New Directions in Affective Disorders

Pathogenesis of Affective Disorders and Basic Mechanisms of Drug Action

1. Front Matter

   Pages 1-1

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2. Animal Models and Antidepressant Predictability

   1. Neurochemical and Behavioral Effects of Stress: A Rat Model of Depression

      • G. Curzon, D. J. Haleem, G. A. Kennett

      Pages 5-8

   2. Study of Olfactory Bulbectomized Rats: Revelations About Major Depressive Disorder

      • J. Steven Richardson

      Pages 9-12

   3. Bilaterally Olfactory Bulbectomized Rat Model of Depression

      • B. E. Leonard, J. Butler, B. O’Neill, W. T. O’Connor

      Pages 13-16

   4. Behavioral Despair: Past and Future

      • Roger D. Porsolt

      Pages 17-20

   5. Genetically Nervous and Normal Pointer Dogs: Relation Between Hearing and Behavioral Abnormalities

      • Ehud Klein, Thomas W. Uhde

      Pages 21-24

   6. Agonist-Induced Down-Regulation of β1-Adrenergic Receptors: Possible Biochemical Rationale for Novel Antidepressants

      • S. M. Stahl

      Pages 25-28

   7. Behavioral Pharmacology and Clinical Antidepressant Effects of β-Adrenergic Agonists

      • H. Frances, P. Simon, Y. Lecrubier, D. Widlöcher

      Pages 29-32

3. Monoamines and Neuropeptides

   1. Beyond Nosology in Biological Psychiatry: Prolegomena of a Functional Psychopathology

      • Herman M. van Praag

      Pages 35-39

   2. Serotonergic Aspects of Agonistic Behavior

      • Berend Olivier, Jan Mos

      Pages 40-44

   3. Noradrenergic and Serotonergic Dysfunction in the Affective Disorders

      • Larry J. Siever, Emil F. Coccaro, Richard Friedman, Karen Rubinstein, Kenneth L. Davis

      Pages 45-48

   4. Neuropeptides and Affective Disorders

      • Jan M. Van Ree, David De Wied

      Pages 49-53

   5. Antemortem and Postmortem Measures of Central Nervous System Serotonergic Function: Methodological Issues

      • Michael Stanley, Ronald M. Winchel

      Pages 54-59

   6. Postmortem Investigation of Serotonergic and Peptidergic Hypotheses of Affective Illness

      • I. N. Ferrier, I. G. McKeith, B. G. Charlton, C. A. Whitford, E. Marshall, R. H. Perry et al.

      Pages 60-63

4. Cholinergic Mechanisms

   1. Genetic Animal Model of Depression with Cholinergic Supersensitivity

      • David H. Overstreet

      Pages 67-70

   2. Impact of the Cholinergic System on the Hypothalamic-Pituitary-Adrenocortical Axis and on REM Sleep

      • J-C. Krieg, M. Berger

      Pages 71-74

   3. Relation Between <i>m</i>-Cholinoceptor Density on Human Blood Cells and Psychological Predisposition Factors for Depression

      • Walter E. Müller, Birgit Bering, Hans W. Moises

      Pages 75-78

   4. Differential Effects of Physostigmine in Alcoholics, Alcoholics with Affective Disorder, and Normal Individuals

      • David S. Janowsky, S. Craig Risch

      Pages 79-81

5. Basic Mechanisms of Antidepressants and Anxiolytics

   1. Serotonin/Norepinephrine/Steroid Receptor Link in Brain and the Mode of Action of Antidepressants: Update and New Perspectives

      • Fridolin Sulser, Elaine Sanders-Bush

      Pages 85-88