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New Concepts of Antiviral Therapy

  • Textbook
  • © 2006

Overview

Editors:
  1. Andreas Holzenburg

    1. Texas A&M University, Microscopy and Imaging Centre, College Station, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Elke Bogner

    1. Institut für Molekulare und Klinische Virologie, Universität Erlangen-Nürnberg, Germany

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • First overview of up-to-date antiviral strategies
  • Review of drug design and development
  • Presents novel Ideas and concepts to develop alternative antiviral drugs
  • Written by leading scientist in the field

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Table of contents (19 chapters)

  1. Front Matter

    Pages i-xviii
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  2. Concepts of therapy for RNA viruses

    1. Front Matter

      Pages 1-1
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    2. Therapeutic vaccination in chronic hepadnavirus infection

      • Michael Roggendorf, Mengji Lu
      Pages 3-20

    3. Characterization of targets for antiviral therapy of Flaviviridae infections

      • Peter Borrowski
      Pages 21-46

    4. Inhibition of Hepatitis C virus by nucleic acid-based antiviral approaches

      • Michael Frese, Ralf Bartenschlager
      Pages 47-86

    5. Inhibitors of respiratory viruses

      • Ernst Kuechler, Joachim Seipelt
      Pages 87-114

    6. Anti-viral approaches against influenza viruses

      • Stephan Pleschka, Stephan Ludwig, Thorsten Wolff, Oliver Planz
      Pages 115-167

    7. A new approach to an Influenza virus live vaccine: Modification of eleavage site of the haemagglu reverse genetics

      • Holger Garn, Hans-Dieter Klenk, Jürgen Stech
      Pages 169-187

    8. New concepts in anti-HIV therapies

      • Justin Stebbing, Mark Bower, Brian Gazzard
      Pages 189-212

    9. Evaluation of current strategies to inhibit HIV entry, integration and maturation

      • Jaqueline D. Reeves, Stephen D. Barr, Stephan Pöhlmann
      Pages 213-254

    10. Managing antiretroviral resistance

      • Barbara Schmidt, Monika Tschoschner, Hauke Walter, Klaus Korn
      Pages 255-279

  3. Concepts of therapy for DNA viruses

    1. Front Matter

      Pages 282-282
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    2. Selective inhibitors of the replication of poxviruses

      • Johan Neyts, Erik de Clercq
      Pages 283-307

    3. Maribavir: A promising new antiherpes therapeutic agent

      • Karen K. Biron
      Pages 309-336

    4. Benzimidazole-D-ribonucleosides as antiviral agents that target HCMV terminase

      • John C. Drach, Leroy B. Townsend, Elke Bogner
      Pages 337-349

    5. Recent developments in anti-herpesviral therapy based on protein kinase inhibitors

      • Thomas Herget, Manfred Marschall
      Pages 351-371

    6. Immune therapy against papillomavirus-related tumors in humans

      • Lutz Gissmann
      Pages 373-394

  4. Concepts of therapy for emerging viruses

    1. Front Matter

      Pages 396-396
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    2. The SARS Coronavirus receptor ACE 2 A potential target for antiviral therapy

      • Jens H. Kuhn, Sheli R. Radoshitzky, Wenhui Li, Swee Kee Wong, Hyeryun Choe, Michael Farzan
      Pages 397-418

    3. Therapy of Ebola and Marburg virus infections

      • Mike Bray
      Pages 419-452
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Keywords

About this book

Antiviral drugs are important tools for treatment or prevention of viral infections. These drugs were first used for monotherapy, but nowadays combinations of antiviral agents are often part of a standard treatment as evidenced by e.g. HAART (highly active antiretroviral therapy). However, in almost every case of antiviral therapy, drug resistant viruses appear. In addition, the low oral bioavailability, toxicity and the number of severe side effects still pose significant problems. All of the latter issues limit the clinical usefulness and drive the need for improved antiviral strategies. These strategies include new drugs and targets, novel modes of action, vector-based treatments and even the block of defined genes by inhibiting mRNA formation (siRNA).

Highlights of this book include the discussion of:

- novel, promising compounds

- concepts of therapy for new/emerging viruses

- managing drug resistance

- new therapeutic strategies

This book presents an overview of the most recent developments. Contributions were carefully selected to ensure quality coverage by acknowledged experts over a wide spectrum and should prove to be of great value to students and serve as a compendium for R and D and educational professionals.

Editors and Affiliations

  • Texas A&M University, Microscopy and Imaging Centre, College Station, USA

    Andreas Holzenburg

  • Institut für Molekulare und Klinische Virologie, Universität Erlangen-Nürnberg, Germany

    Elke Bogner

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