodology are covered together with an assessment of practical applications.
Reviews
From the reviews:
"Structure-based drug design (SBDD) is now an integral component of the drug discovery process. … The book’s core subject matter of fragment-based screening is an exciting and important development in drug discovery. These chapters are generally the strongest in the book and make it a good reference volume … ." (Robert Powers, Journal of the American Chemical Society, Vol. 129 (32), 2007)
Authors and Affiliations
Bibliographic Information
Book Title: Structure-based Drug Discovery
Authors: Harren Jhoti, Andrew R. Leach
DOI: https://doi.org/10.1007/1-4020-4407-0
Publisher: Springer Dordrecht
eBook Packages: Chemistry and Materials Science, Chemistry and Material Science (R0)
Copyright Information: Springer Science+Business Media B.V. 2007
Hardcover ISBN: 978-1-4020-4406-9Published: 09 January 2007
Softcover ISBN: 978-90-481-7123-1Published: 19 October 2010
eBook ISBN: 978-1-4020-4407-6Published: 24 May 2007
Edition Number: 1
Number of Pages: XII, 250
Topics: Medicinal Chemistry, Biomedicine general, Pharmacology/Toxicology, Biochemistry, general, Pharmacy, Physical Chemistry