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Somatic Cell Nuclear Transfer

  • Book
  • © 2007

Overview

Editors:
  1. Peter Sutovsky

    1. Department of Animal Science, University of Missouri-Columbia, Columbia, USA

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  • Provides timely, refreshing new angle on the cellular and molecular events of somatic cell nuclear transfer (SCNT), one of the most exciting new biotechnologies of the last decade
  • Written by a unique group of top experts in the field, the cellular events arising from SCNT procedure, such as the need for nuclear remodeling, disposal of donor cell organelles, presence of foreign mitochondrial DNA and altered mode of oocyte activation are explained

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Table of contents (9 chapters)

  1. Front Matter

    Pages i-xvi
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  2. Nuclear Remodeling and Nuclear Reprogramming for Making Transgenic Pigs by Nuclear Transfer

    • Randall S. Prather
    Pages 1-13

  3. Somatic Cell Nuclei in Cloning

    • Keith E. Latham, Shaorong Gao, Zhiming Han
    Pages 14-29

  4. Cloning Cattle

    • Björn Oback, David N. Wells
    Pages 30-57

  5. Centrosome Inheritance after Fertilization and Nuclear Transfer in Mammals

    • Qing-Yuan Sun, Heide Schatten
    Pages 58-71

  6. Developmental, Behavioral, and Physiological Phenotype of Cloned Mice

    • Kellie L. K. Tamashiro, Randall R. Sakai, Yukiko Yamazaki, Teruhiko Wakayama, Ryuzo Yanagimachi
    Pages 72-83

  7. Nudeolar Remodeling in Nuclear Transfer Embryos

    • Jozef Laurincik, Poul Maddox-Hyttel
    Pages 84-92

  8. Somatic Cell Nuclear Transfer (SCNT) in Mammals

    • Josef Fulka Jr., Helena Fulka
    Pages 93-102

  9. Mitochondrial DNA Inheritance after SCNT

    • Stefan Hiendleder
    Pages 103-116

  10. Activation of Fertilized and Nuclear Transfer Eggs

    • Christopher Malcuit, Rafael A. Fissore
    Pages 117-131

  11. Back Matter

    Pages 133-135
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Keywords

About this book

When I was first approached to edit the present volume, I was somewhat reluc­ tant to undertake this humbling task because most of my own scientific expertise is derived fi'om studies of mammalian fertilization rather than somatic cell nuclear transfer (SCNT). However, in the last ten years, I was very fortunate to train, col­ laborate, and communicate with a number of distinguished "doners," many of whom kindly agreed to contribute to the present volume. This experience made me appre­ ciate that the understanding of cellular and molecular events during and after SCNT is deeply rooted in our knowledge of fertilization of mammalian ovum by the speramatozoon, to which I prefer to refer to as "natural fertilization," not to say that SCNT should be regarded as "unnatural fertilization". Unique cellular events aris­ ing from SCNT have no parallel in natural fertilization and early pre-implantation development. The list includes the requirement of donor cell-nuclear remodeling, disposal of donor cell organelles, the possibility of heteroplasmy (i. e. , presence of mixed mitochondrial genomes) and altered mode of oocyte activation. Thanks to seminal contributions of my distinguished colleagues, the present volume reviews the progress of SCNT technology in major mammalian species including mouse, pig, and cattle, while at the same time, parallels can be drawn and distinctions made between the cellular and molecular basis of nuclear transfer and fertilization.

Editors and Affiliations

  • Department of Animal Science, University of Missouri-Columbia, Columbia, USA

    Peter Sutovsky

Bibliographic Information

  • Book Title: Somatic Cell Nuclear Transfer

  • Editors: Peter Sutovsky

  • DOI: https://doi.org/10.1007/978-0-387-37754-4

  • Publisher: Springer New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 2007

  • Hardcover ISBN: 978-0-387-37753-7Published: 28 November 2006

  • Softcover ISBN: 978-1-4899-8745-7Published: 25 November 2014

  • eBook ISBN: 978-0-387-37754-4Published: 22 December 2007

  • Edition Number: 1

  • Number of Pages: XVI, 135

  • Topics: Cell Biology, Developmental Biology, Animal Biochemistry

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