Micrometastasis

1. Front Matter

   Pages i-x

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2. Technical Aspects of the Detection of Disseminated Tumour Cells by Molecular Methods

   • William H. Krüger

   Pages 1-18

3. RNA/DNA Based Detection of Minimal Residual Head and Neck Cancer

   • Ruud H. Brakenhoff

   Pages 19-45

4. Detection and Characterisation of Occult Metastatic Cells in Bone Marrow of Breast Cancer Patients: Implications for Adjuvant Therapy

   • Stephan Braun, Volkmar Müller, Klaus Pantel

   Pages 47-56

5. Prognosis of Minimal Residual Disease in Bone Marrow, Blood and Lymph Nodes in Breast Cancer

   • Debra Hawes, A. Munro Neville, Richard J. Cote

   Pages 67-85

6. Detection, Isolation and Study of Disseminated Prostate Cancer Cells in the Peripheral Blood and Bone Marrow

   • Jesco Pfitzenmaier, Robert L. Vessella, William J. Ellis, Paul H. Lange

   Pages 87-116

7. Early Disseminated Tumour Cells in Operable Non-Small Cell Lung Cancer

   • Bernward Passlick

   Pages 117-125

8. Prognostic Value of Minimal Residual Disease in Esophageal Cancer

   • Peter Scheuemann, Stefan B. Hosch, Jacob R. Izbicki

   Pages 127-138

9. Clinical Relevance of Tumor Cell Dissemination in Colorectal, Gastric and Pancreatic Carcinoma

   • Ilka Vogel, Holger Kalthoff

   Pages 139-172

10. Minimal Residual Disease in Melanoma

    • Petra Goldin-Lang, Ulrich Keilholz

    Pages 173-183

11. Back Matter

    Pages 185-189

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Distant metastases are the main cause of cancer-related death. The onset of the metastatic process can now be assessed in cancer patients by the use of immunocytochemical and molecular methods that allow the identification of disseminated carcinoma cells in regional lymph nodes, peripheral blood or distant organs. There is increasing evidence that the detection and characterization of tumor cells present in bone marrow or peripheral blood can provide clinically important information.
In this book, leading experts in the area of micrometastasis research provide an overview that summarizes the current state of research on micrometastatic disease in patients with solid tumors. In each chapter, the technical aspect as well as clinical relevance of micrometastasis detection is discussed.
The book addresses basic researchers as well as clinicians involved in the treatment of cancer patients.

• DNA
• adjuvant therapy
• blood
• bone marrow
• carcinoma
• cell
• melanoma
• metastasis
• metastatic disease
• prostate cancer
• tumor

• Institute of Tumour Biology, University Hospital Hamburg-Eppendorf, Germany

  Klaus Pantel

 

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