Neuroimmune Pharmacology

1. Front Matter

   Pages i-l

   PDF

2. Immunology of the Nervous System

   1. Introducing Neuroimmune Pharmacology

      • Howard E. Gendelman, Tsuneya Ikezu

      Pages 1-3

   2. Innate and Adaptive Immunity in Health and Disease

      • Howard E. Gendelman, Eliezer Masliah

      Pages 7-8

   3. Anatomical Networks: Structure and Function of the Nervous System

      • Eliezer Masliah

      Pages 9-20

   4. The Blood Brain Barrier

      • William A. Banks

      Pages 21-38

   5. Anterior Chamber and Retina

      • Leila Kump, Eyal Margalit

      Pages 39-53

   6. Hippocampus and Spatial Memory

      • Huangui Xiong

      Pages 55-64

   7. Glial and Neuronal Cellular Compostion, Biology, and Physiology

      • Kalipada Pahan

      Pages 65-67

   8. Astrocytes, Oligodendrocytes, and Schwann Cells

      • Malabendu Jana, Subhajit Dasgupta, Anuja Ghorpade, Kalipada Pahan

      Pages 69-88

   9. Macrophages, Microglia, and Dendritic C

      • Anuja Ghorpade, Howard E. Gendelman, Jonathan Kipnis

      Pages 89-104

   10. Neuronal and Glial Signaling

       • Murali Prakriya, Richard J. Miller

       Pages 105-121

   11. The Vertebrate Retina

       • Wallace B. Thoreson

       Pages 123-134

   12. Lymphocytes and the Nervous System

       • Larisa Y. Poluektova

       Pages 135-149

   13. Stem Cells

       • Hui Peng, Nicholas Whitney, Kang Tang, Myron Toews, Jialin Zheng

       Pages 151-170

   14. Neurobiology and Neural Systems

       • Tsuneya Ikezu, Howard E. Gendelman

       Pages 171-182

   15. Cytokines and Chemokines

       • Yunlong Huang, Nathan Erdmann, Terry D. Hexum, Jialin Zheng

       Pages 183-205

   16. CNS Cell Signaling

       • Ramendra N. Saha, Keshore R. Bidasee, Kalipada Pahan

       Pages 207-225

3. Nervous System Diseases and Immunity: Clinical Descriptions

   1. Neurodegeneration

      • Serge Przedborski

      Pages 229-237

   2. Multiple Sclerosis and Other Demyelinating Diseases

      • Samantha S. Soldan, Gregory Wu, Clyde Markowitz, Dennis L. Kolson

      Pages 239-255

   3. Guillain-Barré Syndrome, Chronic Inflammatory Demyelinating Polyradiculoneuropathy, and Axonal Degeneration and Regeneration

      • Ralf Gold, Klaus V. Toyka

      Pages 257-262

In the past two decades, enormous strides have been made These tools for exploring brain biochemistry at the cellular in our understanding of the relationships between inflamma- level opened new vistas for understanding brain functioning tion, innate immune responses, adaptive immune responses, and the pathogenesis of human disease. Using these tools, and degenerative human diseases. The developing informa- our laboratory and that of Joseph Rogers in Sun City d- tion has mostly appeared in specialty journals that have dealt onstrated that HLA-DR was strongly expressed on activated only with isolated aspects of these tightly related fields. As microglia. The identification of HLA-DR, a well-known a result, contemporary scientists have had a difficult time leukocyte marker displayed by antigen presenting cells, on finding sources, even in review articles, that provide an these cells vindicated both Hortega and van Furth. The way integrated picture. This volume, by assembling chapters waspaved for many productive investigations exploring the that demonstrate the relationship between these historically properties of microglial cells and their relationship to infl- separated fields, overcomes that difficulty. There are sec- mation and immune responses. This example of a conju- tions on immunology of the nervous system, diseases that tion between a fundamental concept and technical advances result from immunological dysfunction, current therapeutic to establish its validity has been repeated many times since, approaches, and prospects for the future. Overall, it inte- as the chapters in this volume illustrate.

• AIDS
• Chemokine
• Nervous System
• Neuroscience
• Parkinson
• Single Nucleotide Polymorphism
• Translation
• autoimmune disease
• drugs of abuse
• gene therapy
• genes
• infections
• neuroimaging
• physiology

"This book Neuroimmune Pharmacology edited by Drs. Ikezu and Gendelman presents a complete and comprehensive assessment of the basic concepts, current research, and cutting-edge technology regarding the disciplines of neuroscience, immunology, and pharmacology that has been assembled by more than 80 experts. It is an in-depth resource for beginners as well as for experts in the field. The text is clear and concise and includes pertinent concepts related to the pathogenesis of neurodegenerative diseases from a viewpoint of basic immunology and pharmacology."

"The topics are concise, bolstered by datafrom pioneering and current research in the area, and conclude with a summary and a series of review questions. Each section leads into the next section so as to establish afoundation for the subsequent topic area to be addressed. The ordering of the sections is particularly beneficial to students just starting out in the field, allowing them to grasp the fundamental concepts of neuroanatomy, neurobiology, and neuroimmunology before applying that knowledge to specific disease states. Advanced students will also find the textbook helpful in offering a review of previously learned concepts and a multiplicity of chapters that comprehensively cover specific topics to be addressed in the later two sections." (Shilpa J. Buch & Rachel Williams, Journal of Neuroimmune Pharmacology, September, 2008)

• University of Nebraska Medical Center, Omaha, USA

  Howard E. Gendelman, Tsuneya Ikezu

Tsuneya Ikezu, M.D., Ph.D.

Associate Professor, Department of Pharmacology and Experimental Neuroscience

Associate Director, Center for Neurovirology and Neurodegenerative Disorders

Description: Dr. Ikezu was born in Tokyo, Japan, obtained MD-PhD (Clinical Pharmacology in Major) from University of Tokyo School of Medicine, and had post-doctoral training at UCSF (Immunology), Harvard Medical School (Clinical Pharmacology), and Cleveland Clinic Foundation (Neuroscience). He is currently Associate Professor of Pharmacology and Experimental Neuroscience, and Associate Director of Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center

Howard E. Gendelman, M.D.

Larson Professor of Internal Medicine and Infectious Diseases

Chair, Department of Pharmacology and Experimental Neuroscience

Director, Center for Neurovirology and Neurodegenerative Disorders

Dr. Howard Gendelman is the Larson Professor of Medicine and Chair of the Department of Pharmacology and Experimental Neuroscience and Director of the Center for Neurovirology and Neurodegenerative Disorders at the University of Nebraska Medical Center. He received his medical degree from Pennsylvania State University followed by fellowship training and faculty appointments at the Albert Einstein College of Medicine, the Johns Hopkins University Medical Center, the National Institutes of Health, and the Walter Reed Army Institute of Research. He has gained international attention for his work on common mechanisms of nerve damage in Alzheimer’s, Parkinson’s, amyotrophic lateral sclerosis, and HIV-1-associated dementia. His research has lead to groundbreaking discoveries on how inflammation causes nerve cell damage and how drugs and vaccines can be used to reverse it.

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