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Textbook of Coronary Thrombosis and Thrombolysis

  • Book
  • © 1997

Overview

Editors:
  1. Richard C. Becker

    1. Cardiovascular Thrombosis Research Center, USA
      Coronary Care Unit, University of Massachusetts Medical School, Worcester

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Part of the book series: Developments in Cardiovascular Medicine (DICM, volume 193)

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Table of contents (46 chapters)

  1. Front Matter

    Pages i-xxi
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  2. Scientific Principles

    1. Front Matter

      Pages 1-1
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    2. The Biochemistry of Thrombosis

      1. Biochemistry of Intra Vascular Clotting: Focus on the Prothrombinase Complex
        • Frederick A. Spencer, Richard C. Becker
        Pages 5-13
      2. Plasma Coagulation Factors
        • Pamela Sakkinen, Russell P. Tracy
        Pages 15-28

    4. Fibrinolysis

      1. Molecular Regulation of Fibrinolysis
        • H. Roger Lijnen
        Pages 53-64
      2. Plasminogen Activator Inhibitor-1
        • Daniel T. Eitzman, William P. Fay, David Ginsburg
        Pages 65-78
      3. Biological Effects of Targeted Gene Inactivation and Gene Transfer of the Coagulation and Fibrinolytic Systems in Mice
        • Peter Carmeliet, Désiré Collen
        Pages 79-99
      4. Molecular Approaches to The Design of New Thrombolytic Agents
        • Bruce A. Keyt, Ted W. Love
        Pages 101-120

    5. Vascular Biology

      1. Endothelial Cell Biology
        • Una S. Ryan
        Pages 123-138
      2. Physiology of Vascular Homeostasis
        • Harsch Sanchorawala, John F. Keaney Jr.
        Pages 139-153
      3. Coronary Vascular Pharmacology
        • Marco N. Diaz, Richard A. Cohen
        Pages 155-168

    6. Experimental Models of Plaque Rupture, Thrombosis, and Thrombolysis

      1. Experimental Models of Coronary Arterial Resistance and Blood Flow
        • William P. Santamore
        Pages 171-182
      2. Pathogenesis of the Acute Coronary Syndromes: Hypotheses Generated from Clinical Experience
        • Narinder P. Bhalla, John A. Ambrose
        Pages 183-205
      3. Plaque Disruption and Thrombosis: Models to Evaluate Acute Cardiovascular Events
        • George S. Abela, Joel D. Eisenberg
        Pages 207-217
      4. Developing Antithrombotic and Thrombolytic Agents: The Role of Experimental Models
        • Richard C. Becker
        Pages 219-234

  3. Clinical Application of Scientific Principles

    1. Front Matter

      Pages 235-235
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    2. Thrombolytic Agents

      1. Streptokinase: Biochemistry and Phamacokinetics
        • H. Joost Kruik, Willemien J. Kollöffel, Freek W. A. Verheugt
        Pages 239-242
      2. Anistreplase (Anisoylated Plasminogen Streptokinase Activator Complex, Apsac) in Coronary Thrombolysis
        • David P. de Bono
        Pages 243-245
      3. Biochemistry, Pharmacokinetics, and Dynamics of Single- and Two- Chain Urokinase
        • Kurt Huber
        Pages 247-255
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Keywords

About this book

Teleologically, the hemostatic mechanism is among The of Coronary Thrombosis and the most fundamental yet complex physiologic pro- in essence, represents a heartfelt gift of cesses in humans. Early scientists and physicians were knowledge from a dedicated group of scientists and fascinated by the blood's ability to remain in a liquid clinicians, who collectively have set out on a mission state only to clot in response to vascular injury. The to minimize the societal impact of"hemostasis in the cellular and noncellular components of normal wrong place. " The book is divided into four distinct hemostasis took centuries to discover, and the intrica- sections: Part 1, Scientific Principles, lays down the cies of their delicate interactions are still being unrav- supporting foundation; Part 2, Clinical Application eled today. As is so often the case, an in-depth of Scientific Principles, places the knowledge base in appreciation of physiologic hemostasis, representing a a working perspective, directly applying science to basic life-sustaining sequence of events, paved the patient care; Part 3, New Dimensions, provides a way for understanding abnormal hemostasis or glimpse of tomorrow. Steering the field clear of se- pathologic thrombosis. Aristotle, Malpighi, and proclaimed victory and the dangers of complacency as Osier, representing but a few of the founding fathers we move into the 21st century, Part 4, Evolution of in the field, would undoubtedly be honored to see Thrombocardiology, focuses on laboratory standards, their observations form the template for lifesaving clinical trials, and drugs in development.

Editors and Affiliations

  • Cardiovascular Thrombosis Research Center, USA

    Richard C. Becker

  • Coronary Care Unit, University of Massachusetts Medical School, Worcester

    Richard C. Becker

Bibliographic Information

  • Book Title: Textbook of Coronary Thrombosis and Thrombolysis

  • Editors: Richard C. Becker

  • Series Title: Developments in Cardiovascular Medicine

  • DOI: https://doi.org/10.1007/b102433

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1997

  • Hardcover ISBN: 978-0-7923-9923-0Published: 31 January 1998

  • Softcover ISBN: 978-1-4757-7078-0Published: 20 April 2013

  • eBook ISBN: 978-0-585-33754-8Published: 21 January 2008

  • Series ISSN: 0166-9842

  • Edition Number: 1

  • Number of Pages: XXI, 679

  • Number of Illustrations: 57 b/w illustrations, 4 illustrations in colour

  • Topics: Cardiology, Hematology

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