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A Molecular and Cellular View of Protein Kinase CK2

  • Book
  • © 1999

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Editors:
  1. Khalil Ahmed

    1. Cellular and Molecular Biochemistry, Research Laboratory (151) V.A. Medical Centre, Minneapolis, USA

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  2. O. G. Issinger

    1. Biokemisk Institut, Odense Universitet, Odense M, Denmark

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  3. E. Chambaz

    1. Laboratoire de Biochemie des Regulations Cellulaires Endocrines, INSERM U244 DBMS, CEA Grenoble, Grenoble Cedex 9, France

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Part of the book series: Developments in Molecular and Cellular Biochemistry (DMCB, volume 27)

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Table of contents (28 chapters)

  1. Front Matter

    Pages i-2
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  2. CK2, a protein kinase of the next millennium

    • Grazyna Dobrowolska, Fred J. Lozeman, Dongxia Li, Edwin G. Krebs
    Pages 3-12

  3. A multifunctional network of basic residues confers unique properties to protein kinase CK2

    • Stefania Sarno, Philippe Vaglio, Luca Cesaro, Oriano Marin, Lorenzo A. Pinna
    Pages 13-19

  4. Intermolecular contact sites in protein kinase CK2

    • Andreas Krehan, Walter Pyerin
    Pages 21-28

  5. Binding of polylysine to protein kinase CK2, measured by Surface Plasmon Resonance

    • Maria J. Benitez, Gerardo Mier, Fernando Brione, Francisco J. Moreno, Juan S. Jiménez
    Pages 29-33

  6. Functional analysis of CK2β-derived synthetic fragments

    • Flavio Meggio, Oriano Marin, Stefania Sarno, Lorenzo A. Pinna
    Pages 35-42

  7. Dissecting subdomains involved in multiple functions of the CK2β subunit

    • Didier Leroy, Odile Filhol, Nora Quintaine, Denis Sarrouilhe, Petra Loue-Mackenbach, Edmond M. Chambaz et al.
    Pages 43-50

  8. Interactions of protein kinase CK2β subunit within the holoenzyme and with other proteins

    • Mette Kusk, Rehana Ahmed, Bo Thomsen, Christian Bendixen, Olaf-Georg Issinger, Brigitte Boldyreff
    Pages 51-58

  9. CK2α loci in the human genome: Structure and transcriptional activity

    • Ute Wirkner, Walter Pyerin
    Pages 59-64

  10. Murine protein kinase CK2: Gene and oncogene

    • Xin Xu, Esther Landesman-Bollag, Padma L. Channavajhala, David C. Seldin
    Pages 65-74

  11. Interactions of protein kinase CK2 subunits

    • Iris Korn, Silvio Gutkind, N. Srinivasan, Tom L. Blundell, Catherine C. Allende, Jorge E. Allende
    Pages 75-83

  12. Mutations in the C-terminal domain of topoisomerase II affect meiotic function and interaction with the casein kinase 2 β subunit

    • D. Leroy, G. C. Alghisi, E. Roberts, O. Filhol-Cochet, S. M. Gasser
    Pages 85-95

  13. Association of protein kinase CK2 with eukaryotic translation initiation factor eIF-2 and with grp94/endoplasmin

    • Marta Riera, Nerea Roher, Francesc Miró, Carles Gil, Ramon Trujillo, José Aguilera et al.
    Pages 97-104

  14. Searching interaction partners of protein kinase CK2β subunit by two-hybrid screening

    • Swen Grein, Karine Raymond, Claude Cochet, Walter Pyerin, Edmond M. Chambaz, Odile Filhol
    Pages 105-109

  15. Protein kinase CK2 interacts with a multi-protein binding domain of p53

    • Claudia Götz, Petra Scholtes, Alexandra Prowald, Norbert Schuster, Wolfgang Nastainczyk, Mathias Montenarh
    Pages 111-120

  16. BTF3 is a potential new substrate of protein kinase CK2

    • Swen Grein, Walter Pyerin
    Pages 121-128

  17. Protein kinase CK2α may induce gene expression but unlikely acts directly as a DNA-binding transcription-activating factor

    • Karin Ackermann, Walter Pyerin
    Pages 129-134

  18. Role of protein kinase CK2 in phosphorylation of nucleosomal proteins in relation to transcriptional activity

    • Chuanhai Guo, Alan T. Davis, Shihui Yu, Sherif Tawfic, Khalil Ahmed
    Pages 135-142

  19. A review of progress towards elucidating the role of protein kinase CK2 in polymerase III transcription: Regulation of the TATA binding protein

    • Ataollah Ghavidel, Darren J. Hockman, Michael C. Schultz
    Pages 143-148

  20. The binding of the α subunit of protein kinase CK2 and RAP74 subunit of TFIIF to protein-coding genes in living cells is DRB sensitive

    • E. Egyházi, A. Ossoinak, O. Filhol-Cochet, C. Cochet, A. Pigon
    Pages 149-159
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Keywords

About this book

It is now generally recognized that protein kinase signaling is involved in virtually every aspect of cell function, including growth and proliferation. The field of protein phosphorylation, including the enzymes involved in this post-translational modification, continues to advance at a fascinating pace.
Since the first international meeting on this topic, held in Heidelberg in 1994, several new avenues of CK2 research have emerged despite persistent deficiencies in our understanding of the regulation of its activity. Among the significant new directions are studies related to the structure of the enzyme, especially its crystal structure, as well as an interesting aspect of CK2 function that involves its subunits as binding partners of several other proteins. In addition, new data have been gathered on the role of CK2 in transcription as well as in certain other cellular functions. To address these various aspects of the progress of CK2, a number of key scientists from different parts of the world came together at the second international meeting on `A Molecular and Cellular View of Protein Kinase CK2', held at Villard de Lans near Grenoble on September 24-26, 1997. The meeting was attended by nearly 50 participants and included 28 presentations, which provide a view of the latest progress on protein kinase CK2.

Editors and Affiliations

  • Cellular and Molecular Biochemistry, Research Laboratory (151) V.A. Medical Centre, Minneapolis, USA

    Khalil Ahmed

  • Biokemisk Institut, Odense Universitet, Odense M, Denmark

    O. G. Issinger

  • Laboratoire de Biochemie des Regulations Cellulaires Endocrines, INSERM U244 DBMS, CEA Grenoble, Grenoble Cedex 9, France

    E. Chambaz

Bibliographic Information

  • Book Title: A Molecular and Cellular View of Protein Kinase CK2

  • Editors: Khalil Ahmed, O. G. Issinger, E. Chambaz

  • Series Title: Developments in Molecular and Cellular Biochemistry

  • DOI: https://doi.org/10.1007/978-1-4419-8624-5

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1999

  • Hardcover ISBN: 978-0-7923-8208-9Published: 28 February 1999

  • Softcover ISBN: 978-1-4613-4648-7Published: 13 September 2012

  • eBook ISBN: 978-1-4419-8624-5Published: 18 September 2012

  • Edition Number: 1

  • Number of Pages: V, 239

  • Topics: Biochemistry, general

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