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Principles of Clinical Cancer Genetics

A Handbook from the Massachusetts General Hospital

  • Book
  • © 2010

Overview

Editors:
  1. Daniel C. Chung

    1. Cancer Center and Gastrointestinal Unit, Harvard Medical School, Massachusetts General Hospital, Boston, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Daniel A. Haber

    1. Cancer Center, Harvard Medical School and, Massachusetts General Hospital, Boston, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Designed for professionals in medical genetics, medical oncology, surgical oncology, and genetic counseling, each chapter emphasizes the practical, clinical aspects of integrating genetics into cancer care

  • Includes supplementary material: sn.pub/extras

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Table of contents (15 chapters)

  1. Front Matter

    Pages i-xi
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  2. Basic Principles of Cancer Genetics

    • Leif W. Ellisen, Daniel A. Haber
    Pages 1-22

  3. Principles of Cancer Genetic Counseling and Genetic Testing

    • Kristen M. Shannon, Devanshi Patel
    Pages 23-40

  4. Genetics of Hereditary Breast Cancer

    • Paula D. Ryan
    Pages 41-51

  5. Surgical Management of Hereditary Breast and Ovarian Cancer

    • Michelle C. Specht, Marcela G. del Carmen, Barbara L. Smith
    Pages 53-62

  6. Hereditary Colon Cancer: Colonic Polyposis Syndromes

    • Andrew T. Chan, Daniel C. Chung
    Pages 63-76

  7. Hereditary Colon Cancer: Lynch Syndrome

    • Eunice L. Kwak, Daniel C. Chung
    Pages 77-88

  8. Hereditary Pancreatic Cancer

    • Janivette Alsina, Sarah P. Thayer
    Pages 89-96

  9. Hereditary Diffuse Gastric Cancer

    • Prakash K. Pandalai, Sam S. Yoon
    Pages 97-107

  10. Familial Renal Cell Cancers and Pheochromocytomas

    • Gayun Chan-Smutko, Othon Iliopoulos
    Pages 109-128

  11. Familial Atypical Mole Melanoma (FAMM) Syndrome

    • Elizabeth D. Chao, Michele J. Gabree, Hensin Tsao
    Pages 129-144

  12. Multiple Endocrine Neoplasia

    • Yariv J. Houvras, Gilbert H. Daniels
    Pages 145-162

  13. Pediatric Malignancies: Retinoblastoma and Wilms’ Tumor

    • David A. Sweetser, Eric F. Grabowski
    Pages 163-180

  14. Neurofibromatosis and Schwannomatosis

    • Miriam J. Smith, Scott R. Plotkin
    Pages 181-193

  15. The HapMap Project and Low-Penetrance Cancer Susceptibility Alleles

    • Edwin Choy, David Altshuler
    Pages 195-204

  16. Somatic Genetic Alterations and Implications for Targeted Therapies in Cancer (GIST, CML, Lung Cancer)

    • Alice T. Shaw, Eyal C. Attar, Edwin Choy, Jeffrey Engelman
    Pages 205-220

  17. Back Matter

    Pages 221-227
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Keywords

About this book

Advances in genetics are transforming estimates of an individual’s risk of developing cancer and approaches to prevention and management of cancer in those who may have increased susceptibility. Identifying and caring for patients with hereditary cancer syndromes and their family members present a complex clinical, scientific and social challenge. This textbook, by leading experts at Massachusetts General Hospital Cancer Center, highlights the current understanding of the genetics of hereditary cancers of the breast, ovary, colorectum, stomach, pancreas, kidney, skin, and endocrine organs. Practical guidelines for the use of genetic testing, cancer screening and surveillance, prophylactic surgery, and promising targeted therapeutic agents are discussed.

In addition, ongoing research involving genome-wide screens to identify novel modest risk-associated genetic loci are explored, along with new approaches to the application of genetic markers in guiding therapeutic options.

Reviews

From the reviews:

“This thorough book outlines the most common genetic contributions to cancer and reviews cancer genetics and genetic counseling as well as recent advances in genome-wide association studies (GWAS) research and personalized medicine. … a largely useful resource, particularly for students, residents, and entry-level clinicians in clinical cancer genetics.” (Heather H. Wetzel, Doody’s Review Service, August, 2010)

Editors and Affiliations

  • Cancer Center and Gastrointestinal Unit, Harvard Medical School, Massachusetts General Hospital, Boston, USA

    Daniel C. Chung

  • Cancer Center, Harvard Medical School and, Massachusetts General Hospital, Boston, USA

    Daniel A. Haber

Bibliographic Information

  • Book Title: Principles of Clinical Cancer Genetics

  • Book Subtitle: A Handbook from the Massachusetts General Hospital

  • Editors: Daniel C. Chung, Daniel A. Haber

  • DOI: https://doi.org/10.1007/978-0-387-93846-2

  • Publisher: Springer New York, NY

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer Science+Business Media, LLC 2010

  • Hardcover ISBN: 978-0-387-93844-8Published: 14 May 2010

  • Softcover ISBN: 978-1-4899-7785-4Published: 23 August 2016

  • eBook ISBN: 978-0-387-93846-2Published: 20 July 2010

  • Edition Number: 1

  • Number of Pages: XI, 227

  • Topics: Oncology, Human Genetics

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