Leptin

1. Front Matter

   Pages i-xv

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2. The Obese (ob/ob) Mouse and the Discovery of Leptin

   • V. Daniel Castracane, Michael C. Henson

   Pages 1-9

3. Leptin Receptors

   • Laura C. Schulz, Eric P. Widmaier

   Pages 11-31

4. Leptin and Obesity

   • Lauren N. Bell, Robert V. Considine

   Pages 33-51

5. Leptin and Neuroendocrinology

   • Abhiram Sahu

   Pages 53-77

6. Leptin-Insulin Interrelationships

   • Asha Thomas-Geevarghese, Robert Ratner

   Pages 79-101

7. Leptin and Other Endocrine Systems

   • Robert V. Considine

   Pages 103-123

8. Leptin and Immune Function, Inflammation and Angiognenesis

   • Giuseppe Matarese, Claudio Procaccini, Veronica De Rosa

   Pages 125-138

9. Leptin and Bone Central control of bone metabolism by leptin

   • Shu Takeda

   Pages 139-147

10. Roles and Regulation of Leptin in Reproduction

    • Michael C. Henson, V.Daniel Castracane

    Pages 149-182

11. Leptin and Cardiovascular Disease

    Pages 183-199

12. Leptin and Cancer

    • Delia-Marina Alexe, Eleni Petridou

    Pages 201-223

13. Lipodystrophy: The experiment of nature to study leptin

    • Rexford S. Ahima, Malaka B. Jackson

    Pages 225-245

14. Pulsatile and Diurnal Leptin Rhythms

    • Luciana Ribeiro, João Vicente Busnello, Julio Licínio

    Pages 247-262

15. Leptin in Farm Animals

    • C. Richard Barb, Gary J. Hausman, Timothy G. Ramsay

    Pages 263-308

16. Genetic Disorders Involving Leptin and the Leptin Receptor

    • I. S. Farooqi

    Pages 309-318

17. Immunoassays for Leptin and Leptin Receptors

    • Jehangir Mistry

    Pages 319-326

18. Clinical Applications of Leptin

    • Elif Ariogly Oral, Alex M. DePaoli

    Pages 327-359

19. Back Matter

    Pages 361-371

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The discovery of leptin by Friedman and his colleagues in 1994 was a seminal discovery in the study of metabolism, providing a new tool to study energy expenditure and appetite regulation. Early studies actively investigated many aspects of metabolism, obesity, and diabetes but it was soon evident that leptin was much more than a metabolic hormone. Today leptin, with almost 11,000 reports in the world's literature, is recognized to be important in many areas of physiology with strong suggestions for involvement in clinical conditions as well. Leptin, of course, remains of great interest in obesity and diabetes but other, previously unimagined, areas are now in the realm of leptin physiology. Perhaps leptin and its involvement in many areas of reproductive physiology may be of greatest interest outside of obesity, but other physiological arenas are becoming increasingly involved in the broader understanding of leptin and its pleiotropic functions. These areas include cardiovascular disease, bone physiology, immune regulation, and even cancer and genetics. Clinical trials have suggested other areas of leptin pharmaceutical potential beyond the original promise of obesity management. These topics and others, for the first time, have been collected in one volume as the first comprehensive review of leptin and its many actions. This area will continue to increase and is now compounded by new endocrine factors that have been elucidated in the wake of leptin's explosion onto the physiological scene.

• bone
• hormone
• leptin receptors
• metabolism
• neuroendocrinology
• obesity
• physiology
• protein
• reproduction

From the reviews:

"This book is unique among reviews on leptin because it covers a number of different areas, and does so well. … Overall, the book serves as an excellent resource for students and researchers and will provide an accessible starting point for more in-depth reading of the primary literature for a given topic." (Matthew J. Brady, Doody’s Electronic Journal, January, 2007)

• Texas Tech University School of Medicine, Lubbock, USA

  V. Daniel Castracane

• Foundation for Blood Research, Scarborough, USA

  V. Daniel Castracane

• Department of Biological Sciences, Purdue University Calumet, Hammond, USA

  Michael C. Henson

• Dept. of Obstetrics and Gynecology, School of Medicine, Tulane University Health Sciences, New Orleans, USA

  Michael C. Henson

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