Overview
- Book focuses on the androgen-regulated gene expression program, and examine how recently identified androgen-regulated genes are likely to contribute to the development and progression of prostate cancer
- Recent studies that have attempted to unravel how these genes are deregulated in androgen depletion independent prostate cancer will be included
- Includes supplementary material: sn.pub/extras
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Table of contents (33 chapters)
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Front Matter
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The Role of Androgens in Development of the Normal Prostate and Progression of Prostate Cancer
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Front Matter
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Androgen Metabolism
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Front Matter
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Androgen Receptor Structure/Function Relationships
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Front Matter
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Co-Regulators of the Androgen Receptor
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Front Matter
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Keywords
About this book
Androgens are critical regulators of prostate differentiation and function, as well as prostate cancer growth and survival. Therefore, androgen ablation is the preferred systemic treatment for disseminated prostate cancer. Androgen action is exerted in target tissues via binding the androgen receptor (AR), a nuclear receptor transcription factor.
Historically, the gene expression program mediated by the AR has been poorly understood. However, recent gene expression profiling and more traditional single-gene characterization studies have revealed many androgen-regulated genes that are important mediators of androgen action in both normal and malignant prostate tissue. This book will focus on the androgen-regulated gene expression program, and examine how recently identified androgen-regulated genes are likely to contribute to the development and progression of prostate cancer. Recent studies that have attempted to unravel how these genes are deregulated in androgen depletion independent prostate cancer will be included
Bibliographic Information
Book Title: Androgen Action in Prostate Cancer
Editors: James Mohler, Donald Tindall
DOI: https://doi.org/10.1007/978-0-387-69179-4
Publisher: Springer New York, NY
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer-Verlag New York 2009
Hardcover ISBN: 978-0-387-69177-0
Softcover ISBN: 978-1-4419-2404-9
eBook ISBN: 978-0-387-69179-4
Edition Number: 1
Number of Pages: VIII, 826
Topics: Cancer Research, Human Genetics, Medical Microbiology, Pharmacology/Toxicology, Immunology, Virology