Overview
- Authors:
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Jorge Oksenberg
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Department of Neurology, University of California, San Francisco, San Francisco, USA
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David Brassat
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Department of Neurology, University of California, San Francisco, San Francisco, USA
INSERM U563, Toulouse-Purpan, France
- All chapters written by experts in the field
- Summarizes latest advancements in the field
- Essential reading for both immunologists and neuroscientists
- Applications for researchers as well as medical professionals working in the field of immunology
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Table of contents (10 chapters)
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- Silke Schmidt, Lisa F. Barcellos
Pages 13-27
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- Regine Bergholdt, Michael F. McDermott, Flemming Pociot
Pages 28-40
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- Yoshiyuki Ban, Yaron Tomer
Pages 41-58
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- Dorothée Chabas, Isabelle Cournu-Rebeix, Bertrand Fontaine
Pages 59-74
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- Allison Porter, J. Lee Nelson
Pages 75-91
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- Marcela K. Tello-Ruiz, Emily C. Walsh, John D. Rioux
Pages 92-118
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- Renato Mantegazza, Pia Bernasconi
Pages 119-134
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- Mattias Olsson, Sven Hagnerud, David U. R. Hedelius, Per-Arne Oldenborg
Pages 135-143
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- Mehmet L. Guler, Davinna Ligons, Noel R. Rose
Pages 144-154
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Back Matter
Pages 155-158
About this book
utoimmunity is the downstream outcome of a rather extensive and coordinated series of events that include loss of self-tolerance, peripheral lymphocyte Aactivation, disruption of the blood-systems barriers, cellular infiltration into the target organs and local inflammation. Cytokines, adhesion molecules, growth factors, antibodies, and other molecules induce and regulate critical cell functions that perpetuate inflammation, leading to tissue injury and clinical phenotype. The nature and intensity of this response as well as the physiological ability to restore homeostasis are to a large extent conditioned by the unique amino acid sequences that define allelic variants on each of the numerous participating mol ecules. Therefore, the coding genes in their germline configuration play a primary role in determining who is at risk for developing such disorders, how the disease progresses, and how someone responds to therapy. Although genetic components in these diseases are clearly present, the lack of obvious and homogeneous modes of transmission has slowed progress by prevent ing the full exploitation of classical genetic epidemiologic techniques. Furthermore, autoimmune diseases are characterized by modest disease risk heritability and m- tifaceted interactions with environmental influences. Yet, several recent discoveries have dramatically changed our ability to examine genetic variation as it relates to human disease. In addition to the development of large-scale laboratory methods and tools to efficiently recognize and catalog DNA diversity, over the past few years there has been real progress in the application of new analytical and data-manage ment approaches.
