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Tropomyosin

  • Book
  • © 2008

Overview

Editors:
  1. Peter Gunning

    1. Oncology Research Unit, Department of Pharmacology School of Medical Sciences, University of New South Wales, Sydney, Australia

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Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 644)

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Table of contents (22 chapters)

  1. Front Matter

    Pages i-xix
    Download chapter PDF

  2. Introduction and Historical Perspective

    1. Introduction and Historical Perspective

      • Peter Gunning
      Pages 1-5

  3. Genes and Their Expression

    1. Structure and Evolution of Tropomyosin Genes

      • Bernadette Vrhovski, Nadine Thézé, Pierre Thiébaud
      Pages 6-26

    2. Tropomyosin Exons as Models for Alternative Splicing

      • Clare Gooding, Christopher W. J. Smith
      Pages 27-42

    3. Tropomyosin Gene Expression in Vivo and in Vitro

      • Galina Schevzov, Geraldine O’Neill
      Pages 43-59

  4. Protein Structure

    1. Tropomyosin: Function Follows Structure

      • Sarah E. Hitchcock-DeGregori
      Pages 60-72

    2. Dimerization of Tropomyosins

      • Mario Gimona
      Pages 73-84

  5. Role in Muscle Function

    1. Cooperative Binding of Tropomyosin to Actin

      • Larry S. Tobacman
      Pages 85-94

    2. Tropomyosin and the Steric Mechanism of Muscle Regulation

      • William Lehman, Roger Craig
      Pages 95-109

    3. Role of Tropomyosin in the Regulation of Contraction in Smooth Muscle

      • Steve Marston, M. El-Mezgueldi
      Pages 110-123

  6. Tropomyosin in Human Disease

    1. Tropomyosin as a Regulator of Cancer Cell Transformation

      • David M. Helfman, Patrick Flynn, Protiti Khan, Ali Saeed
      Pages 124-131

    2. The Role of Tropomyosin in Heart Disease

      • David F. Wieczorek, Ganapathy Jagatheesan, Sudarsan Rajan
      Pages 132-142

    3. Tropomyosins in Skeletal Muscle Diseases

      • Anthony J. Kee, Edna C. Hardeman
      Pages 143-157

    4. Tropomyosins in Human Diseases: Ulcerative Colitis

      • Kiron M. Das, Manisha Bajpai
      Pages 158-167

  7. Tropomyosin Directed Regulation of the Cytoskeleton

    1. Tropomyosin Function in Yeast

      • David Pruyne
      Pages 168-186

    2. Isoform Sorting of Tropomyosins

      • Claire Martin, Peter Gunning
      Pages 187-200

    3. Human Tropomyosin Isoforms in the Regulation of Cytoskeleton Functions

      • Jim Jung-Ching Lin, Robbin D. Eppinga, Kerri S. Warren, Keith R. McCrae
      Pages 201-222

  8. Mechanisms of Tropomyosin Function

    1. Tropomyosins Regulate the Impact of Actin Binding Proteins on Actin Filaments

      • Uno Lindberg, Clarence E. Schutt, Robert D. Goldman, Maria Nyåkern-Meazza, Louise Hillberg, Li-Sophie Zhao Rathje et al.
      Pages 223-231

    2. Tropomyosin and ADF/Cofilin as Collaborators and Competitors

      • Thomas B. Kuhn, James R. Bamburg
      Pages 232-249

    3. Caldesmon and the Regulation of Cytoskeletal Functions

      • C. -L. Albert Wang
      Pages 250-272
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Keywords

About this book

A recent review of one of my grant applications commented on the ‘rediscovery of tropomyosin’. I was tempted to write back in my rebuttal to the reviewer that I didn’t realise it had been lost. Uncharacteristic maturity prevailed and I resisted the temptation, but I was struck by the underlying observation that research on the str- ture and function of tropomyosin has been somewhat invisible, particularly in terms of the cytoskeleton isoforms. So, how can it be that one of the two major components of the actin filament has been so thoroughly overlooked? I suspect that the answer is disappointingly pedestrian. Whereas the biochemistry of the 1980s revealed the potential of tropomyosin isoforms to diversify the function of actin filaments, the subsequent disenchantment with isoform biology in general in the 1990s inhibited growth of this field. With the development of more sophisticated experimental - proaches we are now seeing a growing realisation of the importance of tropomyosin in regulating actin filaments beyond its pivotal role in muscle contraction. The opportunity to edit this book came at a time when we had written several reviews on different aspects of tropomyosin function and I had just finished the background reading for a comprehensive review of tropomyosin biology. I realised that the field was simply beyond the capacity of any one person to do the field j- tice.

Editors and Affiliations

  • Oncology Research Unit, Department of Pharmacology School of Medical Sciences, University of New South Wales, Sydney, Australia

    Peter Gunning

About the editor

PETER GUNNING, PhD, is Head of the Oncology Research Unit, Department of Pharmacology, School of Medical Sciences, at the University of New South Wales located in Sydney, Australia. The primary focus of his research is the regulation of cell and tissue architecture and its modification in cancer. He is a member of numerous professional organisations and has served on the Boards of the NSW Cancer Council and Bio-Link Partners and as Chairman of the NSW Cancer Council and NSW Cancer Institute Research Committees. Peter received his academic degrees from Monash University, Melbourne, Australia.

Bibliographic Information

  • Book Title: Tropomyosin

  • Editors: Peter Gunning

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-0-387-85766-4

  • Publisher: Springer New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 2008

  • Hardcover ISBN: 978-0-387-85765-7Published: 06 November 2008

  • Softcover ISBN: 978-1-4419-2760-6Published: 06 December 2010

  • eBook ISBN: 978-0-387-85766-4Published: 30 September 2009

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: XIX, 304

  • Number of Illustrations: 80 b/w illustrations, 8 illustrations in colour

  • Topics: Biomedicine general

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