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Cyclin Dependent Kinase 5 (Cdk5)

  • Book
  • © 2008

Overview

Editors:
  1. Li-Huei Tsai
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    You can also search for this editor in PubMed   Google Scholar

  2. Nancy Y. Ip
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  • Will appeal to researchers from various fields of neuroscience research, in light of the extensive involvement of Cdk5 in neuronal development, plasticity and neurological disorders

  • Written by leaders in the field of Cdk5 research

  • Will encompass a variety of Cdk5 studies using different approaches to elucidate the functions and signaling mechanisms of Cdk5

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Table of contents (18 chapters)

  1. Front Matter

    Pages i-xvi
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  2. Cdk5/p35 Regulates Neuronal Migration

    • Toshio Ohshima
    Pages 1-8

  3. CRMP Family Protein: Novel Targets for Cdk5 That Regulates Axon Guidance, Synapse Maturation, and Cell Migration

    • Yoshio Goshima, Yukio Sasaki, Yutaka Uchida, Naoya Yamashita, Fumio Nakamura
    Pages 9-24

  4. Cdk5 in Presynapses

    • Fan-Yan Wei, Kazuhito Tomizawa
    Pages 25-33

  5. Cyclin-Dependent Kinase 5: A Critical Regulator of Neurotransmitter Release

    • Sul-Hee Chung
    Pages 35-50

  6. Cdk5 in Dendrite and Synapse Development: Emerging Role as a Modulator of Receptor Tyrosine Kinase Signaling

    • Zelda H. Cheung, Nancy Y. Ip
    Pages 51-68

  7. Cyclin-Dependent Kinase 5 (Cdk5) Modulates Signal Transduction Pathways Regulating Neuronal Survival

    • Parvathi Rudrabhatla, Jyotshna Kanungo, Ya-Li Zheng, Niranjana D. Amin, Sashi Kesavapany, Harish C. Pant
    Pages 69-90

  8. CDK5 and Mitochondrial Cell Death Pathways

    • Katrin Meuer, Mathias Bähr, Jochen H. Weishaupt
    Pages 91-106

  9. Regulation and Function of Cdk5 in the Nucleus

    • Qian Yang, Zixu Mao
    Pages 107-118

  10. Cdk5 May Be an Atypical Kinase, but Not in the Way You Think

    • Li Wang, Jie Zhang, Karl Herrup
    Pages 119-137

  11. Cdk5 and Neuregulin-1 Signaling

    • Yi Wen, Haung Yu, Karen Duff
    Pages 139-144

  12. Cyclin-Dependent Kinase 5 and Insulin Secretion

    • Christina Bark, Marjan Rupnik, Marko Jevsek, Slavena A. Mandic, Per-Olof Berggren
    Pages 145-158

  13. Protein–Protein Interactions Involving the N-Terminus of p35

    • Gary Kar Ho Ng, Lisheng He, Robert Z. Qi
    Pages 159-170

  14. The Kinase Activity of Cdk5 and Its Regulation

    • Shin-ichi Hisanaga, Koichi Ishiguro
    Pages 171-190

  15. The Structural Bases of CDK5 Activity

    • Andrea Musacchio
    Pages 191-210

  16. Cdk5, a Journey from Brain to Pain: Lessons from Gene Targeting

    • Tej K. Pareek, Ashok B. Kulkarni
    Pages 211-226

  17. Involvement of Cdk5 in Synaptic Plasticity, and Learning and Memory

    • Florian Plattner, K. Peter Giese, Marco Angelo
    Pages 227-260

  18. Cyclin-Dependent Kinase 5 (Cdk5): Linking Synaptic Plasticity and Neurodegeneration

    • Andre Fischer, Li-Huei Tsai
    Pages 261-282

  19. Cdk5 as a Drug Target for Alzheimer’s Disease

    • Lit-Fui Lau, Carol D. Hicks
    Pages 283-299

  20. Back Matter

    Pages 301-329
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Keywords

About this book

Cyclin Dependent Kinase 5 provides a comprehensive and up-to-date collection of reviews on the discovery, signaling mechanisms and functions of Cdk5, as well as the potential implication of Cdk5 in the treatment of neurodegenerative diseases. Since the identification of this unique member of the Cdk family, Cdk5 has emerged as one of the most important signal transduction mediators in the development, maintenance and fine-tuning of neuronal functions and networking. Further studies have revealed that Cdk5 is also associated with the regulation of neuronal survival during both developmental stages and in neurodegenerative diseases. These observations indicate that precise control of Cdk5 is essential for the regulation of neuronal survival. The pivotal role Cdk5 appears to play in both the regulation of neuronal survival and synaptic functions thus raises the interesting possibility that Cdk5 inhibitors may serve as therapeutic treatment for a number of neurodegenerative diseases.

Bibliographic Information

  • Book Title: Cyclin Dependent Kinase 5 (Cdk5)

  • Editors: Li-Huei Tsai, Nancy Y. Ip

  • DOI: https://doi.org/10.1007/978-0-387-78887-6

  • Publisher: Springer New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer-Verlag US 2008

  • Hardcover ISBN: 978-0-387-78886-9Published: 19 August 2008

  • Softcover ISBN: 978-1-4899-8774-7Published: 12 September 2014

  • eBook ISBN: 978-0-387-78887-6Published: 28 February 2009

  • Edition Number: 1

  • Number of Pages: XVI, 313

  • Topics: Neurosciences, Cell Biology, Developmental Biology

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