MAP Kinase Signaling Protocols
Overview
- Editors:
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Rony Seger
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Department of Biological Regulation, The Zeizmann Institute of Science, Rehovot, Israel
Table of contents (21 protocols)
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- Hadara Rubinfeld, Rony Seger
Pages 1-28
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- Rafael Pulido, Ángel Zúñiga, Axel Ullrich
Pages 49-60
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- John M. Kyriakis, Hong Liu, Deborah N. Chadee
Pages 61-88
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- Richard I. Tapping, Kato Yutaka, Ta-Hsiang Chao, Masaaki Hayashi, Jeng-Fan Lo, Sung-Woo Kim et al.
Pages 89-96
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- Miranda van Triest, Johannes L. Bos
Pages 97-102
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- Josema Torres, Carmen Blanco-Aparicio, Rafael Pulido
Pages 103-112
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- Yoav D. Shaul, Rony Seger
Pages 113-125
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- Elizabeth J. Goldsmith, Melanie H. Cobb, Chung-I Chang
Pages 127-143
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- Makoto Adachi, Eisuke Nishida
Pages 145-153
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- Gilles Pagès, Jacques Pouysségur
Pages 155-166
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- Baltazar D. Aguda, Herbert M. Sauro
Pages 167-175
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- Bose S. Kochupurakkal, Yosef Yarden
Pages 177-202
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- Piero Crespo, J. Silvio Gutkind
Pages 203-210
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- Rikiro Fukunaga, Tony Hunter
Pages 211-236
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- Karine R. Bernard, Karen R. Jonscher, Katheryn A. Resing, Natalie G. Ahn
Pages 263-281
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- Andrew N. Hoofnagle, Katheryn A. Resing, Natalie G. Ahn
Pages 283-298
About this book
Mitogen-activated protein kinase (MAPK) signaling cascades are a group of protein kinases that play a central role in the intracellular transmission of extracellular signals. These cascades operate as major lines of communication within a complicated signaling network that regulates many cellular processes, including proliferation, differentiation, development, stress response, and apoptosis. More than 15,000 papers on MAPKs have been published over the past few years, with the number of publications increasing each year. More and more laboratories embark on the study of MAPK cascades in many d- tinct cellular systems and in particular their role in disease. Future challenges in the study of MAPK cascades remain in understa- ing the role of the various components and isoforms of the cascades in the multiple critical functions that they regulate in the whole organism, as well as the diseases caused by their malfunction. Data from gene-disrupted mice s- gest that inhibition of the MAPK cascades may have serious consequences on the development and growth of the animals. For example, targeted deletion of MEK1 is lethal, owing to developmental problems of placental vasculature and abnormal fibroblast migration. This lethality occurs in spite of the normal expression of MEK2, indicating that although the two MEK isoforms are apparently similar, they do have distinct functions, at least during embryog- esis. The ERK cascade was also shown to play a central role in brain function and in learning and memory.
Reviews
...this book continues the strong tradition of the series by recruiting the most prominent investigators in the field to provide a detailed discussion of specialized topics with a focus on direct practical applications.-Doody's Health Sciences Book Review Journal
Editors and Affiliations
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Department of Biological Regulation, The Zeizmann Institute of Science, Rehovot, Israel
Rony Seger
