Tumor-Induced Immune Suppression

There is now a pressing need to discuss the already described and newly emerging mechanisms to see how they can be put together in more or less cohesive structure and how they can help to improve immune response to tumors. This monograph will, for the first time, present a comprehensive overview of different mechanisms of immune dysfunction in cancer as well as therapeutic approaches to their correction. It will discuss a number of new mechanisms that have never been discussed in a monograph before: T-cell inhibitory molecules, regulatory tolerogenic DCs, and signaling pathways in antigen-presenting cells involved in T-cell tolerance.

• Antigen
• B7-H1/PD-1
• Dendritic Cells
• Immune Suppressive Mechanisms
• Macrophages
• T Cell
• Tumor Development
• apoptosis
• cancer
• immunobiology
• inhibitory pathway
• molecular mechanisms
• regulation

From the reviews:

"The overall goal of this book is to describe what is currently known about the ways tumors circumvent destruction by the host’s immune system. … The book is targeted at researchers -- immunologists in general and, more specifically, tumor immunologists. It also provides a good source of information for graduate students and postdoctoral fellows. The editors of the book and the authors of the chapters are authorities in the areas they discuss. … a useful addition to the field." (Marion C. Cohen, Doody’s Review Service, August, 2008)

• H. Lee Moffitt Cancer Center, University of South Florida, Tampa, USA

  Dmitry I. Gabrilovich

• Laboratory of Molecular Immunoregulation, National Cancer Institute, Frederick, USA

  Arthur A. Hurwitz

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