Peptides for Youth

1. Front Matter

   Pages i-ciii

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2. Library Generation Analysis and Combinatorial Chemistry: dedicated to Bruce Merrifield

   1. Dynamic Combinatorial Assembly of Peptide-Rhenium Coordinates: Application to the Selection of hCyp-18 inhibitors from a Library of 12 × 16 Components

      • C. Dugave, C. Clavaud, J. Le Gal, R. Thai, M. Moutiez

      Pages 3-4

   2. Dynamic Combinatorial Assembly of Peptide-Rhenium Coordinates: Coordination Chemistry for Generating New Analogs of hCyp-18 Ligands

      • C. Clavaud, J. Le Gal, R. Thai, M. Moutiez, C. Dugave

      Pages 5-6

   3. Oxorhenium-Mediated Cyclization and Self-Assembly of Peptides: A Combinatorial Approach for the Selection of New Ligands of the Human Cyclophilin hCyp-18

      • C. Clavaud, M. Heckenroth, C. Stricane, M-A. Lelait, A. Ménez, C. Dugave

      Pages 7-8

   4. Thieno[3,2-e]diazepinediones and 3-Thienylimidazolidinediones Syntheses: Regio-Controlled Ring Opening of Thiaisatoic Anhydride by α-Amino Acids.

      • Yann Brouillette, Vincent Lisowski, Jean Martinez

      Pages 9-10

   5. Solid-Phase Synthesis of Phosphinic Dipepetide Isosteres and β Amino Acids via Activated N-Terminal Acrylamides

      • Florian Manzenrieder, Horst Kessler

      Pages 11-12

   6. Parallel Solid-Phase Synthesis of Macrocyclic Peptidomimetics Using Ru-Catalyzed Ring-Closing Metathesis and a New Application of Cross Metathesis

      • Sylvie Beaubien, Hamid R. Hoveyda, Martin Vézina, Éric Marsault, Hugo Tremblay, Laurence Foucher et al.

      Pages 13-14

   7. High Throughput Solid Phase Parallel Synthesis of Macrocyclic Peptidomimetics

      • E. Marsault, H. R. Hoveyda, M. L. Peterson, R. Gagnon, M. Vézina, J.F. Pinault et al.

      Pages 15-16

   8. Development of an Efficient Solid-Phase Synthetic Methodology to Construct a Combinatorial Library of a Potent HDAC Inhibitor

      • Salvatore Di Maro, Jung-Mo Ahn

      Pages 17-18

   9. A Novel Hydrogel Functionalized with Specific Peptidomimetic Ligands for 2-D and 3-D Cell Culture

      • Juntao Luo, Ekama Onofiok, Changying Shi, Ruiwu Liu, Kit S. Lam

      Pages 19-20

   10. Application of the “Libraries from Libraries” Concept to “One-bead One-compound” Combinatorial Chemistry

       • Joseph C. Kappel, Yi C. Fan, Kit S. Lam

       Pages 21-22

   11. An Appreciation of the Scientific Life and Achievements of Bruce Merrifield

       • Alexander R. Mitchell

       Pages 23-25

3. Folding, Recognition, and Catalysis: dedicated to Elkan Blout

   1. The “Bip Method” for Spectroscopic Assignment of the Absolute Configuration of the Spin-Labelled, Cyclic β2,3-Amino Acids β-TOAC and POAC

      • Karen Wright, Laurencev Dutot, Anne Gaucher, Michel Wakselman, Jean-Paul Mazaleyrat, Cristina Peggion et al.

      Pages 29-30

   2. Enzyme Mechanism and Function of a Novel Plant PDI Involved in the Oxidative Folding of Cystine Knot Defense Peptides

      • Christian W. Gruber, Maša Čemažar, Marilyn A. Anderson, David J. Craik

      Pages 31-32

   3. Biosynthesis of Siderophore-Peptides, A Class of Potent Antimicrobial Peptides from Enterobacteria, Requires Two Precursors

      • Gaëlle Vassiliadis, Jean Peduzzi, Delphine Destoumieux-Garzón, Séverine Zirah, Xavier Thomas, Sylvie Rebuffat

      Pages 33-34

   4. Post-Translational Modification and folding of A Lasso-Type Gene-Encoded Antimicrobial Peptide Require Two Enzymes only in Escherichia coli

      • Sophie Duquesne, Delphine Destoumieux-Garzón, Séverine Zirah, Thomas A. Knappe, Christophe Goulard, Jean Peduzzi et al.

      Pages 35-36

   5. Synthesis and 3D-Structure of Conformationally Controlled Nucleo-Peptides

      • Piero Geotti-Bianchini, Marco Crisma, Cristina Peggion, Alberto Bianco, Fernando Formaggio

      Pages 37-38

   6. Mixing Urea and Amide Bonds: Synthesis and Self-Organization of New Hybrid Oligomers

      • Lucile Fischer, Gersande Lena, Jean-Paul Briand, Claude Didierjean, Gilles Guichard

      Pages 39-40

   7. Optimizing the Fold Stability of Miniprotein Sequences

      • D. Victoria Williams, Jasper C. Lin, Brandon L. Kier, Niels H. Andersen

      Pages 41-42

   8. Antimicrobial Peptides Chelating Lanthanide Ions: the Case of Trichogin GA IV Analogues and Terbium(III)

      • Mariano Venanzi, Emanuela Gatto, Lorenzo Stella, Gianfranco Bocchinfuso, Antonio Palleschi, Fernando Formaggio et al.

      Pages 43-44

The American Peptide Society (APS) provides a forum for advancing and promoting knowledge of the chemistry and biology of peptides. The approximately one thousand members of the Society come from North America and from more than thirty other countries throughout the world. Establishment of the APS was a result of the rapid worldwide growth that has occurred in peptide-related research, and of the increasing interaction of peptide scientists with virtually all fields of science. Peptides for Youth: The Proceedings of the the 20th American Peptide Symposium will highlight many of the recent developments in peptide science, with a particular emphasis on how these advances are being applied to basic problems in biology and medicine. The 20th American Peptide Symposium will take place June 26 - 30, 2007 in Montreal, Canada.

• biology
• chemistry
• infectious disease
• membrane proteins
• peptide
• peptidomics
• protein
• proteomics

• Department of Chemistry & Biochemistry, New Mexico State University, Las Cruces, USA

  Susan Del Valle

• Department of Pharmacology, University of Sherbrooke Medical School, Sherbrooke, Canada

  Emanuel Escher

• Département de Chimie, Université de Montréal, Montréal, Canada

  William D. Lubell

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