Overview
- Editors:
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V. Daniel Castracane
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Texas Tech University School of Medicine, Lubbock, USA
Foundation for Blood Research, Scarborough, USA
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Michael C. Henson
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Department of Biological Sciences, Purdue University Calumet, Hammond, USA
Dept. of Obstetrics and Gynecology, School of Medicine, Tulane University Health Sciences, New Orleans, USA
- The timing of this volume is long overdue and it will be the first comprehensive coverage of leptin physiology in the field
- Includes supplementary material: sn.pub/extras
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About this book
The discovery of leptin by Friedman and his colleagues in 1994 was a seminal discovery in the study of metabolism, providing a new tool to study energy expenditure and appetite regulation. Early studies actively investigated many aspects of metabolism, obesity, and diabetes but it was soon evident that leptin was much more than a metabolic hormone. Today leptin, with almost 11,000 reports in the world's literature, is recognized to be important in many areas of physiology with strong suggestions for involvement in clinical conditions as well. Leptin, of course, remains of great interest in obesity and diabetes but other, previously unimagined, areas are now in the realm of leptin physiology. Perhaps leptin and its involvement in many areas of reproductive physiology may be of greatest interest outside of obesity, but other physiological arenas are becoming increasingly involved in the broader understanding of leptin and its pleiotropic functions. These areas include cardiovascular disease, bone physiology, immune regulation, and even cancer and genetics. Clinical trials have suggested other areas of leptin pharmaceutical potential beyond the original promise of obesity management. These topics and others, for the first time, have been collected in one volume as the first comprehensive review of leptin and its many actions. This area will continue to increase and is now compounded by new endocrine factors that have been elucidated in the wake of leptin's explosion onto the physiological scene.
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Article
Open access
14 September 2021
Table of contents (17 chapters)
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- V. Daniel Castracane, Michael C. Henson
Pages 1-9
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- Laura C. Schulz, Eric P. Widmaier
Pages 11-31
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- Lauren N. Bell, Robert V. Considine
Pages 33-51
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- Asha Thomas-Geevarghese, Robert Ratner
Pages 79-101
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- Giuseppe Matarese, Claudio Procaccini, Veronica De Rosa
Pages 125-138
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- Michael C. Henson, V.Daniel Castracane
Pages 149-182
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- Delia-Marina Alexe, Eleni Petridou
Pages 201-223
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- Rexford S. Ahima, Malaka B. Jackson
Pages 225-245
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- Luciana Ribeiro, João Vicente Busnello, Julio LicÃnio
Pages 247-262
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- C. Richard Barb, Gary J. Hausman, Timothy G. Ramsay
Pages 263-308
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- Elif Ariogly Oral, Alex M. DePaoli
Pages 327-359
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Back Matter
Pages 361-371
Reviews
From the reviews:
"This book is unique among reviews on leptin because it covers a number of different areas, and does so well. … Overall, the book serves as an excellent resource for students and researchers and will provide an accessible starting point for more in-depth reading of the primary literature for a given topic." (Matthew J. Brady, Doody’s Electronic Journal, January, 2007)
Editors and Affiliations
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Texas Tech University School of Medicine, Lubbock, USA
V. Daniel Castracane
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Foundation for Blood Research, Scarborough, USA
V. Daniel Castracane
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Department of Biological Sciences, Purdue University Calumet, Hammond, USA
Michael C. Henson
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Dept. of Obstetrics and Gynecology, School of Medicine, Tulane University Health Sciences, New Orleans, USA
Michael C. Henson