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Mitochondria and Cancer

  • Book
  • © 2009

Overview

Editors:
  1. Leslie Costello
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    You can also search for this editor in PubMed   Google Scholar

  2. Keshav Singh
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    You can also search for this editor in PubMed   Google Scholar

  • Aims to provide a comprehensive analysis of the role mitochondria play in carcinogenesis
  • Will also provide up to date mitochondrial therapeutic approaches for treatment of cancer

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Table of contents (14 chapters)

  1. Front Matter

    Pages i-xii
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  2. Mitochondria and Cancer

    • Kjerstin M. Owens, J. S. Modica-Napolitano, Keshav K. Singh
    Pages 1-21

  3. Warburg and his Legacy

    • Michael Ristow, Tim J. Schulz
    Pages 23-38

  4. The Lipogenic Switch in Cancer

    • Koen Brusselmans, Johannes V. Swinnen
    Pages 39-59

  5. Citrate Metabolism in Prostate and Other Cancers

    • Renty B. Franklin, Leslie C. Costello
    Pages 61-78

  6. Integration of Genetic, Proteomic, and Metabolic Approaches in Tumor Cell Metabolism

    • Leslie C. Costello, Renty B. Franklin
    Pages 79-92

  7. Mitochondrial Respiration and Differentiation

    • Roberto Scatena, Patrizia Bottoni, Bruno Giardina
    Pages 93-102

  8. Integration of Energy Metabolism and Control of Apoptosis in Tumor Cells

    • John G. Pastorino, Jan B. Hoek
    Pages 103-129

  9. Energy Generating Pathways and the Tumor Suppressor p53

    • Chad A. Corcoran, Ying Huang, M. Saeed Sheikh
    Pages 131-150

  10. Mitochondrial Tumor Suppressors

    • Bora E. Baysal
    Pages 151-162

  11. Mitochondria in Hematology

    • Stefanie Zanssen
    Pages 163-191

  12. Mitochondria and Oncocytomas

    • J. Lima, V. Máximo, P. Soares, R. Portugal, S. Guimarães, M. Sobrinho-Simões
    Pages 193-209

  13. Mitochondria as Targets for Cancer Therapy

    • Stephen J. Ralph, Jiri Neuzil
    Pages 211-249

  14. Reversing the Warburg Effect: Metabolic Modulation as a Novel Cancer Therapy

    • Gopinath Sutendra, Evangelos D. Michelakis
    Pages 251-264

  15. Mitochondrial Nanotechnology for Cancer Therapy

    • Volkmar Weissig, Gerard G. M. D’Souza, Shing-Ming Cheng, Sarathi Boddapati
    Pages 265-279

  16. Back Matter

    Pages 281-289
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Keywords

About this book

Nearly a century of scientific research has revealed that mitochondrial dysfunction is one of the most common and consistent phenotypes of cancer cells. A number of notable differences in the mitochondria of normal and cancer cells have been described. These include differences in mitochondrial metabolic activity, molecular composition of mitochondria and mtDNA sequence, as well as in alteration of nuclear genes encoding mitochondrial proteins. This book, Mitochondria and Cancer, edited by Keshav K. Singh and Leslie C. Costello, presents thorough analyses of mitochondrial dysfunction as one of the hallmarks of cancer, discusses the clinical implications of mitochondrial defects in cancer, and as unique cellular targets for novel and selective anti-cancer therapy.

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