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Misbehaving Proteins

Protein (Mis)Folding, Aggregation, and Stability

  • Book
  • © 2006

Overview

Authors:
  1. Regina M. Murphy

    1. Department of Chemical and Biological Engineering, University of Wisconsin, Madison, USA

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    You can also search for this author in PubMed   Google Scholar

  2. Amos M. Tsai

    1. Human Genome Sciences, Rockville, USA

    View author publications

    You can also search for this author in PubMed   Google Scholar

  • An introductory chapter for readers new to the protein folding field

  • Thorough and clear discussion of computational approaches to understanding and modeling protein aggregation

  • Descriptions of conventional and emerging experimental techniques for analyzing protein misfolding and aggregation

  • Case studies from both academic and industrial researchers, tackling current problems in protein misfolding, aggregation, and stability

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Table of contents (15 chapters)

  1. Front Matter

    Pages I-VIII
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  2. Introduction

    1. Front Matter

      Pages I-VIII
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    2. Protein Folding, Misfolding, Stability, and Aggregation

      • Regina M. Murphy, Amos M. Tsai
      Pages 3-13

  3. Mathematical Models and Computational Methods

    1. Front Matter

      Pages I-VIII
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    2. Nonnative Protein Aggregation

      • Christopher J. Roberts
      Pages 17-46

    3. Simulations of Protein Aggregation

      • Carol K. Hall, Hung D. Nguyen, Alexander J. Marchut, Victoria Wagoner
      Pages 47-77

  4. Experimental Methods

    1. Front Matter

      Pages I-VIII
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    2. Elucidating Structure, Stability, and Conformational Distributions during Protein Aggregation with Hydrogen Exchange and Mass Spectrometry

      • Erik J. Fernandez, Scott A. Tobler
      Pages 81-98

    3. Application of Spectroscopic and Calorimetric Techniques in Protein Formulation Development

      • Angela Wilcox, Rajesh Krishnamurthy
      Pages 99-123

    4. Small-Angle Neutron Scattering as a Probe for Protein Aggregation at Many Length Scales

      • Susan Krueger, Derek Ho, Amos Tsai
      Pages 125-146

    5. Laser Light Scattering as an Indispensable Tool for Probing Protein Aggregation

      • Regina M. Murphy, Christine C. Lee
      Pages 147-165

    6. X-ray Diffraction for Characterizing Structure in Protein Aggregates

      • Hideyo Inouye, Deepak Sharma, Daniel A. Kirschner
      Pages 167-191

    7. Glass Dynamics and the Preservation of Proteins

      • Christopher L. Soles, Amos M. Tsai, Marcus T. Cicerone
      Pages 193-214

  5. Fundamental Studies in Model Systems

    1. Front Matter

      Pages I-VIII
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    2. Folding and Misfolding as a Function of Polypeptide Chain Elongation

      • Silvia Cavagnero, Nese Kurt
      Pages 217-245

    3. Determinants of Protein Folding and Aggregation in P22 Tailspike Protein

      • Matthew J. Gage, Brian G. Lefebvre, Anne S. Robinson
      Pages 247-264

    4. Factors Affecting the Fibrillation of α-Synuclein, a Natively Unfolded Protein

      • Anthony L. Fink
      Pages 265-285

    5. Molten Globule-Lipid Bilayer Interactions and Their Implications for Protein Transport and Aggregation

      • Lisa A. Kueltzo, C. Russell Middaugh
      Pages 287-309

  6. Protein Product Development

    1. Front Matter

      Pages I-VIII
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    2. Self-Association of Therapeutic Proteins

      • Mary E. M. Cromwell, Chantal Felten, Heather Flores, Jun Liu, Steven J. Shire
      Pages 313-330
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Keywords

About this book

Misfoldedaggregatedproteinoncewasconsideredasinterestingasyesterday’strash—a bothersome by-product of important and productive activities, to be disposed of and forgotten as quickly as possible. Yesterday’s trash has become today’s focus of cons- erable scienti?c interest for at least two reasons: (1) protein aggregates are at the core of a number of chronic degenerative diseases such as Alzheimer’s disease, and (2) - gregation poses signi?cant obstacles to the manufacture of safe, ef?cacious, and stable protein products. As interest in protein misfolding, aggregation, and stability has soared beyond the core group of traditional protein-folding scientists, and as substantial scienti?c progress in understanding and controlling protein misfolding has been achieved, the need to summarize the state of the art became manifest. Although there are many excellent texts and edited collections on protein structure and folding, these volumes tend to relegate protein misfolding and aggregation to a minor role. Review articles and books focused on the biological role of protein aggregates in diseases have been published recently. Misbehaving Proteins: Protein (Mis)folding, Aggregation, and Stability differs from theseotherrecenteffortsinitsemphasisonfundamentalcomputationalandexperimental studies and in its linkage of disparate consequences of protein misfolding (e.g., from clinical manifestations to manufacturing headaches) to their common causes.

Authors and Affiliations

  • Department of Chemical and Biological Engineering, University of Wisconsin, Madison, USA

    Regina M. Murphy

  • Human Genome Sciences, Rockville, USA

    Amos M. Tsai

Bibliographic Information

  • Book Title: Misbehaving Proteins

  • Book Subtitle: Protein (Mis)Folding, Aggregation, and Stability

  • Authors: Regina M. Murphy, Amos M. Tsai

  • DOI: https://doi.org/10.1007/978-0-387-36063-8

  • Publisher: Springer New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer-Verlag New York 2006

  • Hardcover ISBN: 978-0-387-30508-0Published: 24 May 2006

  • Softcover ISBN: 978-1-4419-2142-0Published: 29 November 2010

  • eBook ISBN: 978-0-387-36063-8Published: 12 October 2007

  • Edition Number: 1

  • Number of Pages: VIII, 354

  • Number of Illustrations: 120 b/w illustrations, 17 illustrations in colour

  • Topics: Proteomics, Biochemistry, general, Biochemical Engineering, Biotechnology, Analytical Chemistry

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