Skip to main content
SpringerLink
Log in
Book cover

Platinum Coordination Complexes in Cancer Chemotherapy

Proceedings of the Fourth International Symposium on Platinum Coordination Complexes in Cancer Chemotherapy convened in Burlington, Vermont by the Vermont Regional Cancer Center and the Norris Cotton Cancer Center, June 22–24, 1983

  • Conference proceedings
  • © 1984

Overview

Editors:
  1. Miles P. Hacker

    1. Vermont Regional Cancer Center and Department of Pharmacology, University of Vermont, Burlington, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  2. Evan B. Douple
    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  3. Irwin H. Krakoff
    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Developments in Oncology (DION, volume 17)

This is a preview of subscription content, log in via an institution to check access.

Access this book

Log in via an institution
eBook USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

Licence this eBook for your library

Institutional subscriptions

Table of contents (28 papers)

  1. Front Matter

    Pages i-xiv
    Download chapter PDF

  2. Nomenclature

    1. Front Matter

      Pages 1-1
      Download chapter PDF

    2. Nomenclature for Platinum Antitumor Compounds

      • J. Reedijk
      Pages 3-8

  3. Biochemistry of Platinum Coordination Complexes in Cancer Chemotherapy

    1. Front Matter

      Pages 9-9
      Download chapter PDF

    2. Overview

      • S. J. Lippard
      Pages 11-13

    3. Chemical and Biological Studies of cis — Diamminedichloroplatinum (II) Binding to DNA

      • J. P. Caradonna, S. J. Lippard
      Pages 14-26

    4. Is DNA the Real Target of Antitumor Platinum Compounds?

      • J. P. Macquet, J. L. Butour, N. P. Johnson, H. Razaka, B. Salles, C. Vieussens et al.
      Pages 27-38

    5. Specific Binding of cis-Platinum Compounds to DNA and DNA Fragments

      • J. Reedijk, J. H. J. den Hartog, A. M. J. Fichtinger-Schepman, A. T. M. Marcelis
      Pages 39-63

  4. Pharmacology and Pharmacodynamics of Platinum Coordination Complexes in Cancer Chemotherapy

    1. Front Matter

      Pages 65-65
      Download chapter PDF

    2. Overview

      • C. L. Litterst
      Pages 67-70

    3. Plasma Pharmacokinetics, Urinary Excretion, and Tissue Distribution of Platinum Following IV Administration of Cyclobutanedicarboxylatoplatinum-II and cis-Platinum to Rabbits

      • C. L. Litterst
      Pages 71-81

    4. Clinical Pharmacokinetics of Diammine [1,1-Cydobutanedicarboxylato (2-)]-0,0′-Platinum (CBDCA)

      • P. V. Woolley, V. M. Priego, P. V. T. Luc, A. Rahman, P. S. Schein
      Pages 82-89

    5. Biliary Excretion, Renal Handling and Red Cell Uptake of Cisplatin and CBDCA in Animals

      • Z. H. Siddik, D. R. Newell, F. E. Boxall, M. Jones, K. G. McGhee, K. R. Harrap
      Pages 90-102

    6. Biodistribution and Pharmacokinetics of 195mPt-Labeled cis-Dichloro-trans-Dihydroxo-bis(Isopropylamine) Platinum (IV), CHIP, In the Normal Female Fischer 344 Rat

      • J. D. Hoeschele, L. A. Ferren, J. A. Roberts, L. R. Whitfield
      Pages 103-113

    7. Clinical Pharmacokinetics of cis-Dichloro-trans-Dihydroxy-bis(Isopropylamine)Platinum(IV)

      • L. Pendyala, J. W. Cowens, S. Madajewicz, P. J. Creaven
      Pages 114-125

    8. Disposition of Cisplatin vs Total Platinum in Animals and Man

      • L. A. Sternson, A. J. Repta, H. Shih, K. J. Himmelstein, T. F. Patton
      Pages 126-147

  5. Toxicology of Platinum Coordination Complexes in Cancer Chemotherapy

    1. Front Matter

      Pages 149-149
      Download chapter PDF

    2. Overview

      • M. P. Hacker
      Pages 151-153

    3. Diethyldithiocarbamate and cis-Platinum Toxicity

      • R. F. Borch, D. L. Bodenner, J. C. Katz
      Pages 154-164

    4. Selected Aspects of Cisplatin Nephrotoxicity in the Rat and Man

      • W. J. M. Hrushesky
      Pages 165-186
Back to top

Keywords

About this book

The idea for convening a Fourth International Symposium on Platinum Coordination Complexes in Cancer Chemotherapy was born in an assembly of researchers from the Vermont Regional Cancer Center and the Norris Cotton Cancer Center who shared a common interest in metal complexes. It was agreed by those assembled that sufficient time had passed since the Third International Symposium on Platinum Coor­ dination Complexes in Cancer Chemotherapy held in 1976 at the Wadley Institutes of Molecular Medicine in Dallas, Texas, during which several advances in the chemistry, biochemistry, pharmacology and clinical use of platinum complexes had occurred, to warrant a fourth symposium. Furthermore, intensive investigations in progress were bringing sophisticated methodologies to bear on the problems in the field, clinical trials were yielding interesting results, and unique approaches to cancer therapy were being designed. Therefore, an organizing committee was formed and planning culminated in the symposium which was held in Burlington, Vermont, June 22-24, 1983.

Editors and Affiliations

  • Vermont Regional Cancer Center and Department of Pharmacology, University of Vermont, Burlington, USA

    Miles P. Hacker

Bibliographic Information

  • Book Title: Platinum Coordination Complexes in Cancer Chemotherapy

  • Book Subtitle: Proceedings of the Fourth International Symposium on Platinum Coordination Complexes in Cancer Chemotherapy convened in Burlington, Vermont by the Vermont Regional Cancer Center and the Norris Cotton Cancer Center, June 22–24, 1983

  • Editors: Miles P. Hacker, Evan B. Douple, Irwin H. Krakoff

  • Series Title: Developments in Oncology

  • DOI: https://doi.org/10.1007/978-1-4613-2837-7

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Martinus Nijhoff Publishing, Boston 1984

  • Softcover ISBN: 978-1-4612-9792-5Published: 23 November 2011

  • eBook ISBN: 978-1-4613-2837-7Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: 408

  • Topics: Oncology

Publish with us

Policies and ethics

Back to top

Search

Navigation