Immunotoxins

1. Front Matter

   Pages i-xix

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2. Introduction

   1. Introduction

      • L. L. Houston

      Pages 1-7

3. Toxin Structure

   1. Front Matter

      Pages 9-9

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   2. Toxin structure

      • Jon D. Robertus

      Pages 11-24

   3. Structure—activity relationships in diphtheria toxin and Pseudomonas aeruginosa exotoxin A

      • R. John Collier

      Pages 25-35

4. How Toxins Work

   1. Front Matter

      Pages 37-37

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   2. How protein toxins enter and kill cells

      • Sjur Olsnes, Kirsten Sandvig

      Pages 39-73

   3. Mechanism of action of ricin and related toxins on the inactivation of eukaryotic ribosomes

      • Yaeta Endo

      Pages 75-89

5. Toxin Selection and Modification

   1. Front Matter

      Pages 91-91

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   2. Toxin selection and modification — Overview

      • R. J. Youle

      Pages 93-96

   3. Toxin selection and modification: Utilization of the A chain of ricin

      • F. K. Jansen, B. Bourrie, P. Casellas, D. Dussossoy, O. Gros, P. Vic et al.

      Pages 97-111

   4. Genetic engineering of immunotoxins

      • R. J. Youle, L. Greenfield, V. G. Johnson

      Pages 113-122

   5. Diphtheria-related peptide hormone gene fusions: A molecular genetic approach to chimeric toxin development

      • John R. Murphy

      Pages 123-140

   6. Immunotoxins containing ricin

      • Daniel A. Vallera, Dorothea E. Myers

      Pages 141-159

   7. Pseudomonas exotoxin — Immunotoxins

      • David J. FitzGerald, Mark C. Willingham, Ira Pastan

      Pages 161-173

   8. Immunotoxins containing single chain ribosome-inactivating proteins

      • John M. Lambert, Walter A. Blättler, Gordon D. McIntyre, Victor S. Goldmacher, Charles F. Scott Jr.

      Pages 175-209

6. Covalent Linking Agents

   1. Front Matter

      Pages 211-211

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   2. Antibody-toxin conjugation

      • Jon W. Marsh, Kasturi Srinivasachar, David M. Neville Jr.

      Pages 213-237

   3. Effect of chemical linkage upon the stability and cytotoxic activity of A chain immunotoxins

      • Edward J. Wawrzynczak, Philip E. Thorpe

      Pages 239-251

7. Antibody Selection

   1. Front Matter

      Pages 253-253

      PDF

Where do you begin to look for a recent, authoritative article on the diagnosis or management of a particular malignancy? The few general oncology textbooks are generally out of date. Single papers in specialized journals are informative but seldom comprehensive; these are more often preliminary reports on a very limited number of patients. Certain general journals frequently publish good indepth reviews of cancer topics, and published symposium lectures are often the best overviews available. Un­ fortunately, these reviews and supplements appear sporadically, and the reader can never be sure when a topic of special interest will be covered. Cancer Treatment and Research is a series of authoritative volumes which aim to meet this need. It is an attempt to establish a critical mass of oncology literature covering virtually all oncology topics, revised frequently to keep the coverage up-to-date, easily available on a single library shelf or by a single personal subscription. We have approached the problem in the following fashion. First, by dividing the oncology literature into specific subdivisions such as lung cancer, genitourinary cancer, pediatric oncology, etc. Second, by asking eminent authorities in each of these areas to edit a volume on the specific topic on an annual or biannual basis. Each topic and tumor type is covered in a volume appearing frequently and predictably, discussing current diagnosis, staging, markers, all forms of treatment modalities, basic biology, and more.

• Atmen
• Staging
• biology
• cancer treatment
• cell
• hormones
• leukemia
• liver
• prevention
• protein
• proteins
• transplantation
• tumor

• Department of Medicine Division of Hematology/Oncology, Duke University Medical Center, Durham, USA

  Arthur E. Frankel

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