Axon Growth and Guidance

1. Front Matter

   Pages i-xvi

   PDF

2. Molecular Mechanisms of Axonal Growth

   • Céline Bouquet, Fatiha Nothias

   Pages 1-16

3. Netrins and Their receptors

   • Simon W. Moore, Marc Tessier-Lavigne, Timothy E. Kennedy

   Pages 17-31

4. Eph Receptors and Ephrin Ligands in Axon Guidance

   • Michael Reber, Robert Hindges, Greg Lemke

   Pages 32-49

5. Role of Semaphorins during Axon Growth and Guidance

   • Eric Koncina, Lise Roth, Bertand Gonthier, Dominique Bagnard

   Pages 50-64

6. Slits and Their Receptors

   • Alain Chédotal

   Pages 65-80

7. Neurotrophic Factors: Are They Axon Guidance Molecules?

   • Sarah Guthrie

   Pages 81-94

8. The Role of Cell Adhesion Molecules in Axon Growth and Guidance

   • Hiroyuki Kamiguchi

   Pages 95-102

9. Neurotransmitters and the Development of Neuronal Circuits

   • Tina Ruediger, Juergen Bolz

   Pages 104-114

10. The Hedgehog, TGF-β/BMP and Wnt Families of Morphogens in Axon Guidance

    • Frédéric Charron, Marc Tessier-Lavigne

    Pages 116-133

11. The Role of Cyclic Nucleotides in Axon Guidance

    • Michael Piper, Francis van Horck, Christine Holt

    Pages 134-143

12. Membrane Lipid Rafts and Their Role in Axon Guidance

    • Carmine Guirland, James Q. Zheng

    Pages 144-154

13. The Role of Glial Cells in Axon Guidance, Fasciculation and Targeting

    • Anabel R. Learte, Alicia Hidalgo

    Pages 156-166

14. Back Matter

    Pages 167-169

    PDF

The complexarchitectureofneuronal networks togetherwith the extraordinary associated functions make the nervous system a fascinating biological structure. The considerable work performed to explore this cellular machinery is nowadays successfulbecause the mysteryofnervous system developmentisbeing unravelled. As described in their outstanding review published 10 years ago in Science.' Marc Tessier-Lavigne and Corey Goodman-the pioneers of the molecular era of axon guidance-summarized the assembly of nervous system connections as a subtle game of attraction and repulsion of neuronal growth cones. The cellular ballet ensuring the formation of billions of synapses, which ultimately gives rise to the highest cognitive functions, is primarily orchestrated by a step-by-step mechanism of growth driven by multiple molecular cues. While our general concept of axon guidance remains identical, a profound evolution ofour knowledge ofthe molecular identityofthe guidance cues together with their interactions and signalling pathways occurred over the past ten years. This book proposes an exhaustive and updated view ofthe current knowledge ofthe molecular and cellular mechanisms ensuring axon growth and guidance. An introductory chapterby C. Bouquetand F.Nothias will remind the readers ofall the features ofa growth cone and the mechanisms controlling its growth. From there, one enters a fabulous journey with a growth cone, a Tom Thumb story filled with molecular encounters and complex interactions leading to one ofthe most fantastic developmental achievements: the nervous system wiring.

• Nervous System
• axon
• cell
• lipide
• membrane
• neurotransmitter
• receptor
• research

• Laboratoire de Neurobiologie du Developpement et de la Regeneration (LNDR), Centre de Neurochimie de CNRS, Strasbourg, France

  Dominique Bagnard

Policies and ethics