Overview
- Only literature that is entirely devoted to TRAFs
- Useful not only for researchers who study the biological functions of TRAFs but also for scientists who happen to study a biological system that TRAFs play a significant role
Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 597)
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Table of contents (15 chapters)
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Front Matter
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Back Matter
Keywords
About this book
It has been established that TNF receptor associated factors (TRAFs) are critical signaling mediators for not only the TNF receptor superfamily, but also the interleukin-1 receptor/Toll-like receptor superfamily and the T-cell receptors. They play important roles in mammalian biology including embryonic development, innate and adaptive immune regulation and maintenance of cellular homeostasis. Agents that manipulate the signaling of these receptors are being used or showing promise towards the treatment and prevention of many human diseases such as rheumatoid arthritis, coronary heart disease, transplantation rejection, insulin resistance, multiple organ failure and cancer.
TNF Receptor Associated Factors is the only literature that is entirely devoted to TRAFs. Almost every aspect of TRAF signaling is covered, including the different TRAF family members, their distinct biological functions, the TRAF structures, their modes of receptor recognition, the signaling mechanisms, and the roles of TRAFs in normal cellular functions and in viral infection. TNF Receptor Associated Factors is intended for a wide audience, including researchers in the field of TRAF signaling and students and postdoctoral fellows learning cell biology and cell signal transduction. This exciting new volume is up to date on the most recent advances in TRAF signal transduction.
Editors and Affiliations
Bibliographic Information
Book Title: TNF Receptor Associated Factors (TRAFs)
Editors: Hao Wu
Series Title: Advances in Experimental Medicine and Biology
DOI: https://doi.org/10.1007/978-0-387-70630-6
Publisher: Springer New York, NY
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 2007
Hardcover ISBN: 978-0-387-70629-0Published: 25 June 2007
Softcover ISBN: 978-1-4419-2420-9Published: 19 November 2010
eBook ISBN: 978-0-387-70630-6Published: 15 December 2007
Series ISSN: 0065-2598
Series E-ISSN: 2214-8019
Edition Number: 1
Number of Pages: XIX, 206
Topics: Cell Biology, Developmental Biology, Systems and Data Security